Author details

Full Name

Gordon C K Roberts

Affiliation

Leicester Institute of Structural and Chemical Biology, University of Leicester

ORCID

Career Start Year

1969

Papers

240

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
29475945	Solution structure of the cytochrome P450 reductase-cytochrome <i>c</i> complex determined by neutron scattering.	J Biol Chem	2018
28852004	Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase.	Sci Rep	2017
27235401	The Role of Active Site Flexible Loops in Catalysis and of Zinc in Conformational Stability of Bacillus cereus 569/H/9 Î²-Lactamase.	J Biol Chem	2016
28510175	The role of protein dynamics in allosteric effects-introduction.	Biophys Rev	2015
23838816	Complete Â¹H, Â¹âµN, and Â¹Â³C resonance assignments of Bacillus cereus metallo-Î²-lactamase and its complex with the inhibitor R-thiomandelic acid.	Biomol NMR Assign	2014
24696003	A variety of roles for versatile zinc in metallo-Î²-lactamases.	Metallomics	2014
23389036	RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.	J Biol Chem	2013
24059435	Solution structures of the Bacillus cereus metallo-Î²-lactamase BcII and its complex with the broad spectrum inhibitor R-thiomandelic acid.	Biochem J	2013
23911089	Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase.	Structure	2013
22955930	In support of the BMRB.	Nat Struct Mol Biol	2012
21240430	Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis.	Metallomics	2011
21688358	Detection of a protein conformational equilibrium by electrospray ionisation-ion mobility-mass spectrometry.	Angew Chem Int Ed Engl	2011
20399778	The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.	FEBS Lett	2010
20947018	The Structure of the talin head reveals a novel extended conformation of the FERM domain.	Structure	2010
20879989	Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4.	Biochem J	2010
20610383	Central region of talin has a unique fold that binds vinculin and actin.	J Biol Chem	2010
20150896	Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.	EMBO J	2010
19297334	The structure of an interdomain complex that regulates talin activity.	J Biol Chem	2009
19858215	Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.	J Biol Chem	2009
19665032	Positively cooperative binding of zinc ions to Bacillus cereus 569/H/9 beta-lactamase II suggests that the binuclear enzyme is the only relevant form for catalysis.	J Mol Biol	2009
19655048	Structural and biophysical properties of the integrin-associated cytoskeletal protein talin.	Biophys Rev	2009
19804783	The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.	J Mol Biol	2009
19176533	Structural determinants of integrin binding to the talin rod.	J Biol Chem	2009
18026129	Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.	Br J Pharmacol	2008
19636914	NMR assignment of the C-terminal actin-binding domain of talin.	Biomol NMR Assign	2008
18563261	Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.	Org Biomol Chem	2008
18638481	Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.	J Mol Biol	2008
18645035	Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.	Drug Metab Dispos	2008
18157087	The structure of the C-terminal actin-binding domain of talin.	EMBO J	2008
17868686	Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.	J Mol Biol	2007
16698891	In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.	Drug Metab Dispos	2006
17052239	Folding and unfolding for binding: large-scale protein dynamics in protein-protein interactions.	Biochem Soc Trans	2006
16415122	In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.	Drug Metab Dispos	2006
16407302	The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.	J Biol Chem	2006
16460027	Structural and dynamic characterization of a vinculin binding site in the talin rod.	Biochemistry	2006
15642262	A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.	Structure	2005
16135522	Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.	J Biol Chem	2005
16162505	Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.	J Biol Chem	2005
14992686	Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.	Biochem J	2004
15272303	Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.	EMBO J	2004
15481972	Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.	J Med Chem	2004
12446689	Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.	J Biol Chem	2003
12583753	Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process.	Org Lett	2003
12787027	Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.	Eur J Biochem	2003
12782621	Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain.	J Biol Chem	2003
12773143	Electron transfer in human cytochrome P450 reductase.	Biochem Soc Trans	2003
12724330	The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding.	J Biol Chem	2003
12482324	Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.	Biochem J	2003
11926825	Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.	Biochemistry	2002
12102632	DNA adducts formed from 4-hydroxytamoxifen are more mutagenic than those formed by alpha-acetoxytamoxifen in a shuttle vector target gene replicated in human Ad293 cells.	Biochemistry	2002

1 - 50 of 240

Alice Dawson

University of Dundee

Career Start Year 2002

Number of shared co-authors 0

Ronald D Seidel

Albert Einstein College of Medicine

Career Start Year 2001

Number of shared co-authors 2

Luigi Di Costanzo

University of Naples Federico II

Career Start Year 2000

Number of shared co-authors 2

Anthony P Duff

Bragg Institute

Career Start Year 2000

Number of shared co-authors 2

Igor Zhukov

Institute of Biochemistry and Biophysics, Polish Academy of Sciences

Career Start Year 1999

Number of shared co-authors 1

Rodrigo J Carbajo

Oncology R&D

Career Start Year 1997

Number of shared co-authors 2

Ram??n Campos-Olivas

Spanish National Cancer Research Centre (CNIO)

