Author details

Full Name

Jia-Ren Lin

Affiliation

ORCID

Career Start Year

2003

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37349501	High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers.		2023
37928169	3D multiplexed tissue imaging reconstruction and optimized region of interest (ROI) selection through deep learning model of channels embedding.	Front Bioinform	2023
37961235	Quality Control for Single Cell Analysis of High-plex Tissue Profiles using CyLinter.		2023
37450351	Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer.	Cancer Res	2023
37066161	Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence.		2023
37059105	Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma.		2023
37352344	Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells.		2023
36669472	Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer.	Cell	2023
34750536	Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data.	Nature Biomedical Engineering	2022
35973991	Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.	Nat Commun	2022
36173860	Oncometabolite d-2HG alters T cell metabolism to impair CD8<sup>+</sup> T cell function.	Science	2022
35617956	A human breast atlas integrating single-cell proteomics and transcriptomics.	Dev Cell	2022
35292783	Temporal and spatial topography of cell proliferation in cancer.	Nature Cell Biology	2022
34606456	Scope2Screen: Focus+Context Techniques for Pathology Tumor Assessment in Multivariate Image Data.		2022
34824477	MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging.	Nat Methods	2022
33451979	HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor.	Clin Cancer Res	2021
33738458	Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.	Nat Cancer	2021
33941922	Evolution of delayed resistance to immunotherapy in a melanoma responder.	Nat Med	2021
32572264	A single-cell landscape of high-grade serous ovarian cancer.	Nat Med	2020
32133433	Response and mechanisms of resistance to larotrectinib and selitrectinib in metastatic undifferentiated sarcoma harboring oncogenic fusion of .	JCO Precision Oncology	2020
32601199	Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.	Proc Natl Acad Sci U S A	2020
31534232	Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.		2019
31848351	Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer.	Sci Data	2019
31809500	Inferring reaction network structure from single-cell, multiplex data, using toric systems theory.	PLoS Computational Biology	2019
31160565	Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.	Nat Commun	2019
30801050	Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade.	JCO Precis Oncol	2018
30388455	A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.	Cell	2018
30571695	Determinants of drug-target interactions at the single cell level.	PLoS Computational Biology	2018
29993362	Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes.	eLife	2018
29509940	Multiplexed immunofluorescence reveals potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma.	Neuro Oncol	2018
29466723	Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.	Cell Rep	2018
29199020	The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.	Cell Syst	2018
28005393	Multiplexed Single-Cell Imaging: Past, Present, and Future.	Assay and Drug Development Technologies	2017
28069687	Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.	Mol Syst Biol	2017
27925668	Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging.	Current protocols in chemical biology	2016
27124452	Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.	Science	2016
26399630	Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method.	Nature Communications	2015
25023518	DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.	Journal of Cell Biology	2014
23973373	NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.	Mol Cell	2013
24119401	Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle.	Molecular Cell	2013
22206868	A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision.	Molecular Cell	2012
21396873	SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.	Mol Cell	2011
18577580	eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions.	J Cell Sci	2008
17320499	An application of bioinformatics and text mining to the discovery of novel genes related to bone biology.	Bone	2007
16229269	[Inhibitory effect of potential metastasis in SGC-7901 cells induced by beta-ionone].	Wei Sheng Yan Jiu	2005
15616583	Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.	EMBO J	2005
14600263	Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase.	Journal of Cell Science	2003