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Author Details

Rachelle S Doody
F. Hoffmann-La Roche Ltd
1981
206
60
PMIDPaper TitleJournal TitlePublished Year
36454709Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).Alzheimers Dement2023
37966285Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.N Engl J Med2023
38055260Tominersen in Adults with Manifest Huntington's Disease.N Engl J Med2023
37461624Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies <i>LRRC4C, LHX5-AS1</i> and nominates ancestry-specific loci <i>PTPRK</i> , <i>GRB14</i> , and <i>KIAA0825</i> as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.medRxiv2023
36641605Establishing Clinically Meaningful Change on Outcome Assessments Frequently Used in Trials of Mild Cognitive Impairment Due to Alzheimer's Disease.J Prev Alzheimers Dis2023
34776434Connecting Cohorts to Diminish Alzheimer's Disease (CONCORD-AD): A Report of an International Research Collaboration Network.J Alzheimers Dis2022
35542994Therapeutic Targets for Alzheimer's Disease: Amyloid Vs. Non-Amyloid. Where Does Consensus Lie Today? An CTAD Task Force Report.J Prev Alzheimers Dis2022
36447240Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer's disease.Alzheimers Res Ther2022
35921451Trial of Prasinezumab in Early-Stage Parkinson's Disease.N Engl J Med2022
36121669Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials.JAMA Neurol2022
33336218Thirty-Six-Month Amyloid Positron Emission Tomography Results Show Continued Reduction in Amyloid Burden with Subcutaneous Gantenerumab.J Prev Alzheimers Dis2021
33569564Chinese Version of the Baylor Profound Mental Status Examination: A Brief Staging Measure for Patients with Severe Alzheimer's Disease.J Prev Alzheimers Dis2021
33569561Psychometric Properties of the Clinical Dementia Rating - Sum of Boxes and Other Cognitive and Functional Outcomes in a Prodromal Alzheimer's Disease Population.J Prev Alzheimers Dis2021
33579838Different Cognitive Profiles Are Associated with Progression Rate and Age at Death in Probable Alzheimer's Disease.J Alzheimers Dis2021
34585210Editorial: Consequences of the FDA Decision on Aducanumab for Patient Care and Research.J Prev Alzheimers Dis2021
34155411A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.Nat Med2021
34101788Platform Trials to Expedite Drug Development in Alzheimer's Disease: A Report from the EU/US CTAD Task Force.J Prev Alzheimers Dis2021
32277473What works and what does not work in Alzheimer's disease? From interventions on risk factors to anti-amyloid trials.J Neurochem2020
32010919Viewpoint: The Role of Futility Analyses in Alzheimer's Disease Clinical Trials.J Prev Alzheimers Dis2020
32573256Longitudinal Sensitivity of Alzheimer's Disease Severity Staging.Am J Alzheimers Dis Other Demen2020
31831056Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis.Alzheimers Res Ther2019
29741663Statistical Model of Dynamic Markers of the Alzheimer's Pathological Cascade.J Gerontol B Psychol Sci Soc Sci2018
29972209What Have We Learned from Expedition III and EPOCH Trials? Perspective of the CTAD Task Force.J Prev Alzheimers Dis2018
28714976Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.Nat Genet2017
28436391Prediction of Conversion to Alzheimer's Disease with Longitudinal Measures and Time-To-Event Data.J Alzheimers Dis2017
28157100Efficacy and Safety of Donepezil in Chinese Patients with Severe Alzheimer's Disease: A Randomized Controlled Trial.J Alzheimers Dis2017
28243501Validation of olfactory deficit as a biomarker of Alzheimer disease.Neurol Clin Pract2017
29186281EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials.J Prev Alzheimers Dis2017
29181492Developing Disease-Modifying Treatments in Alzheimer's Disease - A Perspective from Roche and Genentech.J Prev Alzheimers Dis2017
28550255Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD).J Alzheimers Dis2017
22421539Binomial regression with a misclassified covariate and outcome.Stat Methods Med Res2016
28459045Re-Engineering Alzheimer Clinical Trials: Global Alzheimer's Platform Network.J Prev Alzheimers Dis2016
