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Author Details

Robert J Nichols
Stanford University
2004
52
29
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37141099Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity.Cell Rep2023
34992038Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.Eur J Med Chem2022
35478845Editorial: LRRK2-Fifteen Years From Cloning to the Clinic.Front Neurosci2022
35707141Discovery of 1<i>H-</i>Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors.ACS Med Chem Lett2022
35730403Targeting <i>LRRK2</i> mutations in Parkinson's disease.Future Med Chem2022
35599495Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.J Parkinsons Dis2022
36388213Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk.Front Neurol2022
36049274Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors.Eur J Med Chem2022
35016853The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.Brain Res2022
35266954The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.J Cell Biol2022
35326469A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.Cells2022
34144124Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation.Neurobiol Dis2021
33494262Genetic and Environmental Factors Influence the Pleomorphy of <i>LRRK2</i> Parkinsonism.Int J Mol Sci2021
34815415The encapsulin from Thermotoga maritima is a flavoprotein with a symmetry matched ferritin-like cargo protein.Sci Rep2021
34751132A nanocompartment system contributes to defense against oxidative stress in <i>Mycobacterium tuberculosis</i>.Elife2021
30597610LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.Mov Disord2019
30796162Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.J Biol Chem2019
29514186CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition.Endocrinology2018
29519959P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.Biochem J2018
27911006LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies.Mov Disord2017
28353278LRRK2 Phosphorylation.Adv Neurobiol2017
28635326Encapsulins: molecular biology of the shell.Crit Rev Biochem Mol Biol2017
27023778Erratum: Multisystem Lewy body disease and the other parkinsonian disorders.Nat Genet2016
26608811Programmed Ribosomal Frameshifting Mediates Expression of the α-Carboxysome.J Mol Biol2016
27402158Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.Nucleic Acids Res2016
27486247The stringent response regulates adaptation to darkness in the cyanobacterium Synechococcus elongatus.Proc Natl Acad Sci U S A2016
25609650Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.Mol Syst Biol2015
26620112Multisystem Lewy body disease and the other parkinsonian disorders.Nat Genet2015
25939886LRRK2 dephosphorylation increases its ubiquitination.Biochem J2015
24345765Adult tissue sources for new β cells.Transl Res2014
25009464LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status.Front Mol Neurosci2014
24591621Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain.Proc Natl Acad Sci U S A2014
23937259Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.Biochem J2013
22004453Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition.J Neurochem2012
22988882Pharmacological inhibition of LRRK2 cellular phosphorylation sites provides insight into LRRK2 biology.Biochem Soc Trans2012
22952710Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation.PLoS One2012
23088750Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.J Am Chem Soc2012
21185072Phenotypic landscape of a bacterial cell.Cell2011
22153074Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo.Cell2011
19696012Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.Biol Reprod2010
21183073Regulation of peptidoglycan synthesis by outer-membrane proteins.Cell2010
20659021Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.Biochem J2010
2064245314-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.Biochem J2010
19740074Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.Biochem J2009
18186022A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples.Proteomics2008
19077320Functional characterization of the vaccinia virus I5 protein.Virol J2008
19160513High-throughput, quantitative analyses of genetic interactions in E. coli.Nat Methods2008
18701587The vaccinia virus gene I2L encodes a membrane protein with an essential role in virion entry.J Virol2008
17464504High-throughput killer cell immunoglobulin-like receptor genotyping by MALDI-TOF mass spectrometry with discovery of novel alleles.Immunogenetics2007
17447891LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.Biochem J2007
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Collaborators

Thomas J Montine
Stanford University
Co-authored papers 7
Carol A Gross
University of California san francisco
Co-authored papers 5
David F Savage
University of California berkeley
Co-authored papers 5
Athanasios Typas
University of California san francisco
Co-authored papers 4
Dario R Alessi
University of Dundee
Co-authored papers 4
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 3
Khanh Nguyen
Department of Pharmaceutical Technology and Biopharmacy, University of Groningen
Co-authored papers 3
Rachna Chaba
Indian Institute of Science Education and Research (IISER) Mohali
Co-authored papers 2
Michael Shales
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 2
Jonathan S Weissman
Whitehead Institute for Biomedical Research
Co-authored papers 2
Mu Wang
Academy of Pharmacy, Xi'an Jiaotong-Liverpool University
Co-authored papers 2
Matylda Zietek
Co-authored papers 2
Sean R Collins
University of California davis
Co-authored papers 1
William T Dauer
Peter O'Donnell Jr. Brain Institute
Co-authored papers 1
Scott A Oakes
Pritzker School of Medicine, University of Chicago
Co-authored papers 1
Christopher S Waters
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Richard K Niles
Co-authored papers 1
Barry L Wanner
Harvard Medical School
Co-authored papers 1
Timothy C Cox
University of Missouri-Kansas City Kansas City
Co-authored papers 1
Danica Galoni?? Fujimori
University of California San Francisco
Co-authored papers 1
Peer Bork
University of Wurzburg
Co-authored papers 1
Christian Mirescu
Merck & Co. Inc.
Co-authored papers 1
Lewis C Cantley
Co-authored papers 1
Christina M Homer
University of California san francisco
Co-authored papers 1
Katie A Lien
Pritzker School of Medicine, University of Chicago
Co-authored papers 1
Torsten Wittmann
University of California san francisco
Co-authored papers 1
Deborah A Siegele
Texas A&M University, College Station
Co-authored papers 1
Vera van Noort
Leiden University, Institute of Biology Leiden
Co-authored papers 1
Molly FitzGibbon
University of California San Diego
Co-authored papers 1
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 1
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