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Author Details

Jaume Pons
Pfizer Inc.
1994
64
38
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35027753Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication.Nat Med2022
34793719Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.Lancet Oncol2021
33514714Direct control of CAR T cells through small molecule-regulated antibodies.Nat Commun2021
33256806Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity.J Hematol Oncol2020
31257988Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα.MAbs2019
29078037The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2οa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies.Cardiovasc Ther2018
30133535ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile.PLoS One2018
29714014Epitope Mapping Using Yeast Display and Next Generation Sequencing.Methods Mol Biol2018
29227213Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies.MAbs2018
28151644Improved Lysosomal Trafficking Can Modulate the Potency of Antibody Drug Conjugates.Bioconjug Chem2017
26944918Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.Mol Cancer Ther2016
26481561Production of soluble and active microbial transglutaminase in Escherichia coli for site-specific antibody drug conjugation.Protein Sci2016
27582525RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models.Mol Cancer Ther2016
27857134Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire.Nat Commun2016
27129258Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.J Biol Chem2016
25284753Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing.J Mol Biol2015
26161543Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.PLoS One2015
26154005Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.Nat Biotechnol2015
25658443The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.MAbs2015
25643134Effect of attachment site on stability of cleavable antibody drug conjugates.Bioconjug Chem2015
24359082Mass spectrometric characterization of transglutaminase based site-specific antibody-drug conjugates.Bioconjug Chem2014
24981332Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.Cell Host Microbe2014
24830649Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes.MAbs2014
24651868High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity.PLoS One2014
23228330Impact of mutations on the allosteric conformational equilibrium.J Mol Biol2013
24223227Determining the binding affinity of therapeutic monoclonal antibodies towards their native unpurified antigens in human serum.PLoS One2013
23630353The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content.J Immunol2013
23416200Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin.J Mol Biol2013
23438745Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.Chem Biol2013
22197375Structural basis of C-terminal β-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease.J Mol Biol2012
23093611A method for integrative structure determination of protein-protein complexes.Bioinformatics2012
22543237Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair.J Mol Biol2012
22558410Exploring the dynamic range of the kinetic exclusion assay in characterizing antigen-antibody interactions.PLoS One2012
22609372Label-free epitope binning assays of monoclonal antibodies enable the identification of antigen heterogeneity.J Immunol Methods2012
22294692Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9.J Biol Chem2012
22403063Structure-based model of allostery predicts coupling between distant sites.Proc Natl Acad Sci U S A2012
22019884Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.J Pharmacol Exp Ther2012
2204548139-week toxicity and toxicokinetic study of ponezumab (PF-04360365) in cynomolgus monkeys with 12-week recovery period.J Alzheimers Dis2012
21168382Expanding the ProteOn XPR36 biosensor into a 36-ligand array expedites protein interaction analysis.Anal Biochem2011
22123975Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation.Proc Natl Acad Sci U S A2011
21825149Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems.Proc Natl Acad Sci U S A2011
21787786Synthetic antibodies designed on natural sequence landscapes.J Mol Biol2011
21690377Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.Proc Natl Acad Sci U S A2011
19111520Exploring blocking assays using Octet, ProteOn, and Biacore biosensors.Anal Biochem2009
19875695Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire.Proc Natl Acad Sci U S A2009
19369565Suppression of amyloid deposition leads to long-term reductions in Alzheimer's pathologies in Tg2576 mice.J Neurosci2009
18405656Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet.Anal Biochem2008
18776916CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat.Br J Pharmacol2008
18505735Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors.Protein Sci2008
18607758Deglycosylated anti-Abeta antibody dose-response effects on pathology and memory in APP transgenic mice.J Neuroimmune Pharmacol2008
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Collaborators

Pfizer Inc.
Co-authored papers 30
Pfizer Inc.
Co-authored papers 19
Pfizer Inc.
Co-authored papers 8
Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona
Co-authored papers 6
School of Chemistry & Pharmaceutical Sciences, Guangxi Normal University
Co-authored papers 5
University of California San Francisco
Co-authored papers 3
Rinat (Pfizer Inc.)
Co-authored papers 3
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 3
University of California san francisco
Co-authored papers 2
Stanford University
Co-authored papers 1
Co-authored papers 1
Pfizer Inc.
Co-authored papers 1
Institute for Biophysical Chemistry, Goethe-University
Co-authored papers 1
Co-authored papers 1
Stanford University
Co-authored papers 1
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 1
Co-authored papers 1
Center for Biomolecular and Cellular Structure, Institute for Basic Science (IBS)
Co-authored papers 1
Institute of Biomedical Sciences
Co-authored papers 1
Co-authored papers 1
Stanford University School of Medicine
Co-authored papers 1
University of California san francisco
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Department of Pediatrics Stanford University Stanford California USA.
Co-authored papers 1
Duke University
Co-authored papers 1
Stanford University
Co-authored papers 1
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 1
Co-authored papers 1
Lawrence Berkeley National Laboratory, University of California
Co-authored papers 1
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1