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Author Details

Joseph D O'Connell
Department of Pharmaceutical Chemistry, University of California-San Francisco
2002
18
15
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37354015Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.Protein Sci2023
26470919Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.J Mol Biol2015
24613931Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.Proc Natl Acad Sci U S A2014
23710599Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.J Med Chem2013
24173033Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter.Proc Natl Acad Sci U S A2013
20534468Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems.Proc Natl Acad Sci U S A2010
20855585Structural context shapes the aquaporin selectivity filter.Proc Natl Acad Sci U S A2010
19061901Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.J Mol Biol2009
19360018A general protocol for the crystallization of membrane proteins for X-ray structural investigation.Nat Protoc2009
18500352Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.Nat Struct Mol Biol2008
17190799Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A.Proc Natl Acad Sci U S A2007
15361618Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A.Science2004
12575934Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase.Structure2003
12948772Glycerol facilitator GlpF and the associated aquaporin family of channels.Curr Opin Struct Biol2003
14691544Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.PLoS Biol2003
11964478Control of the selectivity of the aquaporin water channel family by global orientational tuning.Science2002
12429097Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway.Structure2002
29973827Encoding Selectivity of a Transmembrane Channel.ScientificWorldJournal2002
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Collaborators

University of California San Francisco
Co-authored papers 17
University of California San Francisco
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University of California San Francisco
Co-authored papers 4
University of California berkeley
Co-authored papers 4
University of California san francisco
Co-authored papers 3
Center for the Structure of Membrane Proteins, University of California san francisco
Co-authored papers 2
University of Oklahoma Health Sciences Center
Co-authored papers 2
University of California San Francisco
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Albert Einstein College of Medicine
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University of California San Francisco
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Pfizer Inc.
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Betty Irene Moore School of Nursing at the University of California davis
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Northwestern University Feinberg School of Medicine
Co-authored papers 1
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 1
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 1
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
University of California san francisco
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Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
Northwestern University
Co-authored papers 1
Vagelos College of Physicians and Surgeons, Columbia University
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Department of Pharmaceutical Chemistry, University of California san francisco
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Icahn School of Medicine at Mount Sinai
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