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Author Details

Christopher B Newgard
Duke Molecular Physiology Institute
1981
397
110
PMIDPaper TitleJournal TitlePublished Year
38066593Sex Differences in Branched-chain Amino Acid and Tryptophan Metabolism and Pathogenesis of Youth-onset Type 2 Diabetes.J Clin Endocrinol Metab2024
37962326Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions.Obesity (Silver Spring)2024
36778330Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.bioRxiv2023
37552540Mitochondrial metabolites predict adverse cardiovascular events in individuals with diabetes.JCI Insight2023
37645712<i>Prevotella copri</i>-related effects of a therapeutic food for malnutrition.bioRxiv2023
37267108Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.Cell Rep2023
37163372Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.Cell Rep2023
36517247Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population.Clin J Am Soc Nephrol2023
36914626De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics.Nat Commun2023
34608929Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes.J Clin Endocrinol Metab2022
35739205Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.Sci Rep2022
35838316Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues.Diabetes2022
35797133Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.JCI Insight2022
35603596Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF.Circulation2022
35749484Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.PLoS One2022
36304102KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands.iScience2022
35988648Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice.J Biol Chem2022
35921984Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.Mol Metab2022
34980540Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.Clin Breast Cancer2022
33321098Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.Cell Metab2021
33627633Metabolites and diabetes remission after weight loss.Nutr Diabetes2021
33624438The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.Obesity (Silver Spring)2021
33596993Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial.Trials2021
33765118BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis.Endocrinology2021
33762012Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes.Cancer Metab2021
33586679Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis.J Clin Invest2021
33723250Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.Nat Commun2021
34903884NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.Nat Metab2021
34277361Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study.Ann Glob Health2021
34044180Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.Mol Metab2021
34043632Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.PLoS One2021
34344360Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.Cardiovasc Diabetol2021
34194621Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study.Oncotarget2021
34001614Gut microbiome contributions to altered metabolism in a pig model of undernutrition.Proc Natl Acad Sci U S A2021
34255031Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism.J Clin Endocrinol Metab2021
33398164Mechanisms controlling pancreatic islet cell function in insulin secretion.Nat Rev Mol Cell Biol2021
32176701Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.PLoS One2020
31794262Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats.Am J Physiol Endocrinol Metab2020
33176135Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.Cell Rep2020
32865009β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.Am J Physiol Endocrinol Metab2020
30590691Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.Nucleic Acids Res2019
31498869Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.J Clin Endocrinol Metab2019
31296738Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.Science2019
31555072Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys.Front Neurosci2019
31238265Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity.Environ Int2019
30710149Improving human β-cell maturation in vitro.Nat Cell Biol2019
30889527Peripheral blood metabolite profiles associated with new onset atrial fibrillation.Am Heart J2019
30733403Branched-chain amino acids in disease.Science2019
30824582Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers.Mol Cancer Ther2019
31000437Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.Mol Cell2019
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Collaborators

James R Bain
Duke University Medical Center
Co-authored papers 81
Robert D Stevens
Duke Molecular Physiology Institute
Co-authored papers 78
Michael J Muehlbauer
Duke University School of Medicine
Co-authored papers 75
Svati H Shah
Duke Molecular Physiology Institute
Co-authored papers 35
William E Kraus
Duke Molecular Physiology Institute, Duke University School of Medicine
Co-authored papers 22
Deborah M Muoio
Co-authored papers 20
Jonathan C Schisler
Co-authored papers 15
Alexander D Sherry
University of Texas MD Anderson Cancer Center
Co-authored papers 11
William L Lowe
Feinberg School of Medicine, Northwestern University
Co-authored papers 11
Carol Haynes
Duke Molecular Physiology Institute Durham NC.
Co-authored papers 11
Elizabeth R Hauser
Duke University School of Medicine
Co-authored papers 9
Robert V Farese
Harvard T.H. Chan School of Public Health
Co-authored papers 8
Lydia Coulter Kwee
Co-authored papers 8
Hal K Berman
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 7
Bert W O'Malley
Center for Coregulator Research, Baylor College of Medicine
Co-authored papers 7
Robert J Fletterick
University of California San Francisco
Co-authored papers 7
Eric Verdin
Buck Institute for Research on Aging
Co-authored papers 7
Matthew D Hirschey
Duke Molecular Physiology Institute, Duke University School of Medicine
Co-authored papers 6
Patrick J Casey
Co-authored papers 5
Eric S Goetzman
Co-authored papers 4
Donna K Arnett
Co-authored papers 4
Andrea L Hevener
Co-authored papers 4
Matthew J Watt
Co-authored papers 4
Bradford W Gibson
The Buck Institute for Research on Aging
Co-authored papers 4
Timothy P Rolph
Co-authored papers 4
Mukesh K Jain
Co-authored papers 4
Jeff K Trimmer
Co-authored papers 3
Mary Julia Brosnan
Co-authored papers 3
Geoffrey S Ginsburg
National Institutes of Health
Co-authored papers 3
Susan G Hilsenbeck
Co-authored papers 3
Release 1.2