Author details

Full Name

Eleftheria Zeggini

Affiliation

ORCID

Career Start Year

2001

Papers

296

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
36349687	Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing.	Hum Mol Genet	2023
36137835	Insights from multi-omics integration in complex disease primary tissues.	Trends in Genetics	2023
37669986	Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.	Nat Commun	2023
37749248	Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.	Nat Genet	2023
37579195	Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis.	Genetics	2023
37905000	Genomic insights into the comorbidity between type 2 diabetes and schizophrenia.	medRxiv	2023
37903942	GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal.		2023
37639939	Genome-wide association analysis of cystatin-C kidney function in continental Africa.	EBioMedicine	2023
37975894	Epigenomic profiling of the infrapatellar fat pad in osteoarthritis.		2023
37778719	Genome-wide meta-analysis of 92 cardiometabolic protein serum levels.		2023
37619450	The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.	EBioMedicine	2023
37550624	Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases.	Clin Proteomics	2023
37034613	Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders.	Res Sq	2023
36649380	A novel splice-affecting variant with large population impact on diabetes in Greenland.		2023
36824751	Genetic mechanisms of 184 neuro-related proteins in human plasma.	medRxiv	2023
37448981	Bridging the diversity gap: Analytical and study design considerations for improving the accuracy of trans-ancestry genetic prediction.	HGG Adv	2023
37316478	Unravelling the genetic architecture of human complex traits through whole genome sequencing.		2023
37433298	Genetic underpinning of the comorbidity between type 2 diabetes and osteoarthritis.	Am J Hum Genet	2023
37428931	NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis.		2023
36662418	A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.	Arthritis Rheumatol	2023
37096546	Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization.	Arthritis Rheumatol	2023
34750308	Insights into the molecular landscape of osteoarthritis in human tissues.	Current Opinion in Rheumatology	2022
35387486	Genetic Landscape of the ACE2 Coronavirus Receptor.	Circulation	2022
35644035	Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores.	Arthritis Rheumatol	2022
35504531	Gene-based whole genome sequencing meta-analysis of 250 circulating proteins in three isolated European populations.	Molecular Metabolism	2022
35679866	An epigenome-wide view of osteoarthritis in primary tissues.	Am J Hum Genet	2022
35551307	Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.	Nat Genet	2022
36536132	Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity.		2022
35064169	Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations.	Sci Rep	2022
34897459	Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index.	Int J Epidemiol	2022
35088088	A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis.	Human Molecular Genetics	2022
34857772	Mapping the serum proteome to neurological diseases using whole genome sequencing.	Nat Commun	2021
32064741	Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.	Addict Biol	2021
32393986	The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.	Calcified Tissue International	2021
33903094	Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.	Annals of the Rheumatic Diseases	2021
33473114	Accelerating functional gene discovery in osteoarthritis.	Nat Commun	2021
33953184	Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.	Nat Commun	2021
34050183	Publisher Correction: Accelerating functional gene discovery in osteoarthritis.	Nat Commun	2021
33727701	Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.	Nat Genet	2021
33558538	Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups.	Scientific Reports	2021
33055079	Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify <i>WNT9A</i> as novel osteoarthritis gene.	Ann Rheum Dis	2021
31520489	Population-wide copy number variation calling using variant call format files from 6,898 individuals.	Genet Epidemiol	2020
36474678	The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach.		2020
31718940	Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci.	Trends in Molecular Medicine	2020
32442404	Biomedical Research Goes Viral: Dangers and Opportunities.	Cell	2020
32492392	Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.	Cell Metab	2020
32150548	The influence of rare variants in circulating metabolic biomarkers.	PLoS Genet	2020
33045005	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.	PLoS Genet	2020
33303764	Whole-genome sequencing analysis of the cardiometabolic proteome.	Nature Communications	2020