Author details

Full Name

Scot A Wolfe

Affiliation

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38033325	Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.	Nucleic Acids Res	2024
37292647	Gene editing without <i>ex vivo</i> culture evades genotoxicity in human hematopoietic stem cells.	bioRxiv	2023
37756546	Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice.	Blood Adv	2023
37745491	A brown fat-enriched adipokine, ASRA, is a leptin receptor antagonist that stimulates appetite.		2023
37904991	Addressing the dNTP bottleneck restricting prime editing activity.		2023
37633272	Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish.		2023
36522432	Human genetic diversity alters off-target outcomes of therapeutic gene editing.		2023
37156841	Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.		2023
37273902	Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation.		2023
37382276	Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis.	EMBO J	2023
37246708	Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency.		2023
36993169	Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing <i>in vivo</i>.	bioRxiv	2023
37482187	Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming.		2023
34998953	A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver.	Molecular Therapy	2022
35945271	Functional restoration of mouse Nf1 nonsense alleles in differentiated cultured neurons.	Journal of Human Genetics	2022
35811581	Adenine Base Editing with a Single Adeno-Associated Virus Vector.		2022
36070530	Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors.	CRISPR Journal	2022
35064134	Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.	Nat Commun	2022
35165413	LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.	Nat Cell Biol	2022
34376056	Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities.	Human Gene Therapy	2022
34836963	CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.	Nature Communications	2021
33859416	ZNF410 represses fetal globin by singular control of CHD4.	Nature Genetics	2021
33837189	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.	Nature Communications	2021
33513358	Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.	Cell Stem Cell	2021
33828315	The NIH Somatic Cell Genome Editing program.	Nature	2021
34725353	Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.	Nature Communications	2021
32897878	BCL11A enhancer-edited hematopoietic stem cells persist in rhesus monkeys without toxicity.	J Clin Invest	2020
30883196	Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases.	Annu Rev Biochem	2019
31698466	Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.	Blood Adv	2019
31564611	Valves Are a Conserved Feature of the Zebrafish Lymphatic System.	Developmental Cell	2019
30704988	Editing aberrant splice sites efficiently restores Î²-globin expression in Î²-thalassemia.	Blood	2019
30911135	Highly efficient therapeutic gene editing of human hematopoietic stem cells.	Nat Med	2019
31253978	Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.	Nat Genet	2019
30892626	Enhanced Cas12a editing in mammalian cells and zebrafish.	Nucleic Acids Research	2019
30944467	Precise therapeutic gene correction by a simple nuclease-induced double-stranded break.	Nature	2019
29735996	C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.	Nat Methods	2018
30455303	SIR proteins create compact heterochromatin fibers.	Proceedings of the National Academy of Sciences of the United States of America	2018
30451839	Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.	Nature Communications	2018
30142347	CBFÎ²-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.	Cell	2018
29958106	CBFÎ²-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.	Cell	2018
30531933	Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.	Nature Communications	2018
30518407	NmeCas9 is an intrinsically high-fidelity genome-editing platform.		2018
29298290	motifStack for the analysis of transcription factor binding site evolution.	Nature Methods	2018
29377001	Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.	Nature Chemical Biology	2018
29078326	CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.	Proc Natl Acad Sci U S A	2017
28863194	Correction: The Dkk3 gene encodes a vital intracellular regulator of cell proliferation.	PLoS ONE	2017
28506212	GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases.	BMC Genomics	2017
28738084	The Dkk3 gene encodes a vital intracellular regulator of cell proliferation.	PLoS ONE	2017
29131148	Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.	Nature Biotechnology	2017
26716561	Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery.	Nature Methods	2016