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Author Details

Alex Murison
Princess Margaret Cancer Centre, University Health Network
2012
35
23
PMIDPaper TitleJournal TitlePublished Year
36720973KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.Leukemia2023
37479893Single-cell chromatin accessibility profiling of acute myeloid leukemia reveals heterogeneous lineage composition upon therapy-resistance.Commun Biol2023
37600767The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population.Front Immunol2023
37020039Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer.Oncogene2023
37034724Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing.bioRxiv2023
35263585Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.Cell Rep2022
36131042A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.Leukemia2022
33242413The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization.Cell Stem Cell2021
33594052Biological and therapeutic implications of a unique subtype of NPM1 mutated AML.Nat Commun2021
34103329Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia.Cancer Discov2021
34244384Mapping the cellular origin and early evolution of leukemia in Down syndrome.Science2021
33958784A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness.Nat Immunol2021
34343492TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate.Cell Stem Cell2021
32546577Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.Cancer Discov2020
31974375Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.Nat Commun2020
30352278Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.Exp Hematol2019
31249064High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.Genome Res2019
31591588Genome-wide germline correlates of the epigenetic landscape of prostate cancer.Nat Med2019
30926792Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.Nat Commun2019
30889379The Proteogenomic Landscape of Curable Prostate Cancer.Cancer Cell2019
29342133A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.Nature2018
29769714Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.Nature2018
29650590Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network.Development2018
28034915Early-life antibiotic treatment enhances the pathogenicity of CD4<sup>+</sup> T cells during intestinal inflammation.J Leukoc Biol2017
28783165TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.Nat Genet2017
28550183The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma.Haematologica2017
28068672Genomic hallmarks of localized, non-indolent prostate cancer.Nature2017
27235425The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.Clin Cancer Res2016
25428216Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations.Blood2015
26626085MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.Cancer Cell2015
26282654Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.J Clin Oncol2015
25904160APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma.Nat Commun2015
24480973Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma.Leukemia2014
24923560A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.PLoS One2014
23216157Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes.Inhal Toxicol2012
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Collaborators

Mathieu Lupien
Princess Margaret Cancer Research Centre
Co-authored papers 19
John E Dick
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 15
Michelle Chan-Seng-Yue
Princess Margaret Cancer Centre
Co-authored papers 6
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 6
Daniel D De Carvalho
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 6
Seyed Ali Madani Tonekaboni
Princess Margaret Cancer Research Centre
Co-authored papers 5
Vincent Huang
Ontario Institute for Cancer Research
Co-authored papers 5
Theodorus H van der Kwast
University Health Network, University of Toronto
Co-authored papers 5
Paul C Boutros
University of California los angeles
Co-authored papers 5
Robert G Bristow
University of Toronto
Co-authored papers 5
Michael Fraser
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Ken J Kron
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Yu-Jia Shiah
Ontario Institute for Cancer Research
Co-authored papers 4
Tiago da Silva Medina
International Research Center, A.C.Camargo Cancer Center
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Julie Livingstone
University of California los angeles
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Stanley Zhou
Princess Margaret Cancer Research Centre
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Takafumi N Yamaguchi
University of California los angeles
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Shadrielle Melijah G Espiritu
Ontario Institute for Cancer Research
Co-authored papers 3
Musaddeque Ahmed
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Michael D Taylor
The Hospital for Sick Children
Co-authored papers 3
Dalia Barsyte-Lovejoy
University of Toronto, College St
Co-authored papers 3
Lawrence E Heisler
Ontario Institute for Cancer Research
Co-authored papers 3
Bernard T??tu
Centre de Recherche du CHU de Quebec-Universite Laval (axe Oncologie)
Co-authored papers 3
Housheng Hansen He
Princess Margaret Cancer Center, University Health Network, University of Toronto
Co-authored papers 3
Jeremy Johns
Rutgers Robert Wood Johnson Medical School
Co-authored papers 2
Cindy Q Yao
Ontario Institute for Cancer Research
Co-authored papers 2
Marco Gallo
Co-authored papers 2
H??l??ne Hovington
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