Author details

Full Name

Joshua A Bittker

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34130532	The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.	SLAS Discov	2021
32613204	Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.	Nat Cancer	2020
30964323	The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity.	Environ Health Perspect	2019
29249695	GDC-0879, a BRAF<sup>V600E</sup> Inhibitor, Protects Kidney Podocytes from Death.	Cell Chem Biol	2018
29878747	High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding.	ACS Chemical Biology	2018
30058798	High Throughput Screen Identifies Interferon Î³-Dependent Inhibitors of Toxoplasma gondii Growth.	ACS Infect Dis	2018
30089904	Genetic and transcriptional evolution alters cancer cell line drug response.	Nature	2018
28215073	Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.	ACS Infectious Diseases	2017
28388612	The Drug Repurposing Hub: a next-generation drug library and information resource.	Nat Med	2017
28340340	Selective Chemical Inhibition of PGC-1Î± Gluconeogenic Activity Ameliorates Type 2 Diabetes.	Cell	2017
28327978	A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay.	Gigascience	2017
29073062	Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.	Proc Natl Acad Sci U S A	2017
29195078	A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.	Cell	2017
27602946	Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.	Nature	2016
26656090	Correlating chemical sensitivity and basal gene expression reveals mechanism of action.	Nat Chem Biol	2016
26046436	Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.	Cell	2015
25477388	BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.	Nucleic Acids Res	2015
25556942	Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.	Chem Biol	2015
26482930	Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.	Cancer Discov	2015
25093074	Evolving BioAssay Ontology (BAO): modularization, integration and applications.	J Biomed Semantics	2014
24441647	An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines.	J Biomol Screen	2014
25024206	Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.	Proc Natl Acad Sci U S A	2014
23585218	An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.	J Comput Aided Mol Des	2013
24161946	Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.	Nat Chem Biol	2013
23993102	An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.	Cell	2013
23946849	ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.	Beilstein J Org Chem	2013
22117901	Utility-aware screening with clique-oriented prioritization.	J Chem Inf Model	2012
22693105	Automatically detecting workflows in PubChem.	J Biomol Screen	2012
22297109	Development of small-molecule probes that selectively kill cells induced to express mutant RAS.	Bioorg Med Chem Lett	2012
22497765	Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.	Bioorg Med Chem Lett	2012
23487248	High-Throughput RT-PCR for small-molecule screening assays.	Current protocols in chemical biology	2012
21685049	Enhancing the rate of scaffold discovery with diversity-oriented prioritization.	Bioinformatics	2011
21802942	Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.	Bioorg Med Chem Lett	2011
22018462	Identification of small-molecule inhibitors of Trypansoma cruzi replication.	Bioorg Med Chem Lett	2011
20547534	An economic framework to prioritize confirmatory tests after a high-throughput screen.	J Biomol Screen	2010
20696901	Small-molecule inducers of insulin expression in pancreatic alpha-cells.	Proc Natl Acad Sci U S A	2010
16039523	Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection.		2005
15118093	Directed evolution of protein enzymes using nonhomologous random recombination.	Proceedings of the National Academy of Sciences of the United States of America	2004
12023118	Recent advances in the in vitro evolution of nucleic acids.	Current Opinion in Chemical Biology	2002
12219078	Nucleic acid evolution and minimization by nonhomologous random recombination.	Nature Biotechnology	2002