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Author Details

Catherine C Smith
University of California San Francisco
2009
51
23
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37292835Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification.bioRxiv2023
37895201Complex Genomic Rearrangements Involving <i>ETV6</i>::<i>ABL1</i> Gene Fusion in an Individual with Myeloid Neoplasm.Genes (Basel)2023
37992684Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML.Cell Rep Med2023
37572683Standardising acute myeloid leukaemia classification systems: a perspective from a panel of international experts.Lancet Haematol2023
37678052Association of geriatric measures and global frailty with cognitive decline after allogeneic hematopoietic cell transplantation in older adults.J Geriatr Oncol2023
37815132The FLT3<sup>N701K</sup> mutation causes clinical AML resistance to gilteritinib and triggers TKI sensitivity switch to quizartinib.Am J Hematol2023
35247612Patterns and Predictors of Functional Decline after Allogeneic Hematopoietic Cell Transplantation in Older Adults.Transplant Cell Ther2022
35637252Clinical outcomes in patients with relapsed/refractory FLT3-mutated acute myeloid leukemia treated with gilteritinib who received prior midostaurin or sorafenib.Blood Cancer J2022
35395091The Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms.Mol Cancer Ther2022
35849791Venetoclax Plus Gilteritinib for <i>FLT3</i>-Mutated Relapsed/Refractory Acute Myeloid Leukemia.J Clin Oncol2022
35130342Molecular profile of FLT3-mutated relapsed/refractory patients with AML in the phase 3 ADMIRAL study of gilteritinib.Blood Adv2022
33059507Therapy for acute myelogenous leukemia revisited: moving away from a one-size-fits-all approach.Expert Rev Anticancer Ther2021
33626861The <i>EBF1-PDGFRB</i> T681I mutation is highly resistant to imatinib and dasatinib <i>in vitro</i> and detectable in clinical samples prior to treatment.Haematologica2021
33707421Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia.Nat Commun2021
33666651Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib.Blood Adv2021
34103301Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.Clin Cancer Res2021
34297319Correction to: Pharmacokinetic Profile of Gilteritinib: A Novel FLT-3 Tyrosine Kinase Inhibitor.Clin Pharmacokinet2021
31493541Functional Status as Measured by Geriatric Assessment Predicts Inferior Survival in Older Allogeneic Hematopoietic Cell Transplantation Recipients.Biol Blood Marrow Transplant2020
32040554Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations.Blood Adv2020
33425766<i>FLT3</i> Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies.Front Oncol2020
32862867FLT3 Inhibition in Acute Myeloid Leukemia.Clin Lymphoma Myeloma Leuk2020
32304015Pharmacokinetic Profile of Gilteritinib: A Novel FLT-3 Tyrosine Kinase Inhibitor.Clin Pharmacokinet2020
32330242A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia.Blood Adv2020
31088841Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia.Cancer Discov2019
31808872The growing landscape of FLT3 inhibition in AML.Hematology Am Soc Hematol Educ Program2019
30733203Roman warfare: targeting of support cells in AML.Blood2019
29859851Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial.Lancet Oncol2018
28490572Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis.Blood2017
27158668The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia.JCI Insight2016
26490487Long-term outcomes of patients with intermediate-risk acute myeloid leukemia treated with autologous hematopoietic cell transplant in first complete remission.Leuk Lymphoma2016
26511402Novel TKI-resistant BCR-ABL1 gatekeeper residue mutations retain in vitro sensitivity to axitinib.Leukemia2016
26585411Quizartinib elicits differential responses that correlate with karyotype and genotype of the leukemic clone.Leukemia2016
25243620Delayed hematopoietic recovery after auto-SCT in patients receiving arsenic trioxide-based therapy for acute promyelocytic leukemia: a multi-center analysis.Bone Marrow Transplant2015
26108694FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors.Leukemia2015
25847190Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.Cancer Discov2015
25765758Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.Eur J Med Chem2015
25776193A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia.Clin Lymphoma Myeloma Leuk2015
24374145Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor.Leuk Res2014
25456130Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.Cell Rep2014
25531068Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy.Elife2014
24894413Hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of adverse events and overall survival in older allogeneic transplant recipients.J Geriatr Oncol2014
24623852Crenolanib is a selective type I pan-FLT3 inhibitor.Proc Natl Acad Sci U S A2014
24682858FLT3 inhibitors in AML: are we there yet?Curr Hematol Malig Rep2014
23430109Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.Blood2013
24324154Disease diversity and FLT3 mutations.Proc Natl Acad Sci U S A2013
23714533The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia.Am Soc Clin Oncol Educ Book2013
22504184Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.Nature2012
24451819Mechanisms of resistance to targeted therapies in acute myeloid leukemia and chronic myeloid leukemia.Am Soc Clin Oncol Educ Book2012
21948230Is it downhill from here? Eliminating leukemic stem cells and curing chronic myeloid leukemia.Clin Cancer Res2011
22160023Tyrosine kinase inhibitor therapy for chronic myeloid leukemia: approach to patients with treatment-naive or refractory chronic-phase disease.Hematology Am Soc Hematol Educ Program2011
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Collaborators

University of California San Francisco
Co-authored papers 22
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Co-authored papers 10
University of California san francisco
Co-authored papers 7
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Co-authored papers 7
University of California san francisco
Co-authored papers 4
University of California San Francisco
Co-authored papers 3
Genentech Inc.
Co-authored papers 3
Schools of Pharmacy and Medicine, University of California san francisco
Co-authored papers 3
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
12224University of California san francisco
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
University of California berkeley
Co-authored papers 2
Georgia Cancer Center
Co-authored papers 2
University of California San Francisco
Co-authored papers 1
Oregon Health & Science University
Co-authored papers 1
Benioff Children's Hospitals, University of California san francisco
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Instituto de Salud Carlos III
Co-authored papers 1
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
University of California los angeles
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
University of Colorado Division of Hematology
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
is executive director of clinical development at TerSera Therapeutics
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St Jude Children's Research Hospital
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Massachusetts General Hospital
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University of California san francisco
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Google Accelerated Science Team, Google Inc
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Icahn School of Medicine at Mount Sinai
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