Author details

Full Name

Lin S Chen

Affiliation

ORCID

Career Start Year

2011

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36668670	Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations.	PLoS Genet	2023
36510025	DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits.	Nat Genet	2023
36310177	Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology.	Nature Communications	2022
33647928	CCmed: cross-condition mediation analysis for identifying replicable trans-associations mediated by cis-gene expression.		2021
33834509	A robust two-sample transcriptome-wide Mendelian randomization method integrating GWAS with multi-tissue eQTL summary statistics.	Genetic Epidemiology	2021
34038222	Erratum: "Rare, protein-altering variants in <i>AS3MT</i> and arsenic metabolism efficiency: a multi-population association study".	Environ Health Perspect	2021
32912334	Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits.		2020
32118202	IGREX for quantifying the impact of genetically regulated expression on phenotypes.	NAR Genomics and Bioinformatics	2020
31923397	Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.	Cell	2020
32913074	Determinants of telomere length across human tissues.	Science	2020
31227599	Insights into Impact of DNA Copy Number Alteration and Methylation on the Proteogenomic Landscape of Human Ovarian Cancer via a Multi-omics Integrative Analysis.	Molecular and Cellular Proteomics	2019
31675502	Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.	Cell	2019
30536049	The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans.	Hum Genet	2019
29939200	Using multivariate mixed-effects selection models for analyzing batch-processed proteomics data with non-ignorable missingness.	Biostatistics	2019
31281117	Integrative Proteo-genomic Analysis to Construct CNA-protein Regulatory Map in Breast and Ovarian Tumors.	Mol Cell Proteomics	2019
29151059	Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal.	J Med Genet	2018
29898891	Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer.	Cancer Epidemiol Biomarkers Prev	2018
29476079	Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms.	Nat Commun	2018
29430690	A meta-analysis approach with filtering for identifying gene-level gene-environment interactions.	Genet Epidemiol	2018
29743963	A MIXED-EFFECTS MODEL FOR INCOMPLETE DATA FROM LABELING-BASED QUANTITATIVE PROTEOMICS EXPERIMENTS.	Annals of Applied Statistics	2017
28503721	Limited influence of germline genetic variation on all-cause mortality in women with early onset breast cancer: evidence from gene-based tests, single-marker regression, and whole-genome prediction.	Breast Cancer Res Treat	2017
28630379	The association between telomere length and mortality in Bangladesh.	Aging (Albany NY)	2017
29021290	Identifying -mediators for -eQTLs across many human tissues using genomic mediation analysis.	Genome Research	2017
28171663	Genome-wide association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer.	Hum Mol Genet	2016
27040689	Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx.	Am J Hum Genet	2016
26496228	A unified set-based test with adaptive filtering for gene-environment interaction analyses.	Biometrics	2016
25781581	Breast cancer risk after full-term pregnancies among African women from Nigeria, Cameroon, and Uganda.	Cancer	2015
25325195	Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh.	Environ Health Perspect	2015
24471933	A penalized EM algorithm incorporating missing data mechanism for Gaussian parameter estimation.	Biometrics	2014
25474530	Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians.	PLoS Genet	2014
23468125	Marbled inflation from population structure in gene-based association studies with rare variants.	Genetic Epidemiology	2013
23159251	An exponential combination procedure for set-based association tests in sequencing studies.	Am J Hum Genet	2012
22565837	Using eQTLs to reconstruct gene regulatory networks.	Methods in Molecular Biology	2012
23997374	A regularized Hotelling's test for pathway analysis in proteomic studies.	Journal of the American Statistical Association	2011