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Author Details

Lyle D Burgoon
National Center for Environmental Assessment
2004
85
29
PMIDPaper TitleJournal TitlePublished Year
38059960Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene.Arch Toxicol2024
36494002Understanding and overcoming the technical challenges in using in silico predictions in regulatory decisions of complex toxicological endpoints - A pesticide perspective for regulatory toxicologists with a focus on machine learning models.Regul Toxicol Pharmacol2023
35103817A novel approach to calculating the kinetically derived maximum dose.Arch Toxicol2022
35507340Comment on "Application of an <i>in Vitro</i> Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors".Environ Health Perspect2022
34333066Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology.Regul Toxicol Pharmacol2021
34623454Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety.Arch Toxicol2021
32388890Assessment of Transcriptomic and Apical Responses of Daphnia magna Exposed to a Polyethylene Microplastic in a 21-d Chronic Study.Environ Toxicol Chem2020
31721239Predicting the Probability that a Chemical Causes Steatosis Using Adverse Outcome Pathway Bayesian Networks (AOPBNs).Risk Anal2020
33369481Community Approaches for Integrating Environmental Exposures into Human Models of Disease.Environ Health Perspect2020
32986269Evaluation of the Inherent Toxicity Concept in Environmental Toxicology and Risk Assessment.Environ Toxicol Chem2020
32217427Organizing mechanism-related information on chemical interactions using a framework based on the aggregate exposure and adverse outcome pathways.Environ Int2020
30332685Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways.ALTEX2019
31486145Different as night and day: Behavioural and life history responses to varied photoperiods in Daphnia magna.Mol Ecol2019
31074622Development of Adverse Outcome Pathway for PPARγ Antagonism Leading to Pulmonary Fibrosis and Chemical Selection for Its Validation: ToxCast Database and a Deep Learning Artificial Neural Network Model-Based Approach.Chem Res Toxicol2019
31127958Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment.Environ Toxicol Chem2019
29383852Building a developmental toxicity ontology.Birth Defects Res2018
30622555Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials.Front Genet2018
27088631Using In Vitro High-Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards.Risk Anal2017
27666475A decision analysis framework for estimating the potential hazards for drinking water resources of chemicals used in hydraulic fracturing fluids.Sci Total Environ2017
26011822Applying comprehensive environmental assessment to research planning for multiwalled carbon nanotubes: Refinements to inform future stakeholder engagement.Integr Environ Assess Manag2016
27717971Response to Cohen et al. (2016) regarding response to Druwe and Burgoon.Arch Toxicol2016
27172125Estimating the Potential Toxicity of Chemicals Associated with Hydraulic Fracturing Operations Using Quantitative Structure-Activity Relationship Modeling.Environ Sci Technol2016
27325233Revisiting Cohen et al. 2015, Cohen et al. 2014 and Waalkes et al. 2014: a bayesian re-analysis of tumor incidences.Arch Toxicol2016
27091369The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.Environ Health Perspect2016
27091326A Market-Basket Approach to Predict the Acute Aquatic Toxicity of Munitions and Energetic Materials.Bull Environ Contam Toxicol2016
27050380Overview of Chronic Oral Toxicity Values for Chemicals Present in Hydraulic Fracturing Fluids, Flowback, and Produced Waters.Environ Sci Technol2016
25875676Can data science inform environmental justice and community risk screening for type 2 diabetes?PLoS One2015
26500288Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence.Toxicol Sci2015
26422241Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.PLoS One2015
26132979Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting.J Occup Environ Hyg2015
24325902Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.Neurotoxicology2014
25531884Systematic Omics Analysis Review (SOAR) tool to support risk assessment.PLoS One2014
24727499A framework for the next generation of risk science.Environ Health Perspect2014
24327299What do the data show? Knowledge map development for comprehensive environmental assessment.Integr Environ Assess Manag2014
23811191PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons.J Steroid Biochem Mol Biol2013
24177217Molecular target sequence similarity as a basis for species extrapolation to assess the ecological risk of chemicals with known modes of action.Aquat Toxicol2013
21964420Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver.Toxicol Sci2012
22227403A graphical systems model and tissue-specific functional gene sets to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis.Mutat Res2012
22244038MIPHENO: data normalization for high throughput metabolite analysis.BMC Bioinformatics2012
22383539Plastids are major regulators of light signaling in Arabidopsis.Plant Physiol2012
20880076Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis.Liver Int2011
21797767Pulmonary inflammatory and fibrotic responses in Fischer 344 rats after intratracheal instillation exposure to Libby amphibole.J Toxicol Environ Health A2011
21851831Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice.Toxicol Appl Pharmacol2011
21370876Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes.Chem Res Toxicol2011
21496263Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells.BMC Genomics2011
20079471Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells.Biochim Biophys Acta2010
20702594Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.Toxicol Sci2010
20628019Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice.J Mol Endocrinol2010
20371263Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment.Toxicology2010
20399798Effects of TCDD on the expression of nuclear encoded mitochondrial genes.Toxicol Appl Pharmacol2010
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Collaborators

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University of Ottawa
Co-authored papers 2
Center for Public Health and Environmental Assessment
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Co-authored papers 1
North Carolina State University
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University of Minnesota
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University of Cape Town
Co-authored papers 1
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National University of Singapore
Co-authored papers 1
Columbia University
Co-authored papers 1
Biodiversity Information Standards, Coastal and Estuarine Research Federation, Oregon State University, Phycological Society of America, Society of Professional Consultants, The Data Detektiv, University of Colorado Anschutz Medical Campus, University of Maryland College Park, Women in the Enterprise of Science and Technology
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Oregon State University
Co-authored papers 1
Oregon State University, College of Public Health and Human Sciences
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Center for the Study of Biological Complexity, Virginia Commonwealth University
Co-authored papers 1
Washington University School of Medicine
Co-authored papers 1
Joint Research Centre (JRC)
Co-authored papers 1
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European Bioinformatics Institute
Co-authored papers 1
National Institute of Environmental Health Sciences
Co-authored papers 1
School of Public Health, Boston University
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