Author details

Full Name

Marc van de Wetering

Affiliation

Princess Maxima Center for Pediatric Oncology

ORCID

Career Start Year

1991

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37020038	Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.	Oncogene	2023
37883554	Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.	Science	2023
37823774	Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells.	Cancer Res Commun	2023
35916583	Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes.	EMBO Mol Med	2022
35469014	Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR Ã¿ LGR5 bispecific antibody with efficacy in epithelial tumors.	Nat Cancer	2022
34885181	EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.	Cancers (Basel)	2021
33500353	Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.	Proc Natl Acad Sci U S A	2021
31036964	Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids.	Nat Genet	2019
31843916	Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion.	Proc Natl Acad Sci U S A	2019
31282586	Xenograft and organoid model systems in cancerÂ research.	EMBO J	2019
29311336	Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.	Proc Natl Acad Sci U S A	2018
29643510	Intra-tumour diversification in colorectal cancer at the single-cell level.	Nature	2018
28052255	Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer.	Cell Rep	2017
28850106	FANTOM5 CAGE profiles of human and mouse samples.	Sci Data	2017
28716720	MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.	Gastroenterology	2017
28684519	Origins of lymphatic and distant metastases in human colorectal cancer.	Science	2017
27698416	Tissue-specific mutation accumulation in human adult stem cells during life.	Nature	2016
25307862	In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.	Gastroenterology	2015
26460009	Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.	Proc Natl Acad Sci U S A	2015
25924068	Sequential cancer mutations in cultured human intestinal stem cells.	Nature	2015
25957691	Prospective derivation of a living organoid biobank of colorectal cancer patients.	Cell	2015
25712196	Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.	J Pathol	2015
25533785	Long-term culture of genome-stable bipotent stem cells from adult human liver.	Cell	2015
23318432	Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling.	Oncogene	2014
25500896	Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.	Nat Commun	2014
25043003	Genome sequencing of normal cells reveals developmental lineages and mutational processes.	Nature	2014
24670764	A promoter-level mammalian expression atlas.	Nature	2014
23354049	In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.	Nature	2013
24045232	Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.	EMBO J	2013
24120136	Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.	Cell	2013
23714178	DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.	Genome Biol	2013
23545496	ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.	Cell Rep	2013
22388892	Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.	Nat Cell Biol	2012
23000963	Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.	Nat Cell Biol	2012
22999937	Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.	Cell Rep	2012
22692129	The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.	EMBO J	2012
22895187	Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.	Nature	2012
22855427	Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.	Science	2012
21113151	Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.	Nature	2011
22081019	Single-cell dissection of transcriptional heterogeneity in human colon tumors.	Nat Biotechnol	2011
21727895	Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.	Nature	2011
21696214	Highly sensitive proteome analysis of FACS-sorted adult colon stem cells.	J Proteome Res	2011
21297579	Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.	EMBO J	2011
20085740	Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.	Cell Stem Cell	2010
21152096	Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.	PLoS One	2010
20223988	Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.	Science	2010
19013005	Identification of primary MAFB target genes in multiple myeloma.	Exp Hematol	2009
19329995	Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.	Nature	2009
19450592	OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.	Gastroenterology	2009
19092804	Crypt stem cells as the cells-of-origin of intestinal cancer.	Nature	2009

1 - 50 of 99

Rahul K Kollipara

McDermott Center for Human Growth and Development.

Career Start Year 2010

Number of shared co-authors 0

Richard Mitter

The Francis Crick Institute

Career Start Year 2008

Number of shared co-authors 3

Henry Yang

Cancer Science Institute of Singapore, National University of Singapore

Career Start Year 2005

Number of shared co-authors 4

Mathieu Tremblay

Universite de Montreal, Institute for Research in Immunology and Cancer

Career Start Year 2003

Number of shared co-authors 0

Susan L Woods

Adelaide Medical School, University of Adelaide

Career Start Year 2002

Number of shared co-authors 1

Vitezslav Bryja

Masaryk University

Career Start Year 2001

Number of shared co-authors 2

Mariano Loza-Coll

California State University

Career Start Year 1999

Number of shared co-authors 0

Gregory S Yochum

The Pennsylvania State University College of Medicine

Career Start Year 1998

Number of shared co-authors 0

Keiko Akagi

The University of Texas MD Anderson Cancer Center

Career Start Year 1997

Number of shared co-authors 2

Robert L Walker

Center for Cancer Research, National Cancer Institute, National Institutes of Health

