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Author Details

Ivan Topisirovic
McGill University
2001
128
52
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36920785The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.Blood Adv2023
37736739Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.Biol Direct2023
34599983Regulation of gene expression via translational buffering.Biochim Biophys Acta Mol Cell Res2022
35561126Arginyl-tRNA-protein transferase 1 (ATE1) promotes melanoma cell growth and migration.FEBS Lett2022
35858571Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.Cell Rep2022
35385705Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.Cell Metab2022
36532738Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex.Front Pharmacol2022
35993810Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade.Nucleic Acids Res2022
35977476Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids.Cell Rep2022
35302710Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells.FEBS Open Bio2022
33067172Cancer Plasticity: The Role of mRNA Translation.Trends Cancer2021
33784591Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin.Neoplasia2021
33690225Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.J Clin Invest2021
34616097Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.Nat Chem Biol2021
34547241A hydride transfer complex reprograms NAD metabolism and bypasses senescence.Mol Cell2021
34686314Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.Mol Cell2021
34188221Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.Nat Chem Biol2021
33989699The role of GSK3 in metabolic pathway perturbations in cancer.Biochim Biophys Acta Mol Cell Res2021
34039602Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR.Sci Adv2021
34168367Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.Nat Chem Biol2021
34083537STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.Nat Commun2021
34330898The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.Nat Commun2021
34022133Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK.Dev Cell2021
32427827Translational control of breast cancer plasticity.Nat Commun2020
33027666The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest.Cell Rep2020
32665551PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis.Nat Commun2020
32571981SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth.Mol Cancer Res2020
32709883Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nat Commun2020
32755594Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.Mol Cell2020
30612740METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.Cell2019
31699971RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity.Cell Death Dis2019
31800587Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation.PLoS Biol2019
31740775Translational reprogramming marks adaptation to asparagine restriction in cancer.Nat Cell Biol2019
30072418Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia.J Mol Endocrinol2019
31556460Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression.EMBO J2019
31209069c-Myc steers translation in lymphoma.J Exp Med2019
31263101An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.Nat Commun2019
31316753mTOR as a central regulator of lifespan and aging.F1000Res2019
30926999Generally applicable transcriptome-wide analysis of translation using anota2seq.Nucleic Acids Res2019
30926667Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.Proc Natl Acad Sci U S A2019
29150352Dysregulation of mRNA translation and energy metabolism in cancer.Adv Biol Regul2018
29930100Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.Cancer Res2018
30224182Translation Links Nutrient Availability with Inflammation.Trends Biochem Sci2018
30244971Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.Cell Metab2018
29449538Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.Cell Death Dis2018
29610153Signaling Pathways Involved in the Regulation of mRNA Translation.Mol Cell Biol2018
29179096Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.Curr Opin Genet Dev2018
28918902mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.Mol Cell2017
28277937mTOR-sensitive translation: Cleared fog reveals more trees.RNA Biol2017
29035277MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.J Clin Invest2017
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Collaborators

David Papadopoli
McGill University
Co-authored papers 12
Ze'ev Ronai
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 9
Yongmei Feng
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 6
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Biomedicine Discovery Institute, Monash University
Co-authored papers 3
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IRIC - University of Montreal
Co-authored papers 3
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Memorial Sloan-Kettering Cancer Center
Co-authored papers 3
Tony Pawson
Co-authored papers 2
Richard J Rebello
University of Melbourne
Co-authored papers 2
Gail P Risbridger
Biomedicine Discovery Institute, Monash University
Co-authored papers 2
Veronica Clavijo Jordan
Harvard Medical School
Co-authored papers 2
Olivier Le Bacquer
Co-authored papers 2
Brian James
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Hyungsoo Kim
Sungkyunkwan University
Co-authored papers 2
Sylvain Meloche
Institute for Research in Immunology and Cancer
Co-authored papers 2
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Queen's University Belfast
Co-authored papers 1
Zachary Steinhart
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 1
Rabi Murad
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Jan Paul Medema
Oncode Institute
Co-authored papers 1
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 1
Reinhard Dummer
University Hospital Zurich
Co-authored papers 1
Arianna L Kim
Co-authored papers 1
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 1
Joshua E Elias
Addenbrooke's Hospital, University of Cambridge
Co-authored papers 1
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 1
Mathieu Tremblay
Universite de Montreal, Institute for Research in Immunology and Cancer
Co-authored papers 1
David Sulzer
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
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Ernst J Wolvetang
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