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Author Details

Jeffrey D Rudolf
University of Florida
2013
50
20
Gloria M Sheynkman (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36937101First <i>trans</i>-eunicellane terpene synthase in bacteria.Chem2023
34718710The Natural Products Atlas 2.0: a database of microbially-derived natural products.Nucleic Acids Res2022
35467071The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease.Chembiochem2022
36698006Structure-guided product determination of the bacterial type II diterpene synthase Tpn2.Commun Chem2022
36416740Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase.J Am Chem Soc2022
36278314Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis.Chembiochem2022
35961013A roadmap for the functional annotation of protein families: a community perspective.Database (Oxford)2022
36321628Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability.Org Biomol Chem2022
33169126Bacterial terpenome.Nat Prod Rep2021
33780586Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid.Angew Chem Int Ed Engl2021
34378291Mechanistic Insights into the Formation of the 6,10-Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4.Angew Chem Int Ed Engl2021
34796043Bacterial diterpene synthases prenylate small molecules.ACS Catal2021
32792393Divergent synthesis of complex diterpenes through a hybrid oxidative approach.Science2020
31650156Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.Nat Prod Rep2020
30735041Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.J Am Chem Soc2019
31244223Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models.Mol Pharm2019
29533601Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.Biochemistry2018
29867143Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.Nat Chem Biol2018
29915173Biosynthesis of thiocarboxylic acid-containing natural products.Nat Commun2018
30216060Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis.J Am Chem Soc2018
29806086Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Typeâ¿¿II Diterpene Synthases.Chembiochem2018
29937405Resistance to Enediyne Antitumor Antibiotics by Sequestration.Cell Chem Biol2018
30152678Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.ACS Chem Biol2018
30070831P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.Biochemistry2018
27507632Germicidins H-J from Streptomyces sp. CB00361.J Antibiot (Tokyo)2017
28237556In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin.Bioorg Med Chem2017
28465627Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid.J Antibiot (Tokyo)2017
28884166Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.ACS Omega2017
28758170Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.Nat Prod Rep2017
27865713Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine.Biochem Pharmacol2017
27490479Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.J Am Chem Soc2016
26318027Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.J Ind Microbiol Biotechnol2016
27966343Biosynthetic Origin of the Ether Ring in Platensimycin.J Am Chem Soc2016
27999165Strain Prioritization and Genome Mining for Enediyne Natural Products.mBio2016
27599271A Mutasynthetic Library of Platensimycin and Platencin Analogues.Org Lett2016
27560143Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.Biochemistry2016
27406907Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.J Antibiot (Tokyo)2016
27134119Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029.Bioorg Med Chem2016
25434000Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.Bioorg Med Chem Lett2015
26335269Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion.J Nat Prod2015
26512730Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.Biochemistry2015
26055255A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase.Mol Biosyst2015
24484381Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.J Nat Prod2014
25238028Strain prioritization for natural product discovery by a high-throughput real-time PCR method.J Nat Prod2014
25299801BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.Biochemistry2014
25019332Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis.Org Lett2014
24560608Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.Chem Biol2014
23301871Multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase.J Am Chem Soc2013
23848360Correction to multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase.J Am Chem Soc2013
24083562Tyrosine O-prenyltransferase SirD catalyzes S-, C-, and N-prenylations on tyrosine and tryptophan derivatives.ACS Chem Biol2013
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Collaborators

Rice University
Co-authored papers 9
Argonne National Laboratory
Co-authored papers 8
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 8
University of Utah
Co-authored papers 3
Argonne National Laboratory
Co-authored papers 2
University of Florida
Co-authored papers 1
National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 1
Rice University
Co-authored papers 1
European Bioinformatics Institute (EMBL-EBI)
Co-authored papers 1
University of Hong Kong
Co-authored papers 1
University of Florida
Co-authored papers 1
Tianjin University of Traditional Chinese Medicine
Co-authored papers 1
Google Research
Co-authored papers 1
carnegie mellon university
Co-authored papers 1
Institute for Integrative Systems Biology, Spanish National Research Council (CSIC)
Co-authored papers 1
University of Florida Citrus Research and Education Center
Co-authored papers 1
Institut Francois Jacob, CNRS, Universite d'Evry, Universite Paris-Saclay
Co-authored papers 1
Co-authored papers 1
Genetics Institute, University of Florida
Co-authored papers 1
University of Florida
Co-authored papers 1
University of Delaware
Co-authored papers 1
Lawrence Berkeley National Laboratory
Co-authored papers 1
Center for the Study of Biological Complexity, Virginia Commonwealth University
Co-authored papers 1
New England Biolabs Inc.
Co-authored papers 1
Iowa State University
Co-authored papers 1
University of California at San Diego
Co-authored papers 1
University of Cambridge
Co-authored papers 1
Pangea Systems Inc., USA and Marine Biological Laboratory
Co-authored papers 1
The Pennsylvania State University, University Park
Co-authored papers 1
University of Florida
Co-authored papers 1