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Author Details

Christian A Hassig
Sanford Burnham Prebys Medical Discovery Institute
1994
31
19
PMIDPaper TitleJournal TitlePublished Year
33414172Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.Cancer Res2021
31470128Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC.J Thorac Oncol2019
27031987Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML).PLoS One2016
26265713Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.J Biomol Screen2015
26603897SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.Cancer Res2015
24500713Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.J Biol Chem2014
24870016Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.J Biomol Screen2014
23589174Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2.Clin Cancer Res2013
22182498Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.Bioorg Med Chem Lett2012
21036913Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.J Pharmacol Exp Ther2011
21986586Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.Bioorg Med Chem Lett2011
20931971Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.J Med Chem2010
19364813KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.Mol Pharmacol2009
19374401Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.J Med Chem2009
18483295KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.Mol Cancer Ther2008
20161838Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response.Curr Chem Genomics2008
18954984Alpha-mercaptoketone based histone deacetylase inhibitors.Bioorg Med Chem Lett2008
18954983Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor.Bioorg Med Chem Lett2008
18566220KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling.Mol Cancer Ther2008
14698179Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.Bioorg Med Chem Lett2004
12672694XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.Genes Dev2003
10220385Three proteins define a class of human histone deacetylases related to yeast Hda1p.Proc Natl Acad Sci U S A1999
9804427Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.Nature1998
9520398A role for histone deacetylase activity in HDAC1-mediated transcriptional repression.Proc Natl Acad Sci U S A1998
9520369Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase.Proc Natl Acad Sci U S A1998
9667866Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.Curr Opin Chem Biol1997
9150137Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase.Cell1997
9150133Histone deacetylase activity is required for full transcriptional repression by mSin3A.Cell1997
9384528Fiber-derived butyrate and the prevention of colon cancer.Chem Biol1997
8602529A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.Science1996
8071992Structural analysis of antibody specificity. Detailed comparison of five Fab'-steroid complexes.J Mol Biol1994
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Collaborators

Broad Institute
Co-authored papers 9
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Co-authored papers 3
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Co-authored papers 3
Moffitt Cancer Center
Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 2
Oregon Health & Science University
Co-authored papers 1
Sungkyunkwan University
Co-authored papers 1
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Yale School of Medicine
Co-authored papers 1
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Oregon Health and Science University
Co-authored papers 1
Oregon Health and Science University
Co-authored papers 1
Sanford-Burnham Medical Research Institute
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Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
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University of California san francisco
Co-authored papers 1
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Co-authored papers 1
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Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
McGill University
Co-authored papers 1
Knight Cancer Institute, Oregon Health and Science University
Co-authored papers 1
University of Southern California
Co-authored papers 1
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Beth Israel Deaconess Medical Center and Harvard Medical School
Co-authored papers 1