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Author Details

Karen Cerosaletti
Center for Translational Immunology
1985
66
29
PMIDPaper TitleJournal TitlePublished Year
36961507<i>PTPN22</i> R620W gene editing in T cells enhances low-avidity TCR responses.Elife2023
37758901Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.Commun Biol2023
37751304Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes.JCI Insight2023
37886513Self-reactive germline-like TCR alpha chains shared between blood and pancreas.Res Sq2023
34593707Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.Crit Care Med2022
35911690IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation.Front Immunol2022
36197963Pancreatic islet-specific engineered T<sub>regs</sub> exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.Sci Transl Med2022
34981778HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.J Clin Invest2022
34342578Endomembrane targeting of human OAS1 p46 augments antiviral activity.Elife2021
33558373Conserved IFN Signature between Adult and Pediatric Eosinophilic Esophagitis.J Immunol2021
34806648Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes.JCI Insight2021
34747368IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.JCI Insight2021
34740959The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.J Immunol2021
31557315In-vivo assessment of T cell kinetics in individuals at risk for type 1 diabetes.Clin Exp Immunol2020
30825465The MALT1 locus and peanut avoidance in the risk for peanut allergy.J Allergy Clin Immunol2019
31231380High <i>TLR7</i> Expression Drives the Expansion of CD19<sup>+</sup>CD24<sup>hi</sup>CD38<sup>hi</sup> Transitional B Cells and Autoantibody Production in SLE Patients.Front Immunol2019
31221801Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances.Diabetes2019
30894366Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression.Diabetes2019
30740104The <i>TYK2</i>-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.Front Immunol2019
30888520Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.Curr Diab Rep2019
30885949Erratum. Genetics coming of age in type 1 diabetes. Diabetes Care 2019;42:189-191.Diabetes Care2019
29429978Islet-reactive CD8<sup>+</sup> T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.Sci Immunol2018
28553952The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.Nat Immunol2017
28566371Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4<sup>+</sup> T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.J Immunol2017
28645874Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.Clin Immunol2017
27629486Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.Sci Transl Med2016
27816669The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans.Clin Immunol2016
26240375ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.Nucleic Acids Res2015
24576418Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance.Clin Immunol2014
23146902NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks.Oncogene2013
24376757Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.PLoS One2013
24163407A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping.J Immunol2013
23363979In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling.Sci Transl Med2013
21945395Ultra-sensitive detection of rare T cell clones.J Immunol Methods2012
23804260Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.Rev Diabet Stud2012
21179116An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells.Genes Immun2011
19875613Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.Diabetes2010
19075003Nuclear export of NBN is required for normal cellular responses to radiation.Mol Cell Biol2009
19418549A novel mutation in a family with DNA ligase IV deficiency syndrome.Pediatr Blood Cancer2009
18664457Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.Hum Mol Genet2008
16478990Active role for nibrin in the kinetics of atm activation.Mol Cell Biol2006
17124492ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.EMBO J2006
16088910A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome.Am J Med Genet A2005
15234984Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.J Biol Chem2004
12679336Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.J Biol Chem2003
14533197Functional delivery of large genomic DNA to human cells with a peptide-lipid vector.J Gene Med2003
12621246Medulloblastoma with adverse reaction to radiation therapy in nijmegen breakage syndrome.J Pediatr Hematol Oncol2003
11953735Nijmegen breakage syndrome: clinical characteristics and mutation analysis in eight unrelated Russian families.J Pediatr2002
12353271Mutations and molecular variants of the NBS1 gene in non-Hodgkin lymphoma.Genes Chromosomes Cancer2002
11389166Nijmegen breakage syndrome in a Dutch patient not resulting from a defect in NBS1.J Med Genet2001
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Collaborators

Patrick Concannon
Co-authored papers 22
Jane H Buckner
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 19
Carla J Greenbaum
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 13
Sarah Alice Long
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 12
Cate Speake
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 9
Gerald T Nepom
Wash Benaroya Research Institute at Virginia Mason
Co-authored papers 6
Richard A Gatti
Co-authored papers 6
Peter S Linsley
8Benaroya Research Institute
Co-authored papers 5
Fariba Barahmand-Pour
Benaroya Research Institute at Virginia Mason
Co-authored papers 4
Janice Chen
Center for Translational Research
Co-authored papers 4
Elisavet Serti
The Henry Jackson Foundation.
Co-authored papers 4
Elisa Balmas
Center for Translational Immunology
Co-authored papers 3
Vivian H Gersuk
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 3
Kathleen C Barnes
Co-authored papers 2
Hannah A DeBerg
Benaroya Research Institute at Virginia Mason
Co-authored papers 2
Todd M Brusko
College of Medicine, Diabetes Institute, University of Florida
Co-authored papers 2
Kevan C Herold
Yale University
Co-authored papers 2
Helena Reijonen
City of Hope Medical Center, Beckman Research Institute
Co-authored papers 2
Sara A Murray
Novo Nordisk Research Center Seattle
Co-authored papers 2
Mario G Rosasco
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 2
Ingo Ruczinski
Co-authored papers 2
William W Kwok
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 2
Michael Gale
Center for Innate Immunity and Immune Disease, University of Washington
Co-authored papers 2
Carmen Mikacenic
Benaroya Research Institute at Virginia Mason
Co-authored papers 2
Erik Wambre
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Co-authored papers 1
James A Eddy
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Raphael Gottardo
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Release 1.2