Career Start Year 1995

Number of shared co-authors 3

Volker D??tsch

Institute for Biophysical Chemistry, Goethe-University

Career Start Year 1995

Number of shared co-authors 6

John R Cort

Pacific Northwest National Laboratory

Career Start Year 1994

Number of shared co-authors 1

Michael A Kennedy

Miami University

Career Start Year 1993

Number of shared co-authors 6

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 1

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Career Start Year 1989

Number of shared co-authors 3

David E Timm

Lilly Research Laboratories

Career Start Year 1988

Number of shared co-authors 1

Raymond C Stevens

iHuman Institute, ShanghaiTech University

Career Start Year 1988

Number of shared co-authors 4

Vladimir N Malashkevich

Albert Einstein College of Medicine

Career Start Year 1982

Number of shared co-authors 1

Peter Bayer

University of Duisburg-Essen

Career Start Year 1981

Number of shared co-authors 3

Gaetano T Montelione

Rensselaer Polytechnic Institute

Career Start Year 1981

Number of shared co-authors 14

Hans J Vogel

University of Calgary

Career Start Year 1979

Number of shared co-authors 1

Eldon L Ulrich

University of Wisconsin-Madison

Career Start Year 1975

Number of shared co-authors 15

Martino Bolognesi

University of Milano

Career Start Year 1975

Number of shared co-authors 2

George N Phillips

Rice University

Career Start Year 1974

Number of shared co-authors 5

Douglas C Rees

Howard Hughes Medical Institute, California Institute of Technology

Career Start Year 1974

Number of shared co-authors 2

Dino Moras

Laboratory IGBMC (Institute of Genetics and of Molecular and Cellular Biology)

Career Start Year 1973

Number of shared co-authors 3

Jules Mitchell Guss

The University of Sydney

Career Start Year 1973

Number of shared co-authors 3

Joel L Sussman

Weizmann Institute of Science

Career Start Year 1971

Number of shared co-authors 6

Robert J Fletterick

University of California San Francisco

Career Start Year 1971

Number of shared co-authors 4

David Cowburn

Albert Einstein College of Medicine

Career Start Year 1969

Number of shared co-authors 4

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 1

Sung-Hou Kim

University of California berkeley

Career Start Year 1967

Number of shared co-authors 3

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 3

row(s) 1 - 30 of 30

Lu-Yun Lian

Institute of Systems, The University of Liverpool

Co-authored papers 37

Igor L Barsukov

Institute of Integrative Biology, University of Liverpool

Co-authored papers 31

Angela M Gronenborn

University of Pittsburgh

Co-authored papers 11

Alexander P Golovanov

The University of Manchester

Co-authored papers 4

Iain D Campbell

University of Oxford

Co-authored papers 4

Thomas A Frenkiel

The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute

Co-authored papers 4

Linda J Van Eldik

University of Kentucky

Co-authored papers 3

Robert Kaptein

Utrecht University

Co-authored papers 3

Michael G Joyce

Co-authored papers 2

Alan R Fersht

Medical Research Council Laboratory of Molecular Biology

Co-authored papers 2

Anne Martel

Institut Laue-Langevin (ILL)

Co-authored papers 2

Anthony Watts

Oxford University

Co-authored papers 2

Rolf Boelens

Utrecht University

Co-authored papers 2

Chien Ho

Carnegie Mellon University

Co-authored papers 2

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

Oliver F Lange

Center for Integrated Protein Science, Technische Universitat Munchen

Co-authored papers 1

Josep Rizo

University of Texas Southwestern Medical Center

Co-authored papers 1

Mike P Williamson

The University of Sheffield

Co-authored papers 1

Mark H Ginsberg

University of California

Co-authored papers 1

David E Shaw

Columbia University

Co-authored papers 1

Ad Bax

National Institutes of Health

Co-authored papers 1

Patrick C A van der Wel

Zernike Institute for Advanced Materials, University of Groningen

Co-authored papers 1

David Middleton

Co-authored papers 1

Ioannis Vakonakis

University of Oxford

Co-authored papers 1

Ernest D Laue

University of Cambridge

Co-authored papers 1

Gordon S Rule

Carnegie Mellon University

Co-authored papers 1

Stephen Matthews

Imperial College London

Co-authored papers 1

Toshimichi Fujiwara

Institute for Protein Research, Osaka University

Co-authored papers 1

Pei Tang

Sichuan University

Co-authored papers 1

Joern Werner

Co-authored papers 1

1 - 30

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