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Author Details

Andrey Loboda
Merck & Co., Inc.
1998
66
36
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36709038Associations of tissue tumor mutational burden and mutational status with clinical outcomes in KEYNOTE-042: pembrolizumab versus chemotherapy for advanced PD-L1-positive NSCLC.Ann Oncol2023
34965943Transcriptomic Determinants of Response to Pembrolizumab Monotherapy across Solid Tumor Types.Clin Cancer Res2022
36793385Associations of Tissue Tumor Mutational Burden and Mutational Status With Clinical Outcomes With Pembrolizumab Plus Chemotherapy Versus Chemotherapy For Metastatic NSCLC.JTO Clin Res Rep2022
35982220STUB1 is an intracellular checkpoint for interferon gamma sensing.Sci Rep2022
35101941Tumor mutational burden predicts the efficacy of pembrolizumab monotherapy: a pan-tumor retrospective analysis of participants with advanced solid tumors.J Immunother Cancer2022
35247908Putative Biomarkers of Clinical Benefit With Pembrolizumab in Advanced Urothelial Cancer: Results from the KEYNOTE-045 and KEYNOTE-052 Landmark Trials.Clin Cancer Res2022
35272617An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy.BMC Cancer2022
34965960Reverse Translating Molecular Determinants of Anti-Programmed Death 1 Immunotherapy Response in Mouse Syngeneic Tumor Models.Mol Cancer Ther2022
33372059ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells.Mol Cancer Res2021
33796403Combination of EP<sub>4</sub> antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells.Oncoimmunology2021
33566112Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice.J Exp Med2021
32119089Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities.Toxicol Sci2020
32075803Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma.Cancer Immunol Res2020
30442684Molecular Profiling of Cohorts of Tumor Samples to Guide Clinical Development of Pembrolizumab as Monotherapy.Clin Cancer Res2019
31015202Repurposing EGFR Inhibitor Utility in Colorectal Cancer in Mutant <i>APC</i> and <i>TP53</i> Subpopulations.Cancer Epidemiol Biomarkers Prev2019
29016887Phase I/II trial of vorinostat combined with temozolomide and radiation therapy for newly diagnosed glioblastoma: results of Alliance N0874/ABTC 02.Neuro Oncol2018
30013197Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer.Nat Med2018
30349641Characterization of murine CEACAM1 <i>in vivo</i> reveals low expression on CD8<sup>+</sup> T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1.Oncotarget2018
30309915Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy.Science2018
27681944Dalotuzumab in chemorefractory KRAS exon 2 mutant colorectal cancer: Results from a randomised phase II/III trial.Int J Cancer2017
29136508Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.Cancer Cell2017
28650338IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.J Clin Invest2017
27112350Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
26587671Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.J Bone Miner Res2016
26446941A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome.Clin Cancer Res2016
27302369A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC.Nat Commun2016
27256377High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide.Mol Cancer Ther2016
27461835Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.J Biomol Screen2016
27216421Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
26742691Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination.Nat Commun2016
26983881An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies.Mol Cancer Ther2016
26765077An accessible pharmacodynamic transcriptional biomarker for notch target engagement.Clin Pharmacol Ther2016
25894828Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.Nat Med2015
26405092A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer.J Natl Cancer Inst2015
26296641Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics.J Natl Cancer Inst2015
25220188Senescence-associated-gene signature identifies genes linked to age, prognosis, and progression of human gliomas.J Geriatr Oncol2014
25504080Pre-treatment whole blood gene expression is associated with 14-week response assessed by dynamic contrast enhanced magnetic resonance imaging in infliximab-treated rheumatoid arthritis patients.PLoS One2014
25407104Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing.Nat Commun2014
25289887MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.PLoS One2014
22903568Systems biology approach for new target and biomarker identification.Curr Top Microbiol Immunol2013
23788652Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma.Genome Res2013
22103427Transcriptional profiling of vaccine-induced immune responses in humans and non-human primates.Microb Biotechnol2012
23063831Scientific investigations into febrile reactions observed in the paediatric population following vaccination with a 2010 Southern Hemisphere Trivalent Influenza Vaccine.Vaccine2012
22445337Transcriptional architecture of the primate neocortex.Neuron2012
22623531Functional genomics identifies therapeutic targets for MYC-driven cancer.Proc Natl Acad Sci U S A2012
22547604Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.J Clin Oncol2012
21251323EMT is the dominant program in human colon cancer.BMC Med Genomics2011
22216330Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging.PLoS One2011
21703392Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling.Am J Pathol2011
21750698Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting.PLoS One2011
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Collaborators

Alexei A Podtelezhnikov
Genetics and Pharmacogenomics, Merck & Co., Inc.
Co-authored papers 8
Louise C Showe
The Wistar Institute
Co-authored papers 4
Jeeyun Lee
Samsung Medical Center, Sungkyunkwan University School of Medicine
Co-authored papers 3
John F Reilly
Goldfinch Bio Inc.
Co-authored papers 3
Kyoung-Mee Kim
Seoul National University College of Medicine
Co-authored papers 3
Antoni Ribas
University of California Los Angeles (university of california los angeles)
Co-authored papers 3
Christoph Reinhard
Lilly Research Laboratories
Co-authored papers 3
Victoria M Richon
Discovery and Preclinical Sciences
Co-authored papers 3
Ronghua Chen
Co-authored papers 3
Patrick Y Wen
Co-authored papers 2
Bruce L Miller
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Kurt M Lucin
Eastern Connecticut State University
Co-authored papers 2
Badri N Vardarajan
Columbia University Irving Medical Center, New York Presbyterian Hospital
Co-authored papers 2
Rosa Rademakers
University of Antwerp
Co-authored papers 2
Markus Britschgi
Roche Pharma Research and Early Development
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Ke Hao
Co-authored papers 2
Ruochun Huang
RayBiotech Inc., USA RayBiotech Inc.
Co-authored papers 2
NiCole A Finch
Mayo Clinic
Co-authored papers 2
Philipp A Jaeger
University of California
Co-authored papers 2
Eliezer Masliah
National Institute On Aging
Co-authored papers 2
Min Gew Choi
Research Institute, National Cancer Center
Co-authored papers 2
Jamie K Teer
H. Lee Moffitt Cancer Center and Research Institute
Co-authored papers 2
Anna Karydas
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Eric E Schadt
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Bradley F Boeve
Mayo Clinic Rochester
Co-authored papers 2
Elizabeth Head
University of California Irvine
Co-authored papers 2
Valur Emilsson
Co-authored papers 2
Neill R Graff-Radford
Mayo Clinic Florida
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Lindsay A Farrer
Boston University Chobanian & Avedisian School of Medicine
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Release 1.2