|
| 35021603 | Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade. | Haematologica | 2023 |
| 37863876 | A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. | Nat Commun | 2023 |
| 37587144 | Pharmacological perturbation of the phase-separating protein SMNDC1. | Nat Commun | 2023 |
| 37516113 | Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors. | Cell Chem Biol | 2023 |
| 36602777 | E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. | J Am Chem Soc | 2023 |
| 36152767 | Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis. | J Hepatol | 2023 |
| 33982887 | Therapeutic targeting of chromatin: status and opportunities. | FEBS J | 2022 |
| 35393162 | Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound. | Eur Urol | 2022 |
| 36513079 | Metabolic modulation of transcription: The role of one-carbon metabolism. | Cell Chem Biol | 2022 |
| 36044849 | SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression. | Cell Rep | 2022 |
| 35994477 | A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation. | PLoS Genet | 2022 |
| 34635570 | Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders. | Cancer Discov | 2022 |
| 33202418 | Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor. | Blood | 2021 |
| 35607664 | PlateFlo - A software-controllable plate-scale perfusion system for culture of adherent cells. | HardwareX | 2021 |
| 33626863 | Rationale for the combination of venetoclax and ibrutinib in T-prolymphocytic leukemia. | Haematologica | 2021 |
| 33623882 | Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions. | Hemasphere | 2021 |
| 33558760 | Acute BAF perturbation causes immediate changes in chromatin accessibility. | Nat Genet | 2021 |
| 33662183 | Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives. | ChemSusChem | 2021 |
| 33855809 | Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives. | ChemSusChem | 2021 |
| 35211674 | Target 2035 - update on the quest for a probe for every protein. | RSC Med Chem | 2021 |
| 34433968 | APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. | Nature | 2021 |
| 34454092 | An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation. | Mol Metab | 2021 |
| 34478517 | Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma. | Blood Adv | 2021 |
| 34333533 | High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells. | Blood Cancer J | 2021 |
| 33972798 | Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. | Nat Metab | 2021 |
| 33452497 | Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling. | Nat Chem Biol | 2021 |
| 33241558 | 5-Arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones with selective inhibitory activity against some leukemia cell lines. | Arch Pharm (Weinheim) | 2021 |
| 33323974 | STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway. | Oncogene | 2021 |
| 31123029 | High activation of STAT5A drives peripheral T-cell lymphoma and leukemia. | Haematologica | 2020 |
| 33203764 | Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time. | Genome Res | 2020 |
| 32747809 | Rational discovery of molecular glue degraders via scalable chemical profiling. | Nat Chem Biol | 2020 |
| 32375897 | Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets. | Genome Biol | 2020 |
| 30692684 | Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL. | Nat Chem Biol | 2019 |
| 31723137 | Mapping the perturbome network of cellular perturbations. | Nat Commun | 2019 |
| 31436963 | A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants. | J Am Chem Soc | 2019 |
| 31292114 | Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia. | Blood | 2019 |
| 31427792 | Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. | Nat Genet | 2019 |
| 31628323 | A kinase-independent role for CDK8 in BCR-ABL1<sup>+</sup> leukemia. | Nat Commun | 2019 |
| 31133746 | MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. | Nat Genet | 2019 |
| 29200404 | STAT5BN642H is a driver mutation for T cell neoplasia. | J Clin Invest | 2018 |
| 29899063 | CDK6 Antagonizes p53-Induced Responses during Tumorigenesis. | Cancer Discov | 2018 |
| 30520733 | Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists. | Elife | 2018 |
| 29472718 | Pharmacologic inhibition of STAT5 in acute myeloid leukemia. | Leukemia | 2018 |
| 27916275 | Artemisinins Target GABA<sub>A</sub> Receptor Signaling and Impair α Cell Identity. | Cell | 2017 |
| 34541110 | Generation of a Cellular Reporter for Functional BRD4 Inhibition. | Bio Protoc | 2017 |
| 28437395 | Global survey of the immunomodulatory potential of common drugs. | Nat Chem Biol | 2017 |
| 28255017 | Cdk6 contributes to cytoskeletal stability in erythroid cells. | Haematologica | 2017 |
| 28416739 | TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML. | Oncotarget | 2017 |
| 29153976 | Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study. | Lancet Haematol | 2017 |
| 29149600 | Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. | Mol Cell | 2017 |