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| 36905647 | Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer. | IUBMB Life | 2023 |
| 37647388 | A blood-based marker of mitochondrial DNA damage in Parkinson's disease. | Sci Transl Med | 2023 |
| 37155866 | Golgi-IP, a tool for multimodal analysis of Golgi molecular content. | Proc Natl Acad Sci U S A | 2023 |
| 37083530 | Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i>-ALS iPSC-derived microglia contributes to neurodegeneration. | Sci Adv | 2023 |
| 36971062 | The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity. | Mov Disord | 2023 |
| 36007011 | Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. | J Am Chem Soc | 2022 |
| 36424392 | Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. | NPJ Parkinsons Dis | 2022 |
| 36149401 | A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. | Elife | 2022 |
| 36040231 | PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. | Biochem J | 2022 |
| 35950872 | Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding. | Biochem J | 2022 |
| 33367571 | Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites. | Biochem J | 2021 |
| 33682442 | Role of KLHL3 and dietary K<sup>+</sup> in regulating KS-WNK1 expression. | Am J Physiol Renal Physiol | 2021 |
| 33913039 | LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies. | Acta Neuropathol | 2021 |
| 34580980 | Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. | EMBO Rep | 2021 |
| 34515301 | Impact of Type II LRRK2 inhibitors on signaling and mitophagy. | Biochem J | 2021 |
| 34658337 | Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain. | Elife | 2021 |
| 34652918 | Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins. | J Med Chem | 2021 |
| 34125248 | R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils. | Acta Neuropathol | 2021 |
| 32250352 | Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation. | J Vis Exp | 2020 |
| 32017888 | Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2. | Structure | 2020 |
| 32036294 | Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease. | Curr Opin Cell Biol | 2020 |
| 33060197 | Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. | Science | 2020 |
| 33135724 | Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. | Biochem J | 2020 |
| 32601174 | Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. | Mol Cell Proteomics | 2020 |
| 30635421 | Crystal structure of the WD40 domain dimer of LRRK2. | Proc Natl Acad Sci U S A | 2019 |
| 31665227 | Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44. | Biochem J | 2019 |
| 31663853 | PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. | Elife | 2019 |
| 31461270 | Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. | ACS Chem Biol | 2019 |
| 31624137 | Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases. | J Cell Biol | 2019 |
| 30978004 | Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. | ACS Chem Biol | 2019 |
| 30554956 | Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1. | Bioorg Med Chem Lett | 2019 |
| 30647193 | Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. | EMBO J | 2019 |
| 28877076 | Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II. | J Hypertens | 2018 |
| 30102854 | Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. | ACS Chem Biol | 2018 |
| 30045977 | LRRK2 activation in idiopathic Parkinson's disease. | Sci Transl Med | 2018 |
| 30142342 | PP1 Phosphatase Complexes: Undruggable No Longer. | Cell | 2018 |
| 30194047 | Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice. | Neurobiol Dis | 2018 |
| 30398148 | A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. | Elife | 2018 |
| 29743203 | The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. | Biochem J | 2018 |
| 29789389 | LRRK2 is a negative regulator of <i>Mycobacterium tuberculosis</i> phagosome maturation in macrophages. | EMBO J | 2018 |
| 29622645 | LRRK2 kinase in Parkinson's disease. | Science | 2018 |
| 29127255 | Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. | Biochem J | 2018 |
| 29127256 | Development of phospho-specific Rab protein antibodies to monitor <i>in vivo</i> activity of the LRRK2 Parkinson's disease kinase. | Biochem J | 2018 |
| 29150437 | Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks. | Biochem J | 2018 |
| 29212815 | Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. | EMBO J | 2018 |
| 27859053 | B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice. | Eur J Immunol | 2017 |
| 28353288 | Small-Molecule Inhibitors of LRRK2. | Adv Neurobiol | 2017 |
| 28341841 | Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains. | Sci Rep | 2017 |
| 29125462 | Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. | Elife | 2017 |
| 29045385 | USP7 small-molecule inhibitors interfere with ubiquitin binding. | Nature | 2017 |