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Author Details

R Scott Lokey
University of California Santa Cruz
2000
80
33
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37815526High-Content Image-Based Screening and Deep Learning for the Detection of Anti-Inflammatory Drug Leads.Chembiochem2024
36932083Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides.Nat Commun2023
37426286DNA-Compatible Conditions for the Formation of <i>N</i>-Methyl Peptide Bonds.ACS Omega2023
35275623A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding.J Med Chem2022
36480613Getting bifunctional molecules into cells.Science2022
36467910Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity.ACS Omega2022
36449542High-throughput functional annotation of natural products by integrated activity profiling.Proc Natl Acad Sci U S A2022
33381960Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability.J Am Chem Soc2021
33875435Developing Cyclic Peptomers as Broad-Spectrum Type III Secretion System Inhibitors in Gram-Negative Bacteria.Antimicrob Agents Chemother2021
34881891Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity.J Med Chem2021
34672629Cyclosporin A: Conformational Complexity and Chameleonicity.J Chem Inf Model2021
34251165Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives.ACS Chem Biol2021
32789999Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity.Angew Chem Int Ed Engl2020
33139554Evidence for aggregation-independent, PrP<sup>C</sup>-mediated Aβ cellular internalization.Proc Natl Acad Sci U S A2020
32939229Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.ACS Med Chem Lett2020
32902550Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability.Org Biomol Chem2020
30657701Macrophage Cytological Profiling and Anti-Inflammatory Drug Discovery.Assay Drug Dev Technol2019
31042375Conformation and Permeability: Cyclic Hexapeptide Diastereomers.J Chem Inf Model2019
29459147CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry.Bioorg Med Chem2018
34158674The Bioactive Lipid (S)-Sebastenoic Acid Impacts Motility and Dispersion in <i>Vibrio cholerae</i>.Can J Chem2018
30025185Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source.Angew Chem Int Ed Engl2018
30395703Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.J Med Chem2018
29744489Using <sup>1</sup>H and <sup>13</sup>C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach.Phys Chem Chem Phys2018
28059508Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.J Med Chem2017
28461474Retrospective analysis of natural products provides insights for future discovery trends.Proc Natl Acad Sci U S A2017
28159754Reliance of <i>Wolbachia</i> on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of <i>Drosophila</i> Cells.Genetics2017
28128950Naphthablins B and C, Meroterpenoids Identified from the Marine Sediment-Derived Streptomyces sp. CP26-58 Using HeLa Cell-Based Cytological Profiling.J Nat Prod2017
29045152Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators.J Med Chem2017
28652236Synthetic Cyclic Peptomers as Type III Secretion System Inhibitors.Antimicrob Agents Chemother2017
28570865Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets.Curr Opin Chem Biol2017
28710331Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high.Proc Natl Acad Sci U S A2017
26845289A Strategy for Direct Chemical Activation of the Retinoblastoma Protein.ACS Chem Biol2016
27587783Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae.Cold Spring Harb Protoc2016
27587777A High-Throughput Yeast Halo Assay for Bioactive Compounds.Cold Spring Harb Protoc2016
27690434Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.J Med Chem2016
27563399Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.ACS Med Chem Lett2016
25517352Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.J Am Chem Soc2015
26292657Phenotype-Guided Natural Products Discovery Using Cytological Profiling.J Nat Prod2015
26308180Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.J Med Chem2015
26046483Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides.Org Lett2015
26067057Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.Future Med Chem2015
25950816Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.J Med Chem2015
25699470Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides.J Nat Prod2015
25412436Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides.Org Lett2014
23578022Designing molecules to cross biological membranes.Curr Top Med Chem2013
24063667Selective, on-resin N-methylation of peptide N-trifluoroacetamides.Org Lett2013
24056581Large-scale cytological profiling for functional analysis of bioactive compounds.Mol Biosyst2013
23771823A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes.J Biomol Screen2013
23438757"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening.Chem Biol2013
23578026Form and function in cyclic peptide natural products: a pharmacokinetic perspective.Curr Top Med Chem2013
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Collaborators

Nadine C Gassner
UC Santa Cruz Genomics Institute, University of California
Co-authored papers 10
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 10
Roger G Linington
Simon Fraser University
Co-authored papers 9
Joshua M Stuart
University of California at Santa Cruz
Co-authored papers 4
William H Gerwick
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 2
Ronald W Davis
Stanford University
Co-authored papers 2
Fitnat H Yildiz
Co-authored papers 2
Laura Kapitzky
QB3 Institute, University of California san francisco
Co-authored papers 2
Joanne N Engel
University of California san francisco
Co-authored papers 1
Jessica Sherry
University of California San Francisco
Co-authored papers 1
David P Toczyski
University of California San Francisco
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Theresa J Berens
University of California san francisco
Co-authored papers 1
Kenji L Kurita
Small Molecule Pharmaceutical Sciences, Genentech Inc.
Co-authored papers 1
Jack Taunton
University of California san francisco
Co-authored papers 1
Stephen J Elledge
Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Arthur Wuster
Genentech Inc.
Co-authored papers 1
Madan Mohan Babu
St. Jude Children's Research Hospital
Co-authored papers 1
Julie Wu
Co-authored papers 1
Chakrapani Kalyanaraman
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 1
Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 1
Chunshui Zhou
Harbin Medical University
Co-authored papers 1
Release 1.2