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Author Details

John C Schimenti
1983
194
56
PMIDPaper TitleJournal TitlePublished Year
37073822Female infertility from oocyte maturation arrest: assembling the genetic puzzle.2023
37801077New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility.2023
37884859Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model.BMC Genomics2023
37413663Practical strategies for robust and inexpensive imaging of aqueous-cleared tissues.2023
35123146Bone mass and adaptation to mechanical loading are sexually dimorphic in adult osteoblast-specific ERα knockout mice.2022
36289231Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.Nature Communications2022
35977408Genome Maintenance in Mammalian Stem Cells.Annual Review of Genetics2022
34358805Genome maintenance during embryogenesis.2021
33722289Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression.Genome Biol2021
33057575Conditional surrender in one generation: determining the reproductive roles of mouse embryo lethal genes by embryo complementation.Biology of Reproduction2021
33431240Strategies to Identify Genetic Variants Causing Infertility.Trends in Molecular Medicine2021
34408140Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.Nat Commun2021
33075054A novel function for CDK2 activity at meiotic crossover sites.PLoS Biology2020
31901081Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5CD44 cells.Nature Communications2020
31940063Copy-number variation introduced by long transgenes compromises mouse male fertility independently of pachytene checkpoints.Chromosoma2020
32343484A reporter mouse for in vivo detection of DNA damage in embryonic germ cells.Genesis2020
32493750Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (<i>WT1</i>) gene.Proc Natl Acad Sci U S A2020
32273296Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63.Genetics2020
32272448Meiotic epigenetic factor PRDM9 impacts sperm quality of hybrid mice.Reproduction2020
32877668Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation.Cell Reports2020
33184219Sexually dimorphic DNA damage responses and mutation avoidance in the mouse germline.Genes and Development2020
33075816Variants in RABL2A causing male infertility and ciliopathy.Hum Mol Genet2020
31393579A predicted deleterious allele of the essential meiosis gene MND1, present in ~â¿¿3% of East Asians, does not disrupt reproduction in mice.Molecular Human Reproduction2019
31582414CDK2 kinase activity is a regulator of male germ cell fate.Development (Cambridge)2019
31074776A segregating human allele of SPO11 modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserveâ¿ .Biology of Reproduction2019
31119900Germline genome protection: implications for gamete quality and germ cell tumorigenesis.Andrology2019
30734403ENU-induced mutant allele of Dnah1, ferf1, causes abnormal sperm behavior and fertilization failure in mice.Molecular Reproduction and Development2019
30787433Female-biased embryonic death from inflammation induced by genomic instability.Nature2019
31515488Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.Nat Commun2019
29782020Whole Mount Immunofluorescence and Follicle Quantification of Cultured Mouse Ovaries.Journal of Visualized Experiments2018
29878059Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".Biology of Reproduction2018
30085085A putative human infertility allele of the meiotic recombinase DMC1 does not affect fertility in mice.Human Molecular Genetics2018
27986806Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog.Genetics2017
28844861The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.Molecular Cell2017
28576861Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death.Genetics2017
26765334Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation.PLoS Genet2016
26876048Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression.2016
27280691The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.Genetics2016
26953264L. C. Dunn and Donald Charles on Quantitative Traits in the Mouse.Genetics2016
26240362The genetics of human infertility by functional interrogation of SNPs in mice.Proceedings of the National Academy of Sciences of the United States of America2015
25707500Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice.Journal of Bone and Mineral Research2015
25547156Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.Journal of Cell Biology2015
25795304MEI4 â¿¿ a central player in the regulation of meiotic DNA double-strand break formation in the mouse.Journal of Cell Science2015
25271304A mouse geneticist's practical guide to CRISPR applications.Genetics2015
25892231Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.Cell Reports2015
26388201MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.Genesis2015
25073031A method for isolating high quality RNA from mouse cortical and cancellous bone.2014
28934603Applying "Gold Standards" to In-Vitro-Derived Germ Cells.Cell2014
24362311IQ motif-containing G (Iqcg) is required for mouse spermiogenesis.G3: Genes, Genomes, Genetics2014
24038209Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength.Journal of Bone and Mineral Research2014
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North Carolina State University, USA Center for Human Health and the Environment
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Tufts University Graduate School of Biomedical Sciences
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Weill Institute for Cell and Molecular Biology, Cornell University
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University of Michigan ann arbor
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University of Massachusetts Medical School
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German Center for Neurodegenerative Diseases (DZNE).
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Wellcome Trust Sanger Institute
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IDR/Westmead Institute for Medical Research
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Lawrence Berkeley National Laboratory
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Ottawa Hospital Research Institute
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HudsonAlpha Institute for Biotechnology, Stanford University
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