Author details

Full Name

David R Liu

Affiliation

ORCID

Career Start Year

1995

Papers

257

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37322276	Adenine transversion editors enable precise, efficient Aâ¿¢T-to-Câ¿¢G base editing in mammalian cells and embryos.	Nat Biotechnol	2024
37142705	Efficient prime editing in mouse brain, liver and heart with dual AAVs.	Nat Biotechnol	2024
37169967	A prime editor mouse to model a broad spectrum of somatic mutations in vivo.		2023
36357719	Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity.	Nature Biotechnology	2023
36344749	Prime editing for precise and highly versatile genome manipulation.	Nature Reviews Genetics	2023
36076084	High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs.	Nat Biotechnol	2023
37853259	Author Correction: Efficient Câ¿¢G-to-Gâ¿¢C base editors developed using CRISPRi screens, target-library analysis, and machine learning.		2023
37657419	Phage-assisted evolution and protein engineering yield compact, efficient prime editors.		2023
37582836	Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo.	Nat Commun	2023
37561581	Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy.		2023
37783940	Assigning functionality to cysteines by base editing of cancer dependency genes.	Nat Chem Biol	2023
37547293	Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells.	Mol Ther Nucleic Acids	2023
37400614	Potent and uniform fetal hemoglobin induction via base editing.	Nat Genet	2023
36824928	Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells .		2023
37328653	Small-molecule discovery through DNA-encoded libraries.		2023
37137305	Massively parallel base editing to map variant effects in human hematopoiesis.	Cell	2023
37069266	Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice.		2023
36945568	A molecular glue approach to control the half-life of CRISPR-based technologies.	bioRxiv	2023
36944331	Human TÂ cell generation is restored in CD3Î´ severe combined immunodeficiency through adenine base editing.		2023
37312453	Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.	Mol Ther	2023
36996170	Base editing rescue of spinal muscular atrophy in cells and in mice.		2023
36865281	Multiplex Base Editing to Protect from CD33-Directed Therapy: Implications for Immune and Gene Therapy.		2023
36800642	InÂ vivo HSC prime editing rescues sickle cell disease in a mouse model.		2023
36797483	Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice.	Nat Med	2023
36993169	Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing <i>in vivo</i>.	bioRxiv	2023
34880468	Author Correction: Engineered pegRNAs improve prime editing efficiency.	Nature Biotechnology	2022
35902773	Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors.	Nat Biomed Eng	2022
35513721	Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells.	Nat Genet	2022
36163383	Discovery and molecular basis of subtype-selective cyclophilin inhibitors.	Nat Chem Biol	2022
35383196	In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration.	Nat Commun	2022
35946940	Efficient and Scalable Process to Produce Novel and Highly Bioactive Purified Cytosolic Crystals from Bacillus thuringiensis.	Microbiology spectrum	2022
35379961	CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA.	Nat Biotechnol	2022
36006707	In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies.	JCI insight	2022
35941224	Designing and executing prime editing experiments in mammalian cells.		2022
35931809	Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors.	Nat Biomed Eng	2022
35798006	Therapeutic inÂ vivo delivery of gene editing agents.	Cell	2022
35927274	Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning.	Nature Communications	2022
36122230	Precision genome editing in the eye.	Proceedings of the National Academy of Sciences of the United States of America	2022
36418298	Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.	Nature Communications	2022
36385635	ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation.	Scientific Reports	2022
34737067	Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human TÂ cells and hematopoietic stem and progenitor cells using base editing.	Molecular Therapy	2022
34608327	Engineered pegRNAs improve prime editing efficiency.	Nature Biotechnology	2022
35021064	Engineered virus-like particles for efficient inÂ vivo delivery of therapeutic proteins.	Cell	2022
34887556	Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing.	Nature Biotechnology	2022
34635842	Reconstruction of evolving gene variants and fitness from short sequencing reads.	Nature Chemical Biology	2021
34079130	Base editing of haematopoietic stem cells rescues sickle cell disease in mice.	Nature	2021
33589617	PrimeDesign software for rapid and simplified design of prime editing guide RNAs.	Nature Communications	2021
34285403	Base editor treats progeria in mice.	Nature	2021
33462442	Precision genome editing using cytosine and adenine base editors in mammalian cells.		2021
33828315	The NIH Somatic Cell Genome Editing program.	Nature	2021