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Author Details

Paul J Hergenrother
University of Illinois at Urbana-Champaign
1995
176
46
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36470974Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies.Br J Cancer2023
37522838Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis.Cancer Res2023
37554223Phase I dose-escalation study of procaspase-activating compound-1 in combination with temozolomide in patients with recurrent high-grade astrocytomas.Neurooncol Adv2023
37950707IP-DNQ induces mitochondrial dysfunction and G2/M phase cell cycle arrest to selectively kill NQO1-positive pancreatic cancer cells.Antioxid Redox Signal2023
37993720Porin-independent accumulation in Pseudomonas enables antibiotic discovery.Nature2023
38051103Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.Cancer Res Commun2023
37738028The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma.Melanoma Res2023
37645737Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression.bioRxiv2023
37258040Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model.J Immunother Cancer2023
37126856A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain.ACS Chem Biol2023
35193963Role of internal loop dynamics in antibiotic permeability of outer membrane porins.Proc Natl Acad Sci U S A2022
35759775Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy.J Am Chem Soc2022
35814932Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity.RSC Med Chem2022
36032774An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with <i>In Vivo</i> Efficacy against Drug-Resistant Gram-Negative Infections.ACS Cent Sci2022
36163502Computational discovery of dynobactin antibiotics.Nat Microbiol2022
36188352Correction to "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with <i>In Vivo</i> Efficacy against Drug-Resistant Gram-Negative Infections".ACS Cent Sci2022
35119837Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture.ACS Chem Biol2022
34930786Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges.Cancer Discov2022
35080871Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer.J Med Chem2022
33228356Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums.ACS Infect Dis2021
33522241Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile.ACS Infect Dis2021
33531390A Phosphonate Natural Product Made by Pantoea ananatis is Necessary and Sufficient for the Hallmark Lesions of Onion Center Rot.mBio2021
33635073Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria.Acc Chem Res2021
34909143Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge.Chem Sci2021
34480129An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli.Nat Protoc2021
34246985Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy.Neoplasia2021
34216463Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients.Neuro Oncol2021
34320318Correction to "Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques".J Am Chem Soc2021
34290053A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.Sci Transl Med2021
34285231Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.Nat Commun2021
33973348Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity.Angew Chem Int Ed Engl2021
33464048Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques.J Am Chem Soc2021
32432858Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch.J Am Chem Soc2020
31740764Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens.Nat Microbiol2020
31793158Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations.Angew Chem Int Ed Engl2020
33034322Re-engineering natural products to engage new biological targets.Nat Prod Rep2020
29446459The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics.Ann N Y Acad Sci2019
31178257Editorial overview: From the iceman to modern medicine.Curr Opin Chem Biol2019
31260254Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential.ACS Chem Biol2019
31428936Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program.Acta Neuropathol2019
30859090Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers.Front Oncol2019
30976021Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.Sci Rep2019
31086302Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis.Nat Chem2019
30520639Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene.J Am Chem Soc2019
29443976How many human proteoforms are there?Nat Chem Biol2018
29909991Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation.Cell Chem Biol2018
29802227Going on offense against the gram-negative defense.Proc Natl Acad Sci U S A2018
30204451Preparation of Structurally Diverse Compounds from the Natural Product Lycorine.Org Lett2018
29899383Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death.Cell Death Differ2018
30296373Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma.ACS Chem Biol2018
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Collaborators

Gregory J Riggins
Co-authored papers 3
Joshua M Francis
Co-authored papers 2
Emad Tajkhorshid
University of Illinois at Urbana-Champaign
Co-authored papers 2
Nathan A Yates
University of Pittsburgh School of Medicine
Co-authored papers 1
Amelia Palermo
Co-authored papers 1
Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 1
Mathias Uhl??n
KTH Royal Institute of Technology
Co-authored papers 1
Stuart L Schreiber
Broad Institute
Co-authored papers 1
Vamsi K Mootha
Broad Institute of MIT and Harvard
Co-authored papers 1
James J Pesavento
Saint Mary's College of California
Co-authored papers 1
Jens Luebeck
University of California San Diego
Co-authored papers 1
Steven M Patrie
Northwestern University
Co-authored papers 1
Therese Wohlschlager
University of Salzburg
Co-authored papers 1
Michael C Jewett
Northwestern University
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Carolyn R Bertozzi
Stanford University
Co-authored papers 1
Ole N Jensen
VILLUM Center for Bioanalytical Sciences, University of Southern Denmark
Co-authored papers 1
Nicolas L Young
Baylor College of Medicine, USA Center for Precision Environmental Health
Co-authored papers 1
Mark S Baker
Macquarie University
Co-authored papers 1
Jeffrey A Kiefer
Co-authored papers 1
Jaume Mora
Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu
Co-authored papers 1
Finny G Kuruvilla
Co-authored papers 1
Sharon J Pitteri
Stanford University
Co-authored papers 1
Jeremy Gunawardena
Harvard Medical School
Co-authored papers 1
David R Walt
Brigham and Women's Hospital
Co-authored papers 1
Hans-Joachim Anders
University Hospital of the Ludwig Maximilians University Munich
Co-authored papers 1
Johanna Ten Hoeve
California Nanosystems Institute, University of California los angeles
Co-authored papers 1
Alexander R Ivanov
Barnett Institute of Chemical and Biological Analysis, Northeastern University
Co-authored papers 1
Gabriel Karin
David Geffen School of Medicine, University of California los angeles
Co-authored papers 1
Michael J MacCoss
University of Washington
Co-authored papers 1
Release 1.2