29210442Registries and Cohorts to Accelerate Early Phase Alzheimer's Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer's Disease Task Force.J Prev Alzheimers Dis2016
26471212An open-label study to assess safety, tolerability, and effectiveness of dextromethorphan/quinidine for pseudobulbar affect in dementia: PRISM II results.CNS Spectr2016
26444781Validation of the Spanish version of the Baylor Profound Mental Status Examination.J Alzheimers Dis2016
27590297Erratum to: PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury.BMC Neurol2016
27172829Predicting disease progression in progressive supranuclear palsy in multicenter clinical trials.Parkinsonism Relat Disord2016
27571265Cognitively-Related Basic Activities of Daily Living Impairment Greatly Increases the Risk of Death in Alzheimers Disease.PLoS One2016
27276999PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury.BMC Neurol2016
26757777Prevalence and correlates of cognitive asymmetry in a large sample of Alzheimer's disease patients.J Clin Exp Neuropsychol2016
26782946A hidden Markov model approach to analyze longitudinal ternary outcomes when some observed states are possibly misclassified.Stat Med2016
26079412Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase.Alzheimers Dement2016
25938338Adding delayed recall to the ADAS-cog improves measurement precision in mild Alzheimer's disease: Implications for predicting instrumental activities of daily living.Psychol Assess2015
29854931Delayed-start analysis: Mild Alzheimer's disease patients in solanezumab trials, 3.5 years.Alzheimers Dement (N Y)2015
28572692Joint coverage probability in a simulation study on Continuous-Time Markov Chain parameter estimation.J Appl Stat2015
26247004Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force.J Prev Alzheimers Dis2015
26617181How Do Scores on the ADAS-Cog, MMSE, and CDR-SOB Correspond?Clin Neuropsychol2015
27239525Lipoprotein-associated phospholipase A2, homocysteine, and Alzheimer's disease.Alzheimers Dement (Amst)2015
26120368Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials.Alzheimers Res Ther2015
26120369Alzheimer's disease progression by geographical region in a clinical trial setting.Alzheimers Res Ther2015
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Collaborators

Alzheimer's Therapeutic Research Institute, University of Southern California
Co-authored papers 22
Keck School of Medicine (EJ, University of Southern California
Co-authored papers 17
Stark Neurosciences Research Institute, Indiana University School of Medicine (IUSM)
Co-authored papers 16
Butler Hospital, and Warren Alpert Medical School of Brown University
Co-authored papers 14
Washington University School of Medicine
Co-authored papers 13
Mayo Clinic Rochester
Co-authored papers 13
University of California
Co-authored papers 12
Oregon Center for Aging & Technology
Co-authored papers 11
Brigham and Women's Hospital, Massachusetts General Hospital
Co-authored papers 11
West Virginia University
Co-authored papers 8
Co-authored papers 8
University of California San Francisco
Co-authored papers 7
Yale University School of Medicine
Co-authored papers 7
University of California San Diego
Co-authored papers 7
Barrow Neurological Institute
Co-authored papers 7
University of California
Co-authored papers 6
UK Dementia Research Institute, University College London
Co-authored papers 6
University of Pennsylvania
Co-authored papers 6
Mayo Clinic Rochester
Co-authored papers 5
Sunnybrook Research Institute, University of Toronto
Co-authored papers 5
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 5
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 5
Oregon Health and Science University
Co-authored papers 5
Mayo Clinic Rochester
Co-authored papers 5
University of Utah
Co-authored papers 5
The University of Texas Southwestern Medical Center
Co-authored papers 4
University of California San Diego
Co-authored papers 4
Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine
Co-authored papers 4
Banner Alzheimer's Institute
Co-authored papers 4
University of Pittsburgh
Co-authored papers 4