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Author Details

Dimitris P Xirodimas
University of Montpellier, CNRS
1999
51
29
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36446972A Mass Spectrometry-Based Strategy for Mapping Modification Sites for the Ubiquitin-Like Modifier NEDD8.Methods Mol Biol2023
37552601Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses.Cell Rep2023
37000881Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly.Sci Adv2023
35078718Mixed in chains: NEDD8 polymers in the Protein Quality Control system.Semin Cell Dev Biol2022
33472076Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.Cell Rep2021
34156462The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.Biochem Soc Trans2021
34153521Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.Mol Metab2021
32454028Antibody RING-Mediated Destruction of Endogenous Proteins.Mol Cell2020
31577950The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity.Cell Rep2019
30024791Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function.FASEB J2019
30349034NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress.Nat Commun2018
28199849Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes.Cell Rep2017
25867069The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.Oncogene2016
27901050The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity.Sci Rep2016
25504797Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic.Endocr Relat Cancer2015
25650664Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.Oncotarget2015
25762659PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.J Neurosci2015
23134341DNA-binding regulates site-specific ubiquitination of IRF-1.Biochem J2013
23907157DUBs "found in translation": USP15 controls stability of newly synthesized REST.Cell Cycle2013
22095636Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.Hepatology2012
22527944Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling.Bull Math Biol2012
22487680The p53 isoforms are differentially modified by Mdm2.Cell Cycle2012
22350881Isolation of NEDDylated proteins in human cells.Methods Mol Biol2012
22370482The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions.Cell Cycle2012
22081073Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner.Oncogene2012
22038470Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.Mol Cell Proteomics2012
21184761Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways.J Theor Biol2011
21852789In the family with ubiquitin.EMBO Rep2011
21874007Stable-isotope labeling with amino acids in nematodes.Nat Methods2011
21655279The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe.PLoS One2011
20101219NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways.Oncogene2010
21222278Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53.Subcell Biochem2010
20696840Mechanism of hypoxia-induced NF-kappaB.Mol Cell Biol2010
20554519Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation.J Biol Chem2010
19713960Regulation of nucleolar signalling to p53 through NEDDylation of L11.EMBO Rep2009
19730420Detection of protein SUMOylation in vivo.Nat Protoc2009
18274552Ribosomal proteins are targets for the NEDD8 pathway.EMBO Rep2008
18793140Novel substrates and functions for the ubiquitin-like molecule NEDD8.Biochem Soc Trans2008
18793136Much to know about proteolysis: intricate proteolytic machineries compromise essential cellular functions.Biochem Soc Trans2008
17290220The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.EMBO J2007
15775960Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.EMBO J2005
16131611p53 isoforms can regulate p53 transcriptional activity.Genes Dev2005
15355988p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.J Biol Chem2004
15242646Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.Cell2004
15280377Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.J Biol Chem2004
12297306P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.FEBS Lett2002
11526482Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.Oncogene2001
11606419Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.EMBO Rep2001
11597128Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.Exp Cell Res2001
10488156Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling.J Biol Chem1999
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Collaborators

Mark Larance
The University of Sydney
Co-authored papers 3
Angus I Lamond
University of Dundee
Co-authored papers 3
Mathias Uhl??n
KTH Royal Institute of Technology
Co-authored papers 1
Kathryn J Kirkwood
Western General Hospital
Co-authored papers 1
Colin Gordon
Clinical and Health Sciences, University of South Australia
Co-authored papers 1
Rod Bremner
University of Toronto
Co-authored papers 1
Ivan Matic
Max Planck Institute for Biology of Ageing
Co-authored papers 1
Emma Lundberg (CM4AI)
Stanford University
Co-authored papers 1
Release 1.2