Skip to Main Content

Author Details

Lawrence J Lesko
Department of Pharmaceutics, University of Florida
1979
217
56
PMIDPaper TitleJournal TitlePublished Year
34328221Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations.J Clin Pharmacol2022
36611850Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin.Cells2022
35191192Application of a patient-centered reverse translational systems-based approach to understand mechanisms of an adverse drug reaction of immune checkpoint inhibitors.Clin Transl Sci2022
35014203A case study of a patient-centered reverse translational systems-based approach to understand adverse event profiles in drug development.Clin Transl Sci2022
35143713Advancing drug safety science by integrating molecular knowledge with post-marketing adverse event reports.CPT Pharmacometrics Syst Pharmacol2022
34524700Dosing Regimen Prediction and Confirmation With Rivaroxaban for Thromboprophylaxis in Children After the Fontan Procedure: Insights From the Phase III UNIVERSE Study.J Clin Pharmacol2022
33035445Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy.Annu Rev Pharmacol Toxicol2021
33892143Towards population-specific pharmacogenomics in the era of next-generation sequencing.Drug Discov Today2021
34404115Perspective on model-informed drug development.CPT Pharmacometrics Syst Pharmacol2021
34284600Tabula Rasa HealthCare company profile: involvement in pharmacogenomic and personalized medicine research.Pharmacogenomics2021
33449439Physiologically-based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate.CPT Pharmacometrics Syst Pharmacol2021
32329770Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function.JAMA Netw Open2020
33025766A Review on Drug-Induced Nephrotoxicity: Pathophysiological Mechanisms, Drug Classes, Clinical Management, and Recent Advances in Mathematical Modeling and Simulation Approaches.Clin Pharmacol Drug Dev2020
33235392FDALabel for drug repurposing studies and beyond.Nat Biotechnol2020
32765265Quantitative Systems Pharmacology Model-Based Predictions of Clinical Endpoints to Optimize Warfarin and Rivaroxaban Anti-Thrombosis Therapy.Front Pharmacol2020
32335903Semi-mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities.Br J Pharmacol2020
32335844A clinical population pharmacokinetic/pharmacodynamic model for BIIB059, a monoclonal antibody for the treatment of systemic and cutaneous lupus erythematosus.J Pharmacokinet Pharmacodyn2020
30716169Is Bioequivalence Established Based on the Reference-Scaled Average Bioequivalence Approach Relevant to Chronic Administration of Phenytoin? Perspectives Based on Population Pharmacokinetic Modeling and Simulations.J Clin Pharmacol2019
31087554Evaluating the Clinical Impact of Formulation Variability: A Metoprolol Extended-Release Case Study.J Clin Pharmacol2019
31087553Physiologically Based Pharmacokinetic Modeling to Evaluate Formulation Factors Influencing Bioequivalence of Metoprolol Extended-Release Products.J Clin Pharmacol2019
31087551An Integrated Bioinformatics and Quantitative Modeling Approach to Investigate Potential Claims of Oral Generic Drug Product Bioinequivalence: Introduction.J Clin Pharmacol2019
28858397Model-Based Approach to Predict Adherence to Protocol During Antiobesity Trials.J Clin Pharmacol2018
29935299Past, Present, and Future of Bioequivalence: Improving Assessment and Extrapolation of Therapeutic Equivalence for Oral Drug Products.J Pharm Sci2018
30255663Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities.CPT Pharmacometrics Syst Pharmacol2018
30043511A Semi-Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy.CPT Pharmacometrics Syst Pharmacol2018
30260082Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate.CPT Pharmacometrics Syst Pharmacol2018
30377889A pre-clinical quantitative model predicts the pharmacokinetics/pharmacodynamics of an anti-BDCA2 monoclonal antibody in humans.J Pharmacokinet Pharmacodyn2018
29485684Regulatory Perspectives in Pharmacometric Models of Osteoporosis.J Clin Pharmacol2018
29052220Efficacy From Strange Sources.Clin Pharmacol Ther2018
29197167To Take or Not to Take With Meals? Unraveling Issues Related to Food Effects Labeling for Oral Antineoplastic Drugs.Clin Pharmacol Drug Dev2018
27557470Identifying clinically relevant sources of variability: The clopidogrel challenge.Clin Pharmacol Ther2017
28162967Development and validation of a LC-MS/MS assay for quantification of cisplatin in rat plasma and urine.J Chromatogr B Analyt Technol Biomed Life Sci2017
28182269Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.Clin Pharmacol Ther2017
28466392Preemptive Panel-Based Pharmacogenetic Testing: The Time is Now.Pharm Res2017
28585859Evaluation of the Potential for Drug Interactions With Patiromer in Healthy Volunteers.J Cardiovasc Pharmacol Ther2017
27040602How Informative Are Drug-Drug Interactions of Gene-Drug Interactions?J Clin Pharmacol2016
26288087Osteonecrosis of the Jaw in the United States Food and Drug Administration's Adverse Event Reporting System (FAERS).J Bone Miner Res2016
26524713Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults.Eur J Pharm Sci2016
26470760Are We Getting the Best Return on Investment From Clinical Drug-Drug Interaction Studies?J Clin Pharmacol2016
27647667Quantitative Systems Pharmacology Model to Predict the Effects of Commonly Used Anticoagulants on the Human Coagulation Network.CPT Pharmacometrics Syst Pharmacol2016
27197625Anticoagulants: What is new and what is the standard?Clin Pharmacol Ther2016
27287422Improving drug safety with a systems pharmacology approach.Eur J Pharm Sci2016
27251780Systems pharmacology to predict drug safety in drug development.Eur J Pharm Sci2016
25559342Clinical pharmacokinetics and pharmacodynamics of clopidogrel.Clin Pharmacokinet2015
27548289Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models.CPT Pharmacometrics Syst Pharmacol2015
26186657Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy.Ther Drug Monit2015
26225258Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making.CPT Pharmacometrics Syst Pharmacol2015
24286486Clinical implementation of genetic testing in medicine: a US regulatory science perspective.Br J Clin Pharmacol2014
25271939Model-based assessment of dosing strategies in children for monoclonal antibodies exhibiting target-mediated drug disposition.CPT Pharmacometrics Syst Pharmacol2014
25141898Pharmacogenetic research in partnership with American Indian and Alaska Native communities.Pharmacogenomics2014
  • 1 - 50 of 217

