Author details

Full Name

Vassilis Aidinis

Affiliation

ORCID

Career Start Year

1993

Papers

104

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37778471	L-Dopa decarboxylase modulates autophagy in hepatocytes and is implicated in dengue virus-caused inhibition of autophagy completion.		2024
36980473	SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts.		2023
37746070	Increased lipocalin-2 expression in pulmonary inflammation and fibrosis.		2023
37741346	Bioactive signalling lipids as drivers of chronic liver diseases.		2023
37735172	SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis.		2023
37795958	-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity.		2023
37964265	Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis.		2023
37958814	Increased Levels of Galectin-3 in Critical COVID-19.		2023
36766854	Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes.		2023
36702053	Hit to lead optimization and chemoinformatic studies for a new series of Autotaxin inhibitors.		2023
37007651	An explainable machine learning-driven proposal of pulmonary fibrosis biomarkers.		2023
37176032	The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer.		2023
35203702	Obesity Reshapes the Microbial Population Structure along the Gut-Liver-Lung Axis in Mice.	Biomedicines	2022
36358855	Autotaxin in Breast Cancer: Role, Epigenetic Regulation and Clinical Implications.	Cancers	2022
35887265	Autotaxin Has a Negative Role in Systemic Inflammation.	International Journal of Molecular Sciences	2022
36010216	Autotaxin Activity in Chronic Subdural Hematoma: A Prospective Clinical Study.	Diagnostics	2022
35806457	Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells.	International Journal of Molecular Sciences	2022
35409077	Promoter Methylation Correlates with Decreased Gene Expression in Breast Cancer: Implementation as a Liquid Biopsy Biomarker.	International Journal of Molecular Sciences	2022
34769391	Methylation in Health and Cancer.	International Journal of Molecular Sciences	2021
34045680	Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation.	Mucosal Immunology	2021
33995908	Systems biology reveals key tissue-specific metabolic and transcriptional signatures involved in the response of plant genotypes to salt stress.	Computational and Structural Biotechnology Journal	2021
33778909	A role for bronchial epithelial autotaxin in ventilator-induced lung injury.	Intensive Care Medicine Experimental	2021
33562347	Advances in de Novo Drug Design: From Conventional to Machine Learning Methods.	International Journal of Molecular Sciences	2021
33657371	Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.	Cell Reports	2021
33443087	MAP3K8 Regulates Cox-2-Mediated Prostaglandin E Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis.	Journal of Immunology	2021
33556824	Precision medicine in idiopathic pulmonary fibrosis therapy: From translational research to patient-centered care.	Current Opinion in Pharmacology	2021
34185793	Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform.	PLoS ONE	2021
34867934	Collagen 1a1 Expression by Airway Macrophages Increases In Fibrotic ILDs and Is Associated With FVC Decline and Increased Mortality.	Frontiers in Immunology	2021
34741074	Fibromine is a multi-omics database and mining tool for target discovery in pulmonary fibrosis.	Scientific Reports	2021
34576169	Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells.	International Journal of Molecular Sciences	2021
34671341	Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic Target.	Frontiers in Immunology	2021
32977539	Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors.	International Journal of Molecular Sciences	2020
32322056	Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.	Nature	2020
32240164	Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis.	PLoS ONE	2020
31864778	Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.	Bioorganic and Medicinal Chemistry	2020
30659895	Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis.	Pulmonary Pharmacology and Therapeutics	2019
31819797	Orotracheal treprostinil administration attenuates bleomycin-induced lung injury, vascular remodeling, and fibrosis in mice.	Pulmonary Circulation	2019
31652837	Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer.	Cancers	2019
30462853	Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials.	Medicinal Research Reviews	2019
31140976	Club cells form lung adenocarcinomas and maintain the alveoli of adult mice.	eLife	2019
31483681	Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2019
31471142	Autotaxin and chronic inflammatory diseases.	Journal of Autoimmunity	2019
29620892	Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.	Journal of Medicinal Chemistry	2018
30072447	Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.	Journal of Lipid Research	2018
30201409	Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.	Pulmonary Pharmacology and Therapeutics	2018
29868594	Mesenchymal Stem Cells for the Treatment of Idiopathic Pulmonary Fibrosis.	Frontiers in Medicine	2018
29951481	Autotaxin in Pathophysiology and Pulmonary Fibrosis.	Frontiers in Medicine	2018
30320115	Bleomycin Revisited: A Direct Comparison of the Intratracheal Micro-Spraying and the Oropharyngeal Aspiration Routes of Bleomycin Administration in Mice.	Frontiers in Medicine	2018
29724718	The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.	Cancer Research	2018
28274188	Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the 'bed' that counts and not 'the sleepers'.		2017