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Author Details

Robert L Wiseman
The Scripps Research Institute
1972
109
43
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36630963Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis.Cell Chem Biol2023
37619563Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.Cell Chem Biol2023
37550454DELE1 oligomerization promotes integrated stress response activation.Nat Struct Mol Biol2023
37922906Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells.Cell Chem Biol2023
37155889S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.Proc Natl Acad Sci U S A2023
37215033Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.bioRxiv2023
37306086PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid.EMBO J2023
37433773Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity.Nat Commun2023
37398499Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.bioRxiv2023
36786771Quantifying organellar ultrastructure in cryo-electron tomography using a surface morphometrics pipeline.J Cell Biol2023
36712115Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators.bioRxiv2023
36535406Mitochondria and Endoplasmic Reticulum Stress in Retinal Organoids from Patients with Vision Loss.Am J Pathol2023
35105890Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.Nat Commun2022
35477478Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA<sub>A</sub> receptors.Cell Biosci2022
35626697ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors.Cells2022
35452616Reshaping endoplasmic reticulum quality control through the unfolded protein response.Mol Cell2022
36170373Circadian disruption enhances HSF1 signaling and tumorigenesis in <i>Kras</i>-driven lung cancer.Sci Adv2022
36053251Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses.J Exp Med2022
35191945Stress-responsive regulation of extracellular proteostasis.J Cell Biol2022
35143841Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.J Biol Chem2022
34046940The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3-4, 2021.FASEB J2021
33599742Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion.Blood Adv2021
33545358Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.Mol Ther2021
34797633Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2.ACS Chem Biol2021
34561305ATF6 is essential for human cone photoreceptor development.Proc Natl Acad Sci U S A2021
34050165Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.Nat Commun2021
32490208Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.Sci Adv2020
33096892Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3.Antioxidants (Basel)2020
32690944Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.Nat Chem Biol2020
32887796Small molecule strategies to harness the unfolded protein response: where do we go from here?J Biol Chem2020
32735824Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease.Stem Cell Reports2020
32620695Correction: Thioredoxin-related protein 32 is an arsenite-regulated thiol reductase of the proteasome 19 S particle.J Biol Chem2020
32412081Starting at the beginning: endoplasmic reticulum proteostasis and systemic amyloid disease.Biochem J2020
30643122Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.Nat Commun2019
31327635Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.Mol Cell2019
31201389Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.Nat Cell Biol2019
30975687Lining up for quality control: linear ubiquitin and proteotoxicity.EMBO J2019
30821953Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing.ACS Chem Biol2019
31078432Proteostasis and Beyond: ATF6 in Ischemic Disease.Trends Mol Med2019
31105062Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein.Cell Chem Biol2019
30675021PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress.Sci Rep2019
29539413The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress.Cell Rep2018
30072094Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases.Int Rev Cell Mol Biol2018
30032658A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics.Amyloid2018
30084354Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.Elife2018
29521097Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.Biochemistry2018
29440509The unfolded protein response regulator ATF6 promotes mesodermal differentiation.Sci Signal2018
28655754The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.EMBO J2017
29097521Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.Science2017
28647092Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy.Trends Cell Biol2017
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Collaborators

Gabriel C Lander
The Scripps Research Institute
Co-authored papers 9
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 4
David Ron
Cambridge Institute for Medical Research, University of Cambridge
Co-authored papers 4
Cristina Puchades
University of California San Francisco (UCSF) School of Medicine
Co-authored papers 4
Cole M Haynes
university of massachusetts amherst Chan Medical School
Co-authored papers 4
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
John R Yates
TheScripps Research Institute
Co-authored papers 2
King-Tung Chin
The University of Hong Kong
Co-authored papers 2
Assen Roguev
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 2
Alan Keith Dunker
Center for Computational Biology, Indiana University School of Medicine
Co-authored papers 2
Ariel Stanhill
Open University of Israel
Co-authored papers 2
Thomas A Neubert
Neuroscience Institute, NYU Grossman School of Medicine
Co-authored papers 2
Chong-Feng Xu
Biogen Inc.
Co-authored papers 2
Anne Dell
Co-authored papers 1
JoAnn Trejo
University of California
Co-authored papers 1
Chunlei Wu
The Scripps Research Institute
Co-authored papers 1
Martin Friedlander
the Scripps Research Institute
Co-authored papers 1
Peter X Shaw
Shiley Eye Institute, University of California San Diego
Co-authored papers 1
Joseph Carroll
Medical College of Wisconsin Eye Institute
Co-authored papers 1
Rub??n Vicente
Universitat Pompeu Fabra
Co-authored papers 1
Andrew I Su
The Scripps Research Institute
Co-authored papers 1
Patrick R Griffin
The Scripps Research Institute
Co-authored papers 1
Peter Walter
University of California san francisco
Co-authored papers 1
Catherine E Costello
Center for Biomedical Mass Spectrometry, Boston University
Co-authored papers 1
Stuart M Haslam
Co-authored papers 1
Gustavo Mostoslavsky
Co-authored papers 1
Colleen Fearns
Co-authored papers 1
Michel Michaelides
Institute of Ophthalmology, University College London
Co-authored papers 1
James Shorter
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 1
Stefano Monti
Co-authored papers 1
Release 1.2