Author details

Full Name

Sailaja Gangadhara

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37553348	Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques.	Nat Commun	2023
35357886	A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection.	Sci Immunol	2022
35503780	A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.	PLoS Pathog	2022
35935987	V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A*01 negative Rhesus Macaques.	Front Immunol	2022
35867800	A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.	Sci Immunol	2022
33441437	Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses.	Journal of Immunology	2021
34234789	Oral Vaccination Approaches for Anti-SHIV Immunity.	Frontiers in Immunology	2021
34117252	SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.	Nat Commun	2021
33631118	A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.	Immunity	2021
33556148	The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.	PLoS Pathog	2021
32393800	T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.	Nat Med	2020
31341049	Human Immunodeficiency Virus C.1086 Envelope gp140 Protein Boosts following DNA/Modified Vaccinia Virus Ankara Vaccination Fail To Enhance Heterologous Anti-V1V2 Antibody Response and Protection against Clade C Simian-Human Immunodeficiency Virus Challenge.	J Virol	2019
31748228	Strong T<sub>H</sub>1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.	Sci Transl Med	2019
30541829	Novel Modified Vaccinia Virus Ankara Vector Expressing Anti-apoptotic Gene Delays Apoptosis and Enhances Humoral Responses.	Journal of Virology	2019
30651354	Clade C HIV-1 Envelope Vaccination Regimens Differ in Their Ability To Elicit Antibodies with Moderate Neutralization Breadth against Genetically Diverse Tier 2 HIV-1 Envelope Variants.	J Virol	2019
29491157	Intragastric Administration of Lactobacillus plantarum and 2,2'-Dithiodipyridine-Inactivated Simian Immunodeficiency Virus (SIV) Does Not Protect Indian Rhesus Macaques from Intrarectal SIV Challenge or Reduce Virus Replication after Transmission.	Journal of Virology	2018
29257056	Vaccination with Combination DNA and Virus-Like Particles Enhances Humoral and Cellular Immune Responses upon Boost with Recombinant Modified Vaccinia Virus Ankara Expressing Human Immunodeficiency Virus Envelope Proteins.	Vaccines	2017
27683750	High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5Î±-Restrictive Macaques.	Journal of Immunology	2016
27006959	Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine.	Open Forum Infectious Diseases	2016
27481845	Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells.	Journal of Immunology	2016
27466414	Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.	J Virol	2016
26116502	Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques.	Journal of Immunology	2015
25653428	CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.	Journal of Virology	2015
24920805	CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus SIV239 vaccine enhances SIV-specific humoral and cellular immunity and improves protection against a heterologous SIVE660 mucosal challenge.	Journal of Virology	2014
24574408	Local control of repeated-dose rectal challenges in DNA/MVA-vaccinated macaques protected against a first series of simian immunodeficiency virus challenges.	Journal of Virology	2014
22973033	Deletion of specific immune-modulatory genes from modified vaccinia virus Ankara-based HIV vaccines engenders improved immunogenicity in rhesus macaques.	J Virol	2012
19421328	Expanding the repertoire of Modified Vaccinia Ankara-based vaccine vectors via genetic complementation strategies.	PLoS ONE	2009
17108046	Incorporation of glycosylphosphatidylinositol-anchored granulocyte- macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles.	Journal of Virology	2007
17276476	Human immunodeficiency virus-like particles activate multiple types of immune cells.	Virology	2007
17320250	Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins.	Vaccine	2007
16563456	Augmenting the immunogenicity of DNA vaccines: role of plasmid-encoded Flt-3 ligand, as a molecular adjuvant in genetic vaccination.	Virology	2006
12594275	Long-term maintenance of gp120-specific immune responses by genetic vaccination with the HIV-1 envelope genes linked to the gene encoding Flt-3 ligand.	Journal of Immunology	2003
14512535	Enhancement of gp120-specific immune responses by genetic vaccination with the human immunodeficiency virus type 1 envelope gene fused to the gene coding for soluble CTLA4.	Journal of Virology	2003
12457287	Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector-specific immune response.	Gene Therapy	2002
11190505	Evaluating the dynein heavy chain gene family in Tetrahymena.	Methods in Molecular Biology	2001
10930680	Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response.	Vaccine	2000
10423140	Many different papillomaviruses have low transcriptional activity in spite of strong epithelial specific enhancers.	Journal of General Virology	1999
8781503	Azidothymidine induces apoptosis in mouse myeloma cell line Sp2/0.	Biochemical Pharmacology	1996