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Author Details

Harish Shankaran
Merck & Co.
2000
39
18
PMIDPaper TitleJournal TitlePublished Year
35058172Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.SLAS Discov2022
35058172Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.SLAS Discov2022
32851936A Surrogate Matrix-Based Approach Toward Multiplexed Quantitation of an sGC Stimulator and cGMP in Ocular Tissue and Plasma.Toxicol Pathol2021
32851936A Surrogate Matrix-Based Approach Toward Multiplexed Quantitation of an sGC Stimulator and cGMP in Ocular Tissue and Plasma.Toxicol Pathol2021
30649541A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.Toxicol Sci2019
30649541A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.Toxicol Sci2019
30868312Pharmacokinetic Properties of Humanized IgG1 and IgG4 Antibodies in Preclinical Species: Translational Evaluation.AAPS J2019
31485548Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis.Comput Toxicol2019
31485548Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis.Comput Toxicol2019
30868312Pharmacokinetic Properties of Humanized IgG1 and IgG4 Antibodies in Preclinical Species: Translational Evaluation.AAPS J2019
29126144Multiscale Mathematical Model of Drug-Induced Proximal Tubule Injury: Linking Urinary Biomarkers to Epithelial Cell Injury and Renal Dysfunction.Toxicol Sci2018
28941225Systems Pharmacology Model of Gastrointestinal Damage Predicts Species Differences and Optimizes Clinical Dosing Schedules.CPT Pharmacometrics Syst Pharmacol2018
29126144Multiscale Mathematical Model of Drug-Induced Proximal Tubule Injury: Linking Urinary Biomarkers to Epithelial Cell Injury and Renal Dysfunction.Toxicol Sci2018
28941225Systems Pharmacology Model of Gastrointestinal Damage Predicts Species Differences and Optimizes Clinical Dosing Schedules.CPT Pharmacometrics Syst Pharmacol2018
25315124Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells.Mol Biosyst2015
25315124Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells.Mol Biosyst2015
26293472Investigating nephrotoxicity of polymyxin derivatives by mapping renal distribution using mass spectrometry imaging.Chem Res Toxicol2015
26293472Investigating nephrotoxicity of polymyxin derivatives by mapping renal distribution using mass spectrometry imaging.Chem Res Toxicol2015
25068892ERK oscillation-dependent gene expression patterns and deregulation by stress response.Chem Res Toxicol2014
25068892ERK oscillation-dependent gene expression patterns and deregulation by stress response.Chem Res Toxicol2014
23732079Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels.Toxicol Appl Pharmacol2013
23990774Model-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3.PLoS Comput Biol2013
23925568Integrated experimental and computational approach to understand the effects of heavy ion radiation on skin homeostasis.Integr Biol (Camb)2013
23732079Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels.Toxicol Appl Pharmacol2013
23990774Model-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3.PLoS Comput Biol2013
23925568Integrated experimental and computational approach to understand the effects of heavy ion radiation on skin homeostasis.Integr Biol (Camb)2013
22380462Using imaging methods to interrogate radiation-induced cell signaling.Radiat Res2012
22351304Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: implications for medical exposures.Environ Mol Mutagen2012
22380462Using imaging methods to interrogate radiation-induced cell signaling.Radiat Res2012
22952062Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.Mol Biosyst2012
23071432Modeling dynamic regulatory processes in stroke.PLoS Comput Biol2012
22952062Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.Mol Biosyst2012
23071432Modeling dynamic regulatory processes in stroke.PLoS Comput Biol2012
22351304Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: implications for medical exposures.Environ Mol Mutagen2012
21187236Spatial aspects in biological system simulations.Methods Enzymol2011
21187236Spatial aspects in biological system simulations.Methods Enzymol2011
21557328Inhibition of ERK oscillations by ionizing radiation and reactive oxygen species.Mol Carcinog2011
22074594Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems.BMC Syst Biol2011
22074594Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems.BMC Syst Biol2011
21557328Inhibition of ERK oscillations by ionizing radiation and reactive oxygen species.Mol Carcinog2011
20016498Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells.J Invest Dermatol2010
20810275Oscillatory dynamics of the extracellular signal-regulated kinase pathway.Curr Opin Genet Dev2010
20458382Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.Mol Biosyst2010
20016498Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells.J Invest Dermatol2010
20810275Oscillatory dynamics of the extracellular signal-regulated kinase pathway.Curr Opin Genet Dev2010
20458382Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.Mol Biosyst2010
19878579HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells.BMC Cell Biol2009
19878579HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells.BMC Cell Biol2009
19953086Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.Mol Syst Biol2009
19953086Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.Mol Syst Biol2009
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Collaborators

Haluk Resat
Co-authored papers 11
H S Wiley
Co-authored papers 10
William B Chrisler
Co-authored papers 7
Yi Zhang
Co-authored papers 6
Lee K Opresko
Co-authored papers 6
Katrina M Waters
Pacific Northwest National Laboratory
Co-authored papers 4
Jason E McDermott
Pacific Northwest National Laboratory
Co-authored papers 2
Nikki Bollinger
Co-authored papers 2
Chunhong Gong
Co-authored papers 1
Jonathan A Ewald
Co-authored papers 1
Douglas A Lauffenburger
Massachusetts Institute of Technology
Co-authored papers 1
Sarah E Belisle
University of Washington
Co-authored papers 1
Susan C Tilton
Oregon State University
Co-authored papers 1
Anders B Dohlman
Co-authored papers 1
Gabriele Neuman
Co-authored papers 1
Carol L Sabourin
Battelle Memorial Institute
Co-authored papers 1
Jeremy L Muhlich
Co-authored papers 1
Michael G Katze
University of Washington
Co-authored papers 1
Amie J Eisfeld
Influenza Research Institute, University of Wisconsin-Madison
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Danielle L Ippolito
Co-authored papers 1
Michelle N Costa
Co-authored papers 1
Abhishek G Sathe
University of Minnesota
Co-authored papers 1
Yunbing Tan
Co-authored papers 1
Chengjun Li
Harbin Veterinary Research Institute
Co-authored papers 1
Lisa Truong
Incyte Research Institute, Incyte Corporation
Co-authored papers 1
Yoshihiro Kawaoka
Influenza Research Institute, University of Wisconsin
Co-authored papers 1
Robert L Tanguay
Cumming School of Medicine, University of Calgary
Co-authored papers 1
Release 1.2