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Author Details

Lennart Mucke
Gladstone Institute of Neurological Disease, Gladstone Institutes
1982
168
97
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37591465Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.Neurobiol Dis2023
35476595TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model.Sci Transl Med2022
34686344Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony.Cell Rep2021
33833046Phenotypic Differences between the Alzheimer's Disease-Related hAPP-J20 Model and Heterozygous <i>Zbtb20</i> Knock-Out Mice.eNeuro2021
33632820Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies.Science2021
34755090Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models.iScience2021
34570177Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial.JAMA Neurol2021
32126198Tau Reduction Prevents Key Features of Autism in Mouse Models.Neuron2020
32831170Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.Elife2020
32848093A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.Sci Transl Med2020
32921309Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.Mol Neurodegener2020
30737131Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.Neuron2019
31101070Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease.Acta Neuropathol Commun2019
29100987Istradefylline reduces memory deficits in aging mice with amyloid pathology.Neurobiol Dis2018
30053424The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.Cell2018
29859869Neuronal levels and sequence of tau modulate the power of brain rhythms.Neurobiol Dis2018
30205056The mouse as a model for neuropsychiatric drug development.Curr Biol2018
30323343Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.Nat Immunol2018
30413620Klotho controls the brain-immune system interface in the choroid plexus.Proc Natl Acad Sci U S A2018
29551491Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.Neuron2018
28526038Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Mol Neurodegener2017
26931567Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.EMBO Rep2016
26589795Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.J Biol Chem2016
27764656Tau Phosphorylation-Much More than a Biomarker.Neuron2016
27696483Incidence and impact of subclinical epileptiform activity in Alzheimer's disease.Ann Neurol2016
27829687Network abnormalities and interneuron dysfunction in Alzheimer disease.Nat Rev Neurosci2016
25673831Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.J Neurosci2015
26615780DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.Nat Commun2015
26732627Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.Ann Clin Transl Neurol2015
26192747Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.Nat Neurosci2015
25880092Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.Cell Death Dis2015
25963821Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.J Cell Biol2015
25622143Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.Nat Neurosci2015
24813892Life extension factor klotho enhances cognition.Cell Rep2014
25551452Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.PLoS One2014
25261995Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Nat Med2014
25042160Tau reduction prevents disease in a mouse model of Dravet syndrome.Ann Neurol2014
23332171Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice.Neurobiol Aging2013
23835471Seizures and epileptiform activity in the early stages of Alzheimer disease.JAMA Neurol2013
23525040Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.Nat Neurosci2013
22424230Alzheimer mechanisms and therapeutic strategies.Cell2012
23029293Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.PLoS One2012
22762015Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.Cold Spring Harb Perspect Med2012
22869752Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.Proc Natl Acad Sci U S A2012
22541439Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.Cell2012
22272874Selective targeting of microglia by quantum dots.J Neuroinflammation2012
20967595Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling.Methods Mol Biol2011
22206005Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.PLoS One2011
21775587Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice.J Neurosci2011
21555069The many faces of tau.Neuron2011
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Collaborators

Eliezer Masliah
National Institute On Aging
Co-authored papers 45
Tony Wyss-Coray
Stanford University
Co-authored papers 21
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 12
Nino Devidze
Gladstone Institute of Neurological Disease
Co-authored papers 12
Jacob Raber
Oregon Health & Science University
Co-authored papers 10
Robert W Mahley
Gladstone Institute of Neurological Disease
Co-authored papers 8
Yungui Zhou
Gladstone Institutes
Co-authored papers 6
Bruce L Miller
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 6
Michael Gill
Co-authored papers 3
Steven Finkbeiner
J. David Gladstone Institutes
Co-authored papers 3
Michael E Ward
National Institute of Neurological, National Institutes of Health (NIH)
Co-authored papers 3
William W Seeley
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 3
Stuart A Lipton
The Scripps Research Institute, University of California
Co-authored papers 2
Reuben Thomas
Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes
Co-authored papers 2
Philip L De Jager
Columbia University Medical Center
Co-authored papers 2
Jae K Ryu
Gladstone Institutes
Co-authored papers 2
Sakura Minami
Dokkyo Medical University
Co-authored papers 2
Katerina Akassoglou
Gladstone Institute for Neurological Disease San Francisco
Co-authored papers 2
Tejal A Desai
University of California San Francisco
Co-authored papers 2
Joel H Kramer
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Giovanni Coppola
David Geffen School of Medicine, University of California los angeles
Co-authored papers 2
David A Bennett
Rush University Medical Center
Co-authored papers 2
Anke Meyer-Franke
Gladstone Institutes
Co-authored papers 1
Barbara Panning
University of California san francisco
Co-authored papers 1
Fred E Cohen
University of California san francisco
Co-authored papers 1
Vikaas S Sohal
University of California san francisco
Co-authored papers 1
Chao Wang
Gladstone Institutes
Co-authored papers 1
Mark von Zastrow
University of California san francisco
Co-authored papers 1
Mustafa Sahin
Harvard Medical School
Co-authored papers 1
Bruce R Conklin
Gladstone Institutes
Co-authored papers 1
Release 1.2