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Author Details

Felipe Diaz-Griffero
Albert Einstein College of Medicine
2002
109
46
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37414787Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection.Sci Rep2023
37292300Changes within the P681 residue of spike dictate cell fusion and syncytia formation of Delta and Omicron variants of SARS-CoV-2 with no effects on neutralization or infectivity.Heliyon2023
35215956TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection.Viruses2022
35891433Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection.Viruses2022
34321470SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.Nat Commun2021
33531504Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.Nat Commun2021
33604582Biochemical detection of capsid in the nucleus during HIV-1 infection.STAR Protoc2021
35005542GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors.iScience2021
34492268Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.J Biol Chem2021
34580332Nuclear restriction of HIV-1 infection by SUN1.Sci Rep2021
32187548Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.Cell Rep2020
32997983Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating.Cell Rep2020
30959264The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB.Virology2019
31501074Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus.EBioMedicine2019
31291579SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation.Cell Rep2019
31068426K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α.J Virol2019
29268082Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.Virology2018
29997211Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells.J Virol2018
30099227SAMHD1 deficient human monocytes autonomously trigger type I interferon.Mol Immunol2018
29884836Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.Nat Commun2018
30044979Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.Cell Rep2018
30009187Immune Responses to RNA Viruses.J Immunol Res2018
30257946IL-15 regulates susceptibility of CD4<sup>+</sup> T cells to HIV infection.Proc Natl Acad Sci U S A2018
30056211Binding of host factors to stabilized HIV-1 capsid tubes.Virology2018
29614111Correction: Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes.PLoS Pathog2018
29574335Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH.Virology2018
27748043The small-molecule 3G11 inhibits HIV-1 reverse transcription.Chem Biol Drug Des2017
28229507A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.Hum Mutat2017
29180435Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection.Proc Natl Acad Sci U S A2017
29191990Correction for Fricke et al., "Human Cytosolic Extracts Stabilize the HIV-1 Core".J Virol2017
26810656Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.Antimicrob Agents Chemother2016
27566548Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.J Biol Chem2016
27482511Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism.Virol Rep2016
27441239A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction.Heliyon2016
27511536Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.Sci Rep2016
26714703HIV-1 Capsid Stabilization Assay.Methods Mol Biol2016
27107820HIV-1 capsid is involved in post-nuclear entry steps.Retrovirology2016
26865710SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV.J Virol2016
25568212Contribution of MxB oligomerization to HIV-1 capsid binding and restriction.J Virol2015
26676782TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.J Virol2015
26719253MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells.J Virol2015
26212332RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin.Cell Rep2015
26121641Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells.PLoS Pathog2015
26063425Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal.J Virol2015
25744187Chromatin organization at the nuclear pore favours HIV replication.Nat Commun2015
25818806HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.Nat Commun2015
24158811The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating.Methods Mol Biol2014
25496772BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid.Retrovirology2014
25518861Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.Proc Natl Acad Sci U S A2014
25231297HIV-1 uncoating is facilitated by dynein and kinesin 1.J Virol2014
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Collaborators

Cindy Buffone
Albert Einstein College of Medicine
Co-authored papers 12
Anastasia Selyutina
Albert Einstein College of Medicine
Co-authored papers 11
Francesca Di Nunzio
Institut Pasteur, Universite Paris Cite
Co-authored papers 9
Alicia Martinez-Lopez
Instituto Murciano de Investigacion Biosanitaria (IMIB)-Pascual Parrilla
Co-authored papers 8
Mirjana Persaud
Albert Einstein College of Medicine
Co-authored papers 8
Edward M Campbell
Co-authored papers 7
Angel Bulnes-Ramos
Albert Einstein College of Medicine
Co-authored papers 4
Francine L Jacobson
Brigham and Women's Hospital
Co-authored papers 3
Fumiaki Hayashi
RIKEN Center for Life Science Technologies
Co-authored papers 3
Judd F Hultquist
Northwestern University Feinberg School of Medicine
Co-authored papers 3
Shigeyuki Yokoyama
Shinshu University School of Medicine
Co-authored papers 3
Matthew D Weitzman
The Children's Hospital of Philadelphia
Co-authored papers 2
Olivier Schwartz
Institut Pasteur, Universite Paris Cite, CNRS UMR9
Co-authored papers 2
Michael Dean
National Cancer Institute
Co-authored papers 2
Jeremy Luban
Co-authored papers 2
Mary Carrington
Frederick National Laboratory for Cancer Research, National Cancer Institute
Co-authored papers 1
Benhur Lee
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Rory Johnson
Co-authored papers 1
Wesley I Sundquist
University of Utah School of Medicine
Co-authored papers 1
Mark Scally
University of Texas Rio Grande Valley, 1201 West University Drive
Co-authored papers 1
Christopher Aiken
Co-authored papers 1
Susan T Weintraub
University of Texas Health Science Center at San Antonio Texas78229 USA.
Co-authored papers 1
Sevnur Kömürlü
Co-authored papers 1
Abraham L Brass
University of Massachusetts Medical School
Co-authored papers 1
Lara Manganaro
National Institute of Molecular Genetics, "Fondazione Romeo ed Enrica Invernizzi"
Co-authored papers 1
Donald S Burke
Graduate School of Public Health, University of Pittsburghgrid.21925.3d
Co-authored papers 1
John A T Young
Roche Pharma
Co-authored papers 1
Sanford D Markowitz
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Lubbertus C F Mulder
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Release 1.2