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Author Details

Helen He Zhu
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
2009
55
26
PMIDPaper TitleJournal TitlePublished Year
36544044TRIM59 is suppressed by androgen receptor and acts to promote lineage plasticity and treatment-induced neuroendocrine differentiation in prostate cancer.Oncogene2023
38016952The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer.Nat Commun2023
37707389An Early Neoplasia Index (ENI10), Based on Molecular Identity of CD10 Cells and Associated Stemness Biomarkers, is a Predictor of Patient Outcome in Many Cancers.Cancer Res Commun2023
37092583IL-1β Is an Androgen-Responsive Target in Macrophages for Immunotherapy of Prostate Cancer.Adv Sci (Weinh)2023
36724072Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation.Cell Rep2023
34699694The Cell-Isolation Capsules with Rod-Like Channels Ensure the Survival and Response of Cancer Cells to Their Microenvironment.Adv Healthc Mater2022
35624341Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer.Nat Cancer2022
36176911Lenvatinib- and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer.Acta Pharm Sin B2022
36162714Prostate cancer treatment - China's perspective.Cancer Lett2022
36008379Zeb1 sustains hematopoietic stem cell functions by suppressing mitofusin-2-mediated mitochondrial fusion.Cell Death Dis2022
32935937Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy.Adv Healthc Mater2021
33655208Single-cell mapper (scMappR): using scRNA-seq to infer the cell-type specificities of differentially expressed genes.NAR Genom Bioinform2021
33741928The transcriptional landscape of Shh medulloblastoma.Nat Commun2021
33782401Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.Nat Commun2021
34580467T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy.Nat Nanotechnol2021
34021647A novel mouse model for liver metastasis of prostate cancer reveals dynamic tumour-immune cell communication.Cell Prolif2021
32461609Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration.Nat Commun2020
31954095Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks.Mol Cell2020
33328604Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer.Commun Biol2020
30467379Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes.Oncogene2019
31350389The histone methyltransferase Setd2 is indispensable for V(D)J recombination.Nat Commun2019
31054182Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells.Cell Prolif2019
30665442Elevated expression of Gab1 promotes breast cancer metastasis by dissociating the PAR complex.J Exp Clin Cancer Res2019
29511594Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing.Am J Cancer Res2018
30118484E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo.PLoS Genet2018
30279728Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɿ/TBK1/NF-κB signaling.Theranostics2018
29440506Carbon Monoxide Impairs CD11b<sup>+</sup>Ly-6C<sup>hi</sup> Monocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis.J Immunol2018
27756792A MicroRNA302-367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability.Circ Res2017
28209613WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT<sup>high</sup> Prostate Cancer Stem Cells.Cancer Res2017
29017577Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway.J Exp Clin Cancer Res2017
28751447Numb<sup>-/low</sup> Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling.Clin Cancer Res2017
28745315miR-302/367/LATS2/YAP pathway is essential for prostate tumor-propagating cells and promotes the development of castration resistance.Oncogene2017
26050620Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition.Oncogene2016
26310200A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis.J Pathol2016
27974211Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.Cell Rep2016
27564589Stox1 as a novel transcriptional suppressor of Math1 during cerebellar granule neurogenesis and medulloblastoma formation.Cell Death Differ2016
26826310Treating leukemia at the risk of inducing severe anemia.Exp Hematol2016
25915733Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.Nat Immunol2015
26544537Quantifying Epithelial Early Common Progenitors from Long-Term Primary or Cell Line Sphere Culture.Curr Protoc Stem Cell Biol2015
26460004Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.Proc Natl Acad Sci U S A2015
26147661Proteomic Comparison and MRM-Based Comparative Analysis of Metabolites Reveal Metabolic Shift in Human Prostate Cancer Cell Lines.J Proteome Res2015
25919994Autonomous assembly of epithelial structures by subrenal implantation of dissociated embryonic inner-ear cells.Neuroreport2015
25163637Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages.Nat Commun2014
25237769TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.Oncotarget2014
24981838Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.Cell Metab2014
25046164TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53.Gastroenterology2014
23269672Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.J Biol Chem2013
24672777Cytokeratin 18 is not required for morphogenesis of developing prostates but contributes to adult prostate regeneration.Biomed Res Int2013
23236157Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase.Proc Natl Acad Sci U S A2013
22431513Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.Mol Cell Biol2012
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Collaborators

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Co-authored papers 13
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Ontario Institute for Cancer Research, University Avenue
Co-authored papers 2
Diala Abd-Rabbo
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Co-authored papers 2
J??ri Reimand
Ontario Institute for Cancer Research
Co-authored papers 2
Michael D Wilson
SickKids Research Institute
Co-authored papers 2
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 1
James M Olson
Clinical Research Division, Fred Hutchinson Cancer Center
Co-authored papers 1
Claudia C Faria
Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte (CHULN)
Co-authored papers 1
Betty Luu
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Franck Bourdeaut
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Toshihiro Kumabe
Kitasato University School of Medicine
Co-authored papers 1
Uri Tabori
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Quang M Trinh
Ontario Institute for Cancer Research
Co-authored papers 1
Pim J French
Erasmus MC Cancer Institute
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Fran??ois Doz
Institut Curie and University Paris Cite
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Jaume Mora
Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu
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George Yancey Gillespie
Heersink School of Medicine, The University of Alabama at Birmingham
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Erwin G Van Meir
Heersink School of Medicine, University of Alabama at Birmingham
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Joanna J Phillips
University of California san francisco
Co-authored papers 1
Hanno Steen
Boston Children's Hospital, USA Harvard Medical School, Harvard Medical School
Co-authored papers 1
Shimin Shuai
Southeast University
Co-authored papers 1
Li-Fan Zeng
Co-authored papers 1
Dong-Er Zhang
Moores Cancer Center, University of California San Diego
Co-authored papers 1
Seung-Ki Kim
Seoul National University Children's Hospital
Co-authored papers 1
William A Weiss
University of California san francisco
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Luyao Ruan
College of Life Sciences, Nanjing Agricultural University
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Release 1.2