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Author Details

Kristine R Crews
St. Jude Children's Research Hospital
2001
111
42
PMIDPaper TitleJournal TitlePublished Year
36824825Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures.bioRxiv2023
37986997Biologic and clinical features of childhood gamma delta T-ALL: identification of STAG2/LMO2 γδ T-ALL as an extremely high risk leukemia in the very young.medRxiv2023
37575398Ex vivo Drug Sensitivity Imaging-based Platform for Primary Acute Lymphoblastic Leukemia Cells.Bio Protoc2023
37729596Prognostic and Pharmacotypic Heterogeneity of Hyperdiploidy in Childhood ALL.J Clin Oncol2023
37303270An Introductory Tutorial on Cardiovascular Pharmacogenetics for Healthcare Providers.Clin Pharmacol Ther2023
37199744Pharmacokinetics and safety of bendamustine in the BEABOVP regimen for the treatment of pediatric patients with Hodgkin lymphoma.Cancer Chemother Pharmacol2023
36604538Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response.Nat Med2023
36798219Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment.medRxiv2023
34196166Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy.Haematologica2022
35671062Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia.Blood Adv2022
35537468Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.Annu Rev Genomics Hum Genet2022
36104354Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia.Nat Commun2022
36228116Clinician adherence to pharmacogenomics prescribing recommendations in clinical decision support alerts.J Am Med Inform Assoc2022
36028659Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia.Leukemia2022
36050548The genomic landscape of pediatric acute lymphoblastic leukemia.Nat Genet2022
34866312Dasatinib does not exacerbate dexamethasone-induced osteonecrosis in murine models of acute lymphoblastic leukemia therapy.Pediatr Blood Cancer2022
34693927Incorporating G6PD genotyping to identify patients with G6PD deficiency.Pharmacogenet Genomics2022
33124053Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.Clin Pharmacol Ther2021
33742760Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.Clin Transl Sci2021
33714976Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks.Leukemia2021
33598942Phase 1 study of bendamustine in combination with clofarabine, etoposide, and dexamethasone in pediatric patients with relapsed or refractory hematologic malignancies.Cancer2021
34103329Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia.Cancer Discov2021
34151288Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia.Nat Cancer2021
34318925Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network.Clin Pharmacol Ther2021
34239401Evaluation of Aminophylline for the Treatment of Acute Kidney Injury in Pediatric Hematology/Oncology Patients.J Pediatr Pharmacol Ther2021
33387367Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.Clin Pharmacol Ther2021
31341243Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination.Genet Med2020
33164984Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo.J Clin Invest2020
32809242Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia.Cancer2020
32710497Fluoroquinolone prophylaxis does not increase risk of neuropathy in children with acute lymphoblastic leukemia.Cancer Med2020
31612640Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia.Pediatr Blood Cancer2020
30467830The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.Clin Pharmacol Ther2019
31694285<i>GSTM1</i> and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload.J Clin Med2019
31188727Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.J Clin Oncol2019
30819904Leukemic presentation of ALK-positive anaplastic large cell lymphoma with a novel partner, poly(A) binding protein cytoplasmic 1 (PABPC1), responding to single-agent crizotinib.Haematologica2019
30405880Genome-wide association analysis identifies SNPs predictive of <i>in vitro</i> leukemic cell sensitivity to cytarabine in pediatric AML.Oncotarget2018
29866879Pentamidine for Prophylaxis against Pneumocystis jirovecii Pneumonia in Pediatric Oncology Patients Receiving Immunosuppressive Chemotherapy.Antimicrob Agents Chemother2018
30088438Comprehensive Ara-C SNP score predicts leukemic cell intracellular ara-CTP levels in pediatric acute myeloid leukemia patients.Pharmacogenomics2018
27564568Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.Clin Pharmacol Ther2017
28274984Development of a postgraduate year 2 pharmacy residency in clinical pharmacogenetics.Am J Health Syst Pharm2017
27618250An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine-Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia.Clin Pharmacol Ther2017
27967321The impact of the UGT1A1*60 allele on bilirubin serum concentrations.Pharmacogenomics2017
26704670Vincristine pharmacogenomics: 'winner's curse' or a different phenotype?Pharmacogenet Genomics2016
26488798Reply to: Glucarpidase for the Treatment of Methotrexate-Induced Renal Dysfunction and Delayed Methotrexate Excretion.Pediatr Blood Cancer2016
26366682Clinical significance of in vivo cytarabine-induced gene expression signature in AML.Leuk Lymphoma2016
27766934CC-PROMISE effectively integrates two forms of molecular data with multiple biologically related endpoints.BMC Bioinformatics2016
27311679Comparison of genome sequencing and clinical genotyping for pharmacogenes.Clin Pharmacol Ther2016
27335380Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.Pediatrics2016
25292429Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers.Annu Rev Pharmacol Toxicol2015
25938942NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.Nat Genet2015
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Collaborators

Departments of Pharmaceutical Sciences.
Co-authored papers 51
Departments of Oncology. St. Jude Children's Research Hospital
Co-authored papers 41
St. Jude Children's Research Hospital
Co-authored papers 35
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Co-authored papers 22
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Co-authored papers 21
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Co-authored papers 16
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Co-authored papers 16
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Co-authored papers 13
St. Jude Children's Research Hospital Memphis
Co-authored papers 13
Medical College of Wisconsin
Co-authored papers 12
University of Chinese Academy of Sciences
Co-authored papers 10
College of Nursing
Co-authored papers 9
St. Jude Children's Research Hospital
Co-authored papers 8
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Co-authored papers 8
Stanford University
Co-authored papers 7
H. Lee Moffitt Cancer Center and Research Institute
Co-authored papers 7
The University of Texas Health Science Center at San Antonio
Co-authored papers 7
The University of Texas MD Anderson Cancer Center
Co-authored papers 6
University of Tennessee Health Science Center
Co-authored papers 6
The University of Texas MD Anderson Cancer Center
Co-authored papers 6
St. Jude Children's Research Hospital
Co-authored papers 5
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Co-authored papers 5
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University of Chicago
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St. Jude Children's Research Hospital
Co-authored papers 5
Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham
Co-authored papers 4
Stanford University
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Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital
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Children's Hospital of Philadelphia
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