Author details

Full Name

Alberto Ambesi-Impiombato

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37560472	Enrichment analysis of phenotypic data for drug repurposing in rare diseases.		2023
36278490	Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model.	JCI insight	2022
33309017	Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress.	Biological Psychiatry	2021
32924017	Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia.	Blood Cancer Discov	2020
33796864	Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia.	Nat Cancer	2020
30567843	<i>Phf6</i> Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL.	Cancer Discov	2019
29170254	loss attenuates the TP53-induced DNA damage response in T-cell acute lymphoblastic leukemia.	Haematologica	2018
29990496	Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.	Cancer Cell	2018
30038221	Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.	Nature Medicine	2018
29398449	RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.	Cancer Cell	2018
29342136	Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia.	Nature	2018
28174276	Synergistic antileukemic therapies in <i>NOTCH1</i>-induced T-ALL.	Proc Natl Acad Sci U S A	2017
29083320	Pharmacological inhibition of the transcription factor PU.1 in leukemia.	J Clin Invest	2017
27799065	A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma.	Genome Med	2016
27655895	Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.	Proc Natl Acad Sci U S A	2016
26390244	Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.	Nature Medicine	2015
25378249	Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.	Genome Res	2015
25784680	Therapeutic targeting of HES1 transcriptional programs in T-ALL.	Blood	2015
25194570	A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.	Nat Med	2014
24413734	Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.	Nat Genet	2014
25050160	Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).	ACS Med Chem Lett	2014
23687089	Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia.	Blood	2013
23908464	Genetic loss of SH2B3 in acute lymphoblastic leukemia.	Blood	2013
24291004	Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia.	Cancer Cell	2013
22366949	Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.	Nat Med	2012
22504949	Preclinical analysis of the Î³-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia.	Molecular Cancer Therapeutics	2012
22162831	ETV6 mutations in early immature human T cell leukemias.	Journal of Experimental Medicine	2011
20147574	Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genes.	Journal of Psychopharmacology	2011
20060366	The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia.	Cancer Cell	2010
19243698	Dopamine receptor subtypes contribution to Homer1a induction: insights into antipsychotic molecular action.	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2009
18441228	Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering.	Genome Research	2008
17299415	How to infer gene networks from expression profiles.	Molecular Systems Biology	2007
17372981	Differential expression of Homer 1 gene by acute and chronic administration of antipsychotics and dopamine transporter inhibitors in the rat forebrain.	Synapse	2007
17317002	Ketamine-related expression of glutamatergic postsynaptic density genes: possible implications in psychosis.	Neuroscience Letters	2007
17118162	Computational framework for the prediction of transcription factor binding sites by multiple data integration.	BMC Neurosci	2006
16107787	Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.	Journal of Cerebral Blood Flow and Metabolism	2006
16141072	The transcriptional landscape of the mammalian genome.	Science	2005
12842224	Method for quantitative in situ hybridization histochemistry and image analysis applied for Homer1a gene expression in rat brain.	Brain Research Protocols	2003
12464447	Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of D-cycloserine.	Neuropsychopharmacology	2002
12372549	Decreased gene expression of calretinin and ryanodine receptor type 1 in tottering mice.	Brain Research Bulletin	2002
11834303	Acute administration of antipsychotics modulates Homer striatal gene expression differentially.	Molecular Brain Research	2002