Recommended Authors

Chulalongkorn University
Career Start Year 2013
Number of shared co-authors 0
Amunix Pharmaceuticals
Career Start Year 2006
Number of shared co-authors 2
Georgetown University Medical Center
Career Start Year 2006
Number of shared co-authors 28
Unit for Pharmacokinetics and Drug Metabolism, University of Gothenburg
Career Start Year 2005
Number of shared co-authors 0
Collegeville
Career Start Year 2004
Number of shared co-authors 0
Clinical Development
Career Start Year 2003
Number of shared co-authors 0
Schulich School of Medicine and Dentistry, Western University
Career Start Year 2003
Number of shared co-authors 3
Genentech Inc.
Career Start Year 2003
Number of shared co-authors 2
Harbin Medical University
Career Start Year 2002
Number of shared co-authors 2
University of Pittsburgh School of Pharmacy
Career Start Year 2002
Number of shared co-authors 0
Oncology R&D
Career Start Year 1998
Number of shared co-authors 0
Clinical Development
Career Start Year 1998
Number of shared co-authors 0
Washington State University
Career Start Year 1996
Number of shared co-authors 0
University of Pennsylvania Perelman School of Medicine
Career Start Year 1996
Number of shared co-authors 17
and of Biochemistry and Pharmacy, University of Tuebingen
Career Start Year 1996
Number of shared co-authors 22
University of Pennsylvania.
Career Start Year 1995
Number of shared co-authors 0
Ohio State University
Career Start Year 1994
Number of shared co-authors 9
University of California San Francisco
Career Start Year 1993
Number of shared co-authors 16
University of Louisville
Career Start Year 1991
Number of shared co-authors 0
Health Services and Systems Research, Duke-NUS Medical School
Career Start Year 1990
Number of shared co-authors 5
Center for Drug Evaluation and Research
Career Start Year 1989
Number of shared co-authors 0
Department of Pharmaceutical Sciences, Utrecht University
Career Start Year 1987
Number of shared co-authors 3
Schulich School of Medicine and Dentistry, University of Western Ontario
Career Start Year 1986
Number of shared co-authors 4
University of Kansas Medical Center
Career Start Year 1985
Number of shared co-authors 0
UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill
Career Start Year 1984
Number of shared co-authors 4
University of California San Francisco
Career Start Year 1978
Number of shared co-authors 20
Vanderbilt University
Career Start Year 1974
Number of shared co-authors 1
Center for Pharmacoepidemiology and Treatment Science, Rutgers University
Career Start Year 1970
Number of shared co-authors 2
Perelman School of Medicine, University of Pennsylvania
Career Start Year 1968
Number of shared co-authors 1
1 Vanderbilt University Medical Center
Career Start Year 1958
Number of shared co-authors 4

Collaborators

Co-authored papers 5
Co-authored papers 5
University of Maryland School of Medicine
Co-authored papers 4
National Center for Toxicological Research
Co-authored papers 3
Department of Pharmacotherapy and Translational Research, University of Florida
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Center for Pharmacogenomics and Precision Medicine, University of Florida
Co-authored papers 2
Mayo Clinic
Co-authored papers 2
Vanderbilt University Medical Center
Co-authored papers 2
Departments of Pharmaceutical Sciences.
Co-authored papers 2
Stanford University
Co-authored papers 2
Epstein Health LLC
Co-authored papers 2
University of Maryland
Co-authored papers 1
Center for Computational and Integrative Biology, Massachusetts General Hospital
Co-authored papers 1
University of Maryland School of Medicine
Co-authored papers 1
Vanderbilt University Medical Center
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
Co-authored papers 1
University of Maryland
Co-authored papers 1
University of Maryland School of Medicine
Co-authored papers 1
Co-authored papers 1
The Children's Hospital of Philadelphia, University of Pennsylvania
Co-authored papers 1
Co-authored papers 1
Northwestern University Feinberg School of Medicine
Co-authored papers 1
BC Children's Hospital Research Institute
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Greenebaum Comprehensive Cancer Center, University of Maryland
Co-authored papers 1
Harvard Medical School
Co-authored papers 1