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Author Details

Stephan A M??ller
German Center for Neurodegenerative Diseases, Technical University of Munich
2010
52
19
PMIDPaper TitleJournal TitlePublished Year
36745974A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.EBioMedicine2023
37596282Reactivated endogenous retroviruses promote protein aggregate spreading.Nat Commun2023
37388246Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics.Front Mol Biosci2023
37430025Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions.Nat Metab2023
36810097The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.Mol Neurodegener2023
34958451The β-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice.Mol Neurobiol2022
35736286Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State.Membranes (Basel)2022
35666874Signatures of glial activity can be detected in the CSF proteome.Proc Natl Acad Sci U S A2022
35688487LncRNA <i>RUS</i> shapes the gene expression program towards neurogenesis.Life Sci Alliance2022
36443293Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae.Nat Commun2022
36611872Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.Cells2022
36470941Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.Sci Rep2022
36563667Spatial proteomics in three-dimensional intact specimens.Cell2022
35074002Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.Acta Neuropathol Commun2022
32951307Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome.Proteomics2021
33627648Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.Nat Commun2021
33785583ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.J Am Soc Nephrol2021
33673623Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates.Int J Mol Sci2021
34706241Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery.Cell Rep2021
34380771The <i>Uppsala APP</i> deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.Sci Transl Med2021
34613632The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.FASEB J2021
34667166Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions.Nat Commun2021
32195080Fibroblast Growth Factor 2-Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons.Adv Sci (Weinh)2020
31908000Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.FASEB J2020
32078678Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis.J Exp Med2020
33101391FGF2 Affects Parkinson's Disease-Associated Molecular Networks Through Exosomal Rab8b/Rab31.Front Genet2020
32707433Basic Fibroblast Growth Factor 2-Induced Proteome Changes Endorse Lewy Body Pathology in Hippocampal Neurons.iScience2020
32954517An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome.EMBO J2020
32567721Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.EMBO J2020
30617257Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.Nat Neurosci2019
31501572Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.Nat Neurosci2019
31266883Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells.Life Sci Alliance2019
30833305NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.EMBO Mol Med2019
31061204Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.EMBO Rep2019
30733281Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.EMBO Rep2019
30733280The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.EMBO Rep2019
29716987Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome.Mol Cell Proteomics2018
30279425Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor.Sci Rep2018
29725820CADASIL brain vessels show a HTRA1 loss-of-function profile.Acta Neuropathol2018
29414760Proteome Data Improves Protein Function Prediction in the Interactome of <i>Helicobacter pylori</i>.Mol Cell Proteomics2018
27476612Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.Matrix Biol2017
27991726An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.Proteomics2017
27716410Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.Mol Neurodegener2016
27790089Proteomic Substrate Identification for Membrane Proteases in the Brain.Front Mol Neurosci2016
25348772Integration of conventional quantitative and phospho-proteomics reveals new elements in activated Jurkat T-cell receptor pathway maintenance.Proteomics2015
26553928Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.J Cell Biol2015
26139848Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.Mol Cell Proteomics2015
25979772Stable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori.J Proteomics2015
23665149Identification of new protein coding sequences and signal peptidase cleavage sites of Helicobacter pylori strain 26695 by proteogenomics.J Proteomics2013
22990618Quantitative proteomics reveals altered expression of extracellular matrix related proteins of human primary dermal fibroblasts in response to sulfated hyaluronan and collagen applied as artificial extracellular matrix.J Mater Sci Mater Med2012
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Collaborators

Institute for Bioanalysis, Coburg University of Applied Sciences and Arts
Co-authored papers 6
Co-authored papers 3
Institute of Developmental Genetics, German Research Center for Environmental Health
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Center for the Study of Biological Complexity, Virginia Commonwealth University
Co-authored papers 2
Co-authored papers 2
German Center for Neurodegenerative Diseases (DZNE) Munich
Co-authored papers 2
Institute of Biological Information Processing (Structural Biochemistry)
Co-authored papers 1
TUM School of Medicine, Technical University of Munich
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Justus Liebig University Giessen
Co-authored papers 1
American Heart Association, American Society for Microbiology, International Society for Computational Biology, Lawrence Berkeley National Laboratory, University of California Los Angeles, University of Delaware, Virginia Commonwealth University
Co-authored papers 1
Emory University School of Medicine
Co-authored papers 1
Massachusetts Institute of Technology
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Nara Institute of Science and Technology
Co-authored papers 1
Institute of Bioengineering of Catalonia (IBEC)
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Max-Planck Institute of Biochemistry
Co-authored papers 1
University of Miami
Co-authored papers 1
Institute of Physical Biology, Heinrich Heine University Dusseldorf
Co-authored papers 1
Institucio Catalana de Recerca i Estudis Avancats (ICREA)
Co-authored papers 1
Technical University of Munich
Co-authored papers 1
Co-authored papers 1
SSSSGerman Cancer Research Center
Co-authored papers 1
Co-authored papers 1