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Author Details

Michael J Trnka
Department of Pharmaceutical Chemistry, University of California San Francisco
1995
32
21
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36634736In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization.Mol Cell Proteomics2023
35963430Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants.J Biol Chem2022
35756531Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.Chem Sci2022
34619147Heterodimerization of H3K9 histone methyltransferases G9a and GLP activates methyl reading and writing capabilities.J Biol Chem2021
34380736RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.Proc Natl Acad Sci U S A2021
34634033SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.PLoS Biol2021
32494070LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation.Nature2020
32912968A Novel Mechanism for NF-κB-activation via IκB-aggregation: Implications for Hepatic Mallory-Denk-Body Induced Inflammation.Mol Cell Proteomics2020
32820719An ER translocon for multi-pass membrane protein biogenesis.Elife2020
30626866Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling.Nat Commun2019
31618757HP1 reshapes nucleosome core to promote phase separation of heterochromatin.Nature2019
31045356First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.Anal Chem2019
30890443Role of integrative structural biology in understanding transcriptional initiation.Methods2019
29664398The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h.Elife2018
30308158A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.Cell Host Microbe2018
28636604Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.Nature2017
28591576Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones.Cell Rep2017
26706127Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.J Biol Chem2016
27610567Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex.Cell2016
25451919Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes.J Biol Chem2015
26323614Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes.J Am Soc Mass Spectrom2015
26402457Molecular architecture of the yeast Mediator complex.Elife2015
26189511Deconvolution method for specific and nonspecific binding of ligand to multiprotein complex by native mass spectrometry.Anal Chem2015
24335475Matching cross-linked peptide spectra: only as good as the worse identification.Mol Cell Proteomics2014
23601638Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase.Chem Biol2013
23071300Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II.Proc Natl Acad Sci U S A2012
21399817The role of conformational flexibility on protein supercharging in native electrospray ionization.Phys Chem Chem Phys2011
20813910Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of both peptide sequences and their attachment sites.Mol Cell Proteomics2010
19135260Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand.J Inorg Biochem2009
18998650Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.J Am Chem Soc2008
16321358Photoaffinity labeling of P450Cam by an imidazole-tethered benzophenone probe.Arch Biochem Biophys2006
7741218Configurations of a flow injection system for perfusion studies of adherent cells.Anal Chem1995
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Collaborators

Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 21
Philip J Robinson
College of Medical Veterinary and Life Sciences, University of Glasgow
Co-authored papers 7
Geeta J Narlikar
University of California san francisco
Co-authored papers 5
Danica Galoni?? Fujimori
University of California San Francisco
Co-authored papers 4
David A Bushnell
Stanford University
Co-authored papers 4
John D Gross
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Roger D Kornberg
Stanford University
Co-authored papers 3
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Wah Chiu
Stanford University
Co-authored papers 2
Ralph E Davis
Stanford University School of Medicine
Co-authored papers 2
Patrick R Griffin
The Scripps Research Institute
Co-authored papers 2
Jonathan B Johnston
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Riccardo Pellarin
CNRS UMR 5086 and Universite Claude Bernard Lyon 1
Co-authored papers 2
Christoph H Borchers
McGill University
Co-authored papers 1
Marta Vilaseca
Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
Co-authored papers 1
Alexander Leitner
ETH Zurich
Co-authored papers 1
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 1
David A Agard
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 1
Robert L Moritz
Institute for Systems Biology
Co-authored papers 1
David J Stanley
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
James E Longbotham
University of California San Francisco
Co-authored papers 1
Andrea Sinz
Center for Structural Mass Spectrometry, Martin Luther University Halle-Wittenberg
Co-authored papers 1
Petr Nov??k
Institute of Microbiology of the CAS
Co-authored papers 1
Ignacia Echeverria
University of California san francisco
Co-authored papers 1
Nir Kalisman
Institute of Life Sciences, The Hebrew University
Co-authored papers 1
Juri Rappsilber
Institute for Biotechnology, Technical University Berlin
Co-authored papers 1
Michael J MacCoss
University of Washington
Co-authored papers 1
Adam Frost
University of California San Francisco
Co-authored papers 1
James E Bruce
Co-authored papers 1
Judith Frydman
Stanford University
Co-authored papers 1
Release 1.2