Author details

Full Name

Lily Q Dong

Affiliation

ORCID

Career Start Year

1997

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36917279	Upregulated TGF-Î²1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling.		2023
34730111	LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.	Journal of Clinical Investigation	2021
34162682	Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration.	Diabetes	2021
34264867	The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis.	JCI insight	2021
32986862	Identification and characterization of a novel adiponectin receptor agonist adipo anti-inflammation agonist and its anti-inflammatory effects in vitro and in vivo.	Br J Pharmacol	2021
32789574	Anti-inflammatory and anti-proliferative action of adiponectin mediated by insulin signaling cascade in human vascular smooth muscle cells.	Molecular Biology Reports	2020
32444826	Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice.	Communications Biology	2020
33041270	APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells.	Proceedings of the Japan Academy Series B: Physical and Biological Sciences	2020
31060900	DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.	eBioMedicine	2019
31624249	The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner.	Nature Communications	2019
31554182	Potential Roles of Adiponectin Isoforms in Human Obesity with Delayed Wound Healing.	Cells	2019
30791996	Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.	Kidney International	2019
29483192	Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function.	Journal of Biological Chemistry	2018
30250638	A new drug combination significantly reduces kidney tumor progression in kidney mouse model.	Oncotarget	2018
28232481	Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance.	FASEB Journal	2017
28860308	Erratum.	FASEB Journal	2017
29087318	DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.	Proceedings of the National Academy of Sciences of the United States of America	2017
26445298	Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.	J Cell Physiol	2016
26993044	Adiponectin signaling and function in insulin target tissues.	Journal of Molecular Cell Biology	2016
27207533	Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor Î±.		2016
26700098	Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.	Trends in Pharmacological Sciences	2016
25187480	Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes.	Stem Cells	2015
25739441	Endoplasmic reticulum (ER) localization is critical for DsbA-L protein to suppress ER stress and adiponectin down-regulation in adipocytes.	Journal of Biological Chemistry	2015
24780611	Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice.	Am J Physiol Endocrinol Metab	2014
24813896	APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.	Cell Reports	2014
24746805	Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.		2014
24740400	Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.	PLoS ONE	2014
23640763	Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis.	European Journal of Immunology	2013
23793716	Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function.	Diabetologia	2013
23131847	Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis.	Science Signaling	2012
22807031	Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance.		2012
22685300	Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.	Journal of Biological Chemistry	2012
22570332	The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism.	Mol Endocrinol	2012
21835890	APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway.	Molecular Endocrinology	2011
21300805	Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.	J Biol Chem	2011
20980258	Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L.	Journal of Biological Chemistry	2011
20978232	APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway.	American Journal of Physiology - Endocrinology and Metabolism	2011
21562756	Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling.	Diabetologia	2011
20699416	DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin downregulation.		2010
20851890	Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR.	Journal of Biological Chemistry	2010
18854421	APPL1: role in adiponectin signaling and beyond.	American Journal of Physiology - Endocrinology and Metabolism	2009
19047061	Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.	Journal of Biological Chemistry	2009
19541767	Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance.	Molecular Pharmacology	2009
19240254	Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.	American Journal of Physiology - Endocrinology and Metabolism	2009
19661063	Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.	Journal of Biological Chemistry	2009
19520843	Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.	Journal of Biological Chemistry	2009
19011089	A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization.	Proceedings of the National Academy of Sciences of the United States of America	2008
17620412	Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.	Molecular and Cellular Biology	2007
17502098	Crystal structures of the BAR-PH and PTB domains of human APPL1.	Structure	2007
17244624	Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1.	J Biol Chem	2007