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Author Details

David C Wedge
Manchester Cancer Research Centre, University of Manchester
2006
116
58
PMIDPaper TitleJournal TitlePublished Year
36860655Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals <i>TP53</i> Aneuploidy-driven Metabolic Reprogramming.Cancer Res Commun2023
37828555Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine.Genome Med2023
36709352The genomic landscape and clonal evolutionary trajectory of classical hairy cell leukemia.Leukemia2023
34965940Benchmarking small-variant genotyping in polyploids.Genome Res2022
35637336In utero origin of myelofibrosis presenting in adult monozygotic twins.Nat Med2022
35597990APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types.BMC Biol2022
35460607Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.Am J Hum Genet2022
35659150Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study.Eur Urol2022
35450835Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups.Eur Urol Oncol2022
36045292African-specific molecular taxonomy of prostate cancer.Nature2022
35953478Clonal diversification and histogenesis of malignant germ cell tumours.Nat Commun2022
36388765Uncovering novel mutational signatures by <i>de novo</i> extraction with SigProfilerExtractor.Cell Genom2022
36085678A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples.Annu Int Conf IEEE Eng Med Biol Soc2022
35301290Multi-omic cross-sectional cohort study of pre-malignant Barrett's esophagus reveals early structural variation and retrotransposon activity.Nat Commun2022
33398189A practical guide to cancer subclonal reconstruction from DNA sequencing.Nat Methods2021
33627141Re-evaluating experimental validation in the Big Data Era: a conceptual argument.Genome Biol2021
33712835Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers.Am J Epidemiol2021
33782612A unified haplotype-based method for accurate and comprehensive variant calling.Nat Biotechnol2021
33782566Promises and challenges of adoptive T-cell therapies for solid tumours.Br J Cancer2021
33888445A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease.Eur Urol Oncol2021
34493867Genomic and evolutionary classification of lung cancer in never smokers.Nat Genet2021
34375606Tumor heterogeneity.Cancer Cell2021
34836952Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes.Nat Commun2021
34348967Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity.Cancer Res2021
32424208Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma.Nat Commun2020
31907488Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma.Nat Genet2020
33033260Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy.Nat Commun2020
33232318Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils.PLoS Biol2020
32855398Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases.Nat Commun2020
32895052Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression.BMC Biol2020
32555180The genomic and epigenomic evolutionary history of papillary renal cell carcinomas.Nat Commun2020
32437525Reference bias in the Illumina Isaac aligner.Bioinformatics2020
32229180Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration.J Mol Diagn2020
30692535Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Nat Commun2019
31806814Embryonal precursors of Wilms tumor.Science2019
31383035Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers.Breast Cancer Res2019
31444325Genomic landscape and chronological reconstruction of driver events in multiple myeloma.Nat Commun2019
30849372Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.Cell2019
29656891Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.Cell2018
30135448Genomic patterns of progression in smoldering multiple myeloma.Nat Commun2018
30177804The evolutionary landscape of colorectal tumorigenesis.Nat Ecol Evol2018
30061675Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.Nat Commun2018
30497530Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations.Genome Med2018
30374075Neutral tumor evolution?Nat Genet2018
30304655Classification and Personalized Prognosis in Myeloproliferative Neoplasms.N Engl J Med2018
30559362Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Nat Commun2018
29662167Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.Nat Genet2018
27062498Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution.Br J Haematol2017
28329761Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.Nature2017
28270531Principles of Reconstructing the Subclonal Architecture of Cancers.Cold Spring Harb Perspect Med2017
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Michael R Stratton
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Wellcome Sanger Institute
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Ultan McDermott
Wellcome Sanger Institute
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Moritz Gerstung
German Cancer Research Centre DKFZ
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Mark Maddison
Wellcome Sanger Institute
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Daniel S Brewer
University of Washington, USA Institute for Stem Cell and Regenerative Medicine
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Andrea L Richardson
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Charlie E Massie
University of Cambridge
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Claire Hardy
Wellcome Sanger Institute
Co-authored papers 9
Lucy A Stebbings
Wellcome Trust Sanger Institute
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Andy G Lynch
University of St Andrews
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Release 1.2