Author details

Full Name

Anna Greka

Affiliation

ORCID

Career Start Year

1998

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36862513	A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis.	J Clin Invest	2023
36894557	N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model.		2023
36763970	Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond.		2023
37075753	FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.	Cell Metab	2023
37063857	Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution.		2023
36865221	FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.	bioRxiv	2023
34732507	Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology.	J Am Soc Nephrol	2022
35372810	High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways.	iScience	2022
35557491	Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1-Alkyl-2-(pyrrolidin-1-yl)-1H-benzo[d]imidazoles as Potent and Selective Inhibitors.	ChemMedChem	2022
35549429	Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function.	Science	2022
34861215	Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury.	American Journal of Pathology	2022
35069263	Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue.	Frontiers in Physiology	2021
33883744	Gasdermin D pore structure reveals preferential release of mature interleukin-1.	Nature	2021
33618515	Multigram Preparation of BRD4780 Enantiomers and Assignment of Absolute Stereochemistry.	Journal of Organic Chemistry	2021
33933453	PIP regulation of TRPC5 channel activation and desensitization.	Journal of Biological Chemistry	2021
33444290	Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease.	J Clin Invest	2021
33341352	A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies.	Trends in Molecular Medicine	2021
34621762	TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models.	Frontiers in Medicine	2021
34547235	Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity.	Molecular Cell	2021
31337885	Outcomes of patient self-referral for the diagnosis of several rare inherited kidney diseases.	Genet Med	2020
31819231	The power of one: advances in single-cell genomics in the kidney.	Nature Reviews Nephrology	2020
32450155	Clinical and genetic spectra of autosomal dominant tubulointerstitial kidney disease due to mutationsÂ in UMOD and MUC1.	Kidney Int	2020
33376219	HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes.	Proc Natl Acad Sci U S A	2020
32637960	A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.	bioRxiv	2020
33294858	A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.	Cell Rep Med	2020
31348885	Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.	Cell	2019
31784515	Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation.	Nat Commun	2019
31704171	Charting a TRP to Novel Therapeutic Destinations for Kidney Diseases.	Trends in Pharmacological Sciences	2019
30538066	Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903.	Bioorganic and Medicinal Chemistry Letters	2019
29249695	GDC-0879, a BRAF<sup>V600E</sup> Inhibitor, Protects Kidney Podocytes from Death.	Cell Chem Biol	2018
29967284	Noninvasive Immunohistochemical Diagnosis and Novel <i>MUC1</i> Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease.	J Am Soc Nephrol	2018
30467180	Structures and gating mechanism of human TRPM2.	Science	2018
29467330	Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.	JCI insight	2018
28033563	The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.	Redox Biology	2017
28912266	Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.	J Biol Chem	2017
29217578	A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.	Science	2017
29340321	Randomized Clinical Trial Design to Assess Abatacept in Resistant Nephrotic Syndrome.	Kidney Int Rep	2017
27298238	Differential associations between systemic markers of disease and white matter tissue health in middle-aged and older adults.	J Cereb Blood Flow Metab	2017
27628902	Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.	Journal of the American Society of Nephrology : JASN	2017
27987540	Introduction: Toward Precision Medicines for Kidney Disease.	Seminars in Nephrology	2016
26808706	Human genetics of nephrotic syndrome and the quest for precision medicine.	Current Opinion in Nephrology and Hypertension	2016
27029425	Calcium-permeable ion channels in the kidney.		2016
26490951	Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies.	Pediatric Nephrology	2016
27845869	Immune Complex-Mediated Proliferative Glomerulonephritis Induced by Paclitaxel Treatment.	Journal of Oncology Practice	2016
27987543	Personalized Comments on Challenges and Opportunities in Kidney Disease Therapeutics: The Glom-NExT Symposium.	Semin Nephrol	2016
27987542	An Introduction to the Glom-NExT Inaugural Symposium: Toward Precision Medicine in Nephrology.	Seminars in Nephrology	2016
26050127	Developing therapeutic 'arrows' with the precision of William Tell: the time has come for targeted therapies in kidney disease.	Current Opinion in Nephrology and Hypertension	2015
26228159	Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.	Science	2015
24625832	An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts.	PLoS One	2014
24670178	Abatacept in B7-1-positive proteinuric kidney disease.	New England Journal of Medicine	2014