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Author Details

Paul S Mischel
Stanford University
1994
236
92
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37162993Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors.bioRxiv2023
37755062Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of "metabolism-based pathology".Pathol Int2023
37961138Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair.bioRxiv2023
37945900Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma.Nat Genet2023
37503111Coordinated inheritance of extrachromosomal DNA species in human cancer cells.bioRxiv2023
37155843Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity.Proc Natl Acad Sci U S A2023
37017374A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death.J Am Chem Soc2023
37046089Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus.Nature2023
34752712Extrachromosomal DNA: An Emerging Hallmark in Human Cancer.Annu Rev Pathol2022
35609926Extrachromosomal DNA in Cancer.Annu Rev Genomics Hum Genet2022
36524349Correction: PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.Cancer Res2022
35999307Form follows function in cancer genomes.Nat Cancer2022
36131011Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges.Nat Rev Clin Oncol2022
36355400Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance.Biochem Soc Trans2022
36351387Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation.Cell Rep2022
36123406The evolutionary dynamics of extrachromosomal DNA in human cancers.Nat Genet2022
35948767Gene regulation on extrachromosomal DNA.Nat Struct Mol Biol2022
35271755The metabolomic landscape plays a critical role in glioma oncogenesis.Cancer Sci2022
35140399Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.Nature2022
33477016Extrachromosomal DNA (ecDNA) in cancer pathogenesis.Curr Opin Genet Dev2021
33916219Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer.Metabolites2021
34819668ecDNA hubs drive cooperative intermolecular oncogene expression.Nature2021
34548317Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription.Clin Cancer Res2021
34518527Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.Nat Commun2021
34593944BAP1 methylation: a prognostic marker of uveal melanoma metastasis.NPJ Precis Oncol2021
31575654Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations.Mol Cancer Ther2020
31992716Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.Nat Commun2020
31806884Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets.Nat Rev Cancer2020
32807987Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.Nat Genet2020
32931740Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma.Cancer Cell2020
32873787AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications.Nat Commun2020
32366675Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM.Mol Cancer Res2020
32312984Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.Nat Commun2020
32275948Extrachromosomal DNA-relieving heredity constraints, accelerating tumour evolution.Ann Oncol2020
32470125What Is Extrachromosomal Circular DNA and What Does It Do?Clin Chem2020
32145344mTOR complex 2 is an integrator of cancer metabolism and epigenetics.Cancer Lett2020
30609184Metabolic reprogramming in the pathogenesis of glioma: Update.Neuropathology2019
31712311mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma.J Biol Chem2019
31706138EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA.iScience2019
30078714Breast cancer treatment and its effects on aging.J Geriatr Oncol2019
31303424Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.Cell Metab2019
31371825IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.Nat Cell Biol2019
31201181Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling.Cancer Discov2019
31391321Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells.Sci Transl Med2019
31390546Acyl-CoA-Binding Protein Fuels Gliomagenesis.Cell Metab2019
30872802Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.Nat Rev Cancer2019
30846550A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.Proc Natl Acad Sci U S A2019
31019297NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.Nature2019
30674876Exploring the landscape of focal amplifications in cancer using AmpliconArchitect.Nat Commun2019
28892308Targeting epidermal growth factor receptor co-dependent signaling pathways in glioblastoma.Wiley Interdiscip Rev Syst Biol Med2018
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David Geffen School of Medicine, University of California Los Angeles
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Co-authored papers 40
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university of california los angeles
Co-authored papers 27
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University of California San Diego
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Co-authored papers 18
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David Geffen School of Medicine, University of California los angeles
Co-authored papers 17
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Co-authored papers 16
Jens Luebeck
University of California San Diego
Co-authored papers 13
Charles D James
Co-authored papers 9
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University of California san francisco
Co-authored papers 7
James R Heath
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Howard Y Chang
Center for Personal Dynamic Regulomes, Stanford University
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Kan V Lu
Clinical Medical Research Center of Hepatic Surgery at Hubei Province
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Charles L Sawyers
Memorial Sloan Kettering Cancer Center
Co-authored papers 6
Benjamin M Ellingson
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 6
Anton G Henssen
Co-authored papers 5
Antoni Ribas
University of California Los Angeles (university of california los angeles)
Co-authored papers 5
Cameron Brennan
Co-authored papers 5
Heather R Christofk
Jonsson Comprehensive Cancer Center, University of California los angeles
Co-authored papers 5
Bing Ren
Center for Epigenomics, University of California San Diego
Co-authored papers 5
Sameer Agnihotri
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Patrick Y Wen
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Rameen Beroukhim
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Minesh P Mehta
Co-authored papers 4
Jeremy N Rich
UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
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Scott R VandenBerg
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Release 1.2