|
| 37012496 | Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. | Nat Metab | 2023 |
| 37601869 | Splenic marginal zone lymphoma in Sweden 2000-2020: Increasing rituximab use and better survival in the elderly. | EJHaem | 2023 |
| 35228749 | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. | Nat Cancer | 2022 |
| 35737787 | Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. | Science | 2022 |
| 35732208 | Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir. | J Biol Chem | 2022 |
| 35603175 | FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors. | Front Immunol | 2022 |
| 35712863 | The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors. | ChemMedChem | 2022 |
| 34192523 | NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. | Cell Chem Biol | 2021 |
| 35844675 | Real-world data on treatment concepts in classical Hodgkin lymphoma in Sweden 2000-2014, focusing on patients aged >60 years. | EJHaem | 2021 |
| 33753169 | Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. | J Biol Chem | 2021 |
| 33889307 | High risk of cardiovascular side effects after treatment of Hodgkin's lymphoma - is there a need for intervention in long-term survivors? | Ups J Med Sci | 2021 |
| 31612478 | No excess long-term mortality in stage I-IIA Hodgkin lymphoma patients treated with ABVD and limited field radiotherapy. | Br J Haematol | 2020 |
| 31954130 | The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products. | J Mol Biol | 2020 |
| 33211885 | Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. | Nucleic Acids Res | 2020 |
| 33322045 | Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses. | Viruses | 2020 |
| 32690945 | Development of a chemical probe against NUDT15. | Nat Chem Biol | 2020 |
| 32571877 | Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. | J Biol Chem | 2020 |
| 32144205 | MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. | J Biol Chem | 2020 |
| 30614695 | Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana. | Biochemistry | 2019 |
| 31676755 | Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. | Nat Commun | 2019 |
| 31101627 | Short regimen of rituximab plus lenalidomide in follicular lymphoma patients in need of first-line therapy. | Blood | 2019 |
| 31127856 | Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs. | FEBS Lett | 2019 |
| 30948485 | Immune marker changes and risk of multiple myeloma: a nested case-control study using repeated pre-diagnostic blood samples. | Haematologica | 2019 |
| 29343827 | Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. | Nat Commun | 2018 |
| 30018397 | Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts. | Sci Rep | 2018 |
| 29900613 | Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis. | Hum Mutat | 2018 |
| 30285560 | Chemotherapy-Free Initial Treatment of Advanced Indolent Lymphoma Has Durable Effect With Low Toxicity: Results From Two Nordic Lymphoma Group Trials With More Than 10 Years of Follow-Up. | J Clin Oncol | 2018 |
| 30442810 | Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. | Science | 2018 |
| 30304478 | MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP. | Nucleic Acids Res | 2018 |
| 29667176 | Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses. | Int J Cancer | 2018 |
| 29413322 | Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. | Structure | 2018 |
| 29281266 | Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. | Biochemistry | 2018 |
| 28067901 | Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. | Nat Med | 2017 |
| 28108506 | Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis. | Cancer Res | 2017 |
| 28447629 | Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. | Nature | 2017 |
| 28423595 | dUTPase inhibition augments replication defects of 5-Fluorouracil. | Oncotarget | 2017 |
| 28320322 | Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage. | BMC Genomics | 2017 |
| 28145708 | Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. | J Med Chem | 2017 |
| 28202064 | Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study. | Environ Health | 2017 |
| 29142246 | A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family. | Nat Commun | 2017 |
| 28508636 | Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. | J Med Chem | 2017 |
| 28687206 | Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines. | Bioorg Med Chem Lett | 2017 |
| 28862438 | Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. | J Med Chem | 2017 |
| 28655422 | Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems. | Bioorg Med Chem Lett | 2017 |
| 27899380 | Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. | Cancer Res | 2017 |
| 26791985 | Production, Purification, and Characterization of ¹âµN-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements. | Methods Enzymol | 2016 |
| 27827301 | Validation and development of MTH1 inhibitors for treatment of cancer. | Ann Oncol | 2016 |
| 27530327 | NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. | Cancer Res | 2016 |
| 26862114 | Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition. | Cancer Res | 2016 |
| 26771665 | Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. | J Med Chem | 2016 |