Career Start Year 1997

Number of shared co-authors 1

Peter C Scacheri

Case Western Reserve University School of Medicine

Career Start Year 1995

Number of shared co-authors 3

Celio Pouponnot

Institut Curie

Career Start Year 1993

Number of shared co-authors 1

Pedro Aza-Blanc

Sanford-Burnham-Prebys Medical Discovery Institute

Career Start Year 1993

Number of shared co-authors 1

Jeffrey J Delrow

Clinical Research Division, Fred Hutchinson Cancer Research Center

Career Start Year 1992

Number of shared co-authors 0

Sergei G Tevosian

University of Florida College of Veterinary Medicine

Career Start Year 1990

Number of shared co-authors 0

Sean M Grimmond

The University of Melbourne

Career Start Year 1990

Number of shared co-authors 86

Dirk Geerts

Amsterdam University Medical Center

Career Start Year 1989

Number of shared co-authors 2

Dieter Weichenhan

German Cancer Research Center (DKFZ)

Career Start Year 1988

Number of shared co-authors 4

Kristian Helin

The Institute of Cancer Research

Career Start Year 1988

Number of shared co-authors 11

Martin J Walsh

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai

Career Start Year 1987

Number of shared co-authors 0

Yoshiaki Ito

Tokyo Medical and Dental University (TMDU)

Career Start Year 1987

Number of shared co-authors 2

Brandon J Wainwright

The University of Queensland Diamantina Institute, The University of Queensland

Career Start Year 1985

Number of shared co-authors 10

Tarik M??r??y

Institut de recherches cliniques de Montreal

Career Start Year 1985

Number of shared co-authors 0

Kornel E Schuebel

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health

Career Start Year 1985

Number of shared co-authors 0

David D L Bowtell

Peter MacCallum Cancer Centre

Career Start Year 1983

Number of shared co-authors 11

Colin R Goding

Ludwig Institute for Cancer Research, University of Oxford

Career Start Year 1983

Number of shared co-authors 3

David J Adams

Wellcome Sanger Institute

Career Start Year 1980

Number of shared co-authors 28

Barbara J Wold

Merkin Institute for Translational Research, California Institute of Technology

Career Start Year 1976

Number of shared co-authors 11

Bruce J Aronow

Cincinnati Children's Hospital Medical Center

Career Start Year 1975

Number of shared co-authors 7

Mario R Capecchi

University of Utah School of Medicine

Career Start Year 1965

Number of shared co-authors 0

row(s) 1 - 30 of 30

Hans Clevers

Princess Maxima Center for Pediatric Oncology

Co-authored papers 95

Edwin Cuppen

Hartwig Medical Foundation

Co-authored papers 8

Frank C P Holstege

Princess Maxima Center for Pediatric Oncology

Co-authored papers 6

Albert J R Heck

Utrecht University

Co-authored papers 5

Jan Koster

Amsterdam University Medical Centers location AMC

Co-authored papers 5

Michael R Stratton

Wellcome Sanger Institute

Co-authored papers 5

Thanasis Margaritis

Princess Maxima Center for Pediatric Oncology

Co-authored papers 3

Tony J Kenna

Queensland University of Technology

Co-authored papers 2

Marielle E van Gijn

University Medical Center Groningen

Co-authored papers 2

Peter Zhang

Child and Family Research Institute, University of British Columbia

Co-authored papers 2

Naoto Kondo

Nagoya City University Graduate School of Medical Sciences

Co-authored papers 2

Takaaki Sugiyama

Co-authored papers 2

Jun Furusawa

Aichi Cancer Center Hospital

Co-authored papers 2

Guojun Sheng

International Research Center for Medical Sciences (IRCMS), Kumamoto University

Co-authored papers 2

Yosuke Mizuno

Yokohama National University

Co-authored papers 2

Haruhiko Koseki

RIKEN Research Center for Allergy and Immunology

Co-authored papers 2

Stefano Gustincich

Istituto Italiano di Tecnologia

Co-authored papers 2

Yuki I Kawamura

Research Institute, National Center for Global Health and Medicine

Co-authored papers 2

Reto Guler

International Centre for Genetic Engineering and Biotechnology

Co-authored papers 2

Albert S B Edge

Harvard Medical School

Co-authored papers 2

Christophe Simon

RIKEN Yokohama Institute

Co-authored papers 2

Peter Heutink

German Center for Neurodegenerative Diseases (DZNE).

Co-authored papers 2

Ernst J Wolvetang

Australian Institute for Bioengineering and Nanotechnology, University of Queensland

Co-authored papers 2

Suzana Savvi

South African Medical Research Council (SAMRC), University of Cape Town

Co-authored papers 2

Soichi Ogishima

Tohoku University Graduate School of Medicine

Co-authored papers 2

Christine L Mummery

Leiden University Medical Center

Co-authored papers 2

Weonju Lee

Kyungpook National University, Kyungpook National University Hospital

Co-authored papers 2

Yohei Yonekura

RIKEN Center for Developmental Biology

Co-authored papers 2

Carsten O Daub

International Institute of Molecular and Cell Biology in Warsaw

Co-authored papers 2

Noriko Ninomiya

Japan Tobacco Inc.

Co-authored papers 2

1 - 30

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