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Author Details

Udo Heinemann
Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC)
1980
205
53
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36656859Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.Proc Natl Acad Sci U S A2023
37905925Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.J Med Chem2023
38049725Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks.BMC Genomics2023
37068239TapA acts as specific chaperone in TasA filament formation by strand complementation.Proc Natl Acad Sci U S A2023
35921615Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.J Med Chem2022
33450228Pantoea stewartii WceF is a glycan biofilm-modifying enzyme with a bacteriophage tailspike-like fold.J Biol Chem2021
37904770Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.Magn Reson (Gott)2021
34555281Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer.J Med Chem2021
33950203PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.Nucleic Acids Res2021
33430354Cold-Shock Domains-Abundance, Structure, Properties, and Nucleic-Acid Binding.Cancers (Basel)2021
32473201Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi.J Struct Biol2020
31862141Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae.Biochem Biophys Res Commun2020
33184177Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.Proc Natl Acad Sci U S A2020
33210922From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.J Med Chem2020
31475772Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases.ChemMedChem2019
31795346Structural Features of Tight-Junction Proteins.Int J Mol Sci2019
31648844Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1.Structure2019
31189652Time-resolved DNA release from an O-antigen-specific <i>Salmonella</i> bacteriophage with a contractile tail.J Biol Chem2019
29122970A novel form of RNA double helix based on G·U and C·A<sup>+</sup> wobble base pairing.RNA2018
30044908Solvent Networks Tune Thermodynamics of Oligosaccharide Complex Formation in an Extended Protein Binding Site.J Am Chem Soc2018
29531041Structural changes of TasA in biofilm formation of <i>Bacillus subtilis</i>.Proc Natl Acad Sci U S A2018
29309642Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.Nucleic Acids Res2018
28661558Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.Ann N Y Acad Sci2017
28436082Tricellulin is a target of the ubiquitin ligase Itch.Ann N Y Acad Sci2017
28221042Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins.J Phys Chem Lett2017
28346812Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.SLAS Discov2017
28740983Combining EPR spectroscopy and X-ray crystallography to elucidate the structure and dynamics of conformationally constrained spin labels in T4 lysozyme single crystals.Phys Chem Chem Phys2017
27102985AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.Biochem J2016
27673570Tracking Transient Conformational States of T4 Lysozyme at Room Temperature Combining X-ray Crystallography and Site-Directed Spin Labeling.J Am Chem Soc2016
27762274Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.Nat Commun2016
27131901Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.Biochim Biophys Acta2016
27045683Bacteriophage Tailspikes and Bacterial O-Antigens as a Model System to Study Weak-Affinity Protein-Polysaccharide Interactions.J Am Chem Soc2016
25877780Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells inâ¿¿vitro and inâ¿¿vivo.ChemMedChem2015
26170170RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.Nat Commun2015
24961828Crystal structure of the yeast TRAPP-associated protein Tca17.FEBS J2014
25504471Roquin binding to target mRNAs involves a winged helix-turn-helix motif.Nat Commun2014
25324549Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function.J Biol Chem2014
24816102Bacteriophage P22 tailspike: structure of the complete protein and function of the interdomain linker.Acta Crystallogr D Biol Crystallogr2014
22923442Single amino acid exchange in bacteriophage HK620 tailspike protein results in thousand-fold increase of its oligosaccharide affinity.Glycobiology2013
23939427Mechanisms of Lin28-mediated miRNA and mRNA regulation--a structural and functional perspective.Int J Mol Sci2013
23770886Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.RNA Biol2013
23292517An essential serotype recognition pocket on phage P22 tailspike protein forces Salmonella enterica serovar Paratyphi A O-antigen fragments to bind as nonsolution conformers.Glycobiology2013
22128343RNA single strands bind to a conserved surface of the major cold shock protein in crystals and solution.RNA2012
22781308Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.Circ Cardiovasc Genet2012
22820093Peptide linkage to the α-subunit of MHCII creates a stably inverted antigen presentation complex.J Mol Biol2012
22570413The Lin28 cold-shock domain remodels pre-let-7 microRNA.Nucleic Acids Res2012
22262864Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex.J Biol Chem2012
22364412Tail morphology controls DNA release in two Salmonella phages with one lipopolysaccharide receptor recognition system.Mol Microbiol2012
22157815The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.EMBO J2012
21290164The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation.Cell Mol Life Sci2011
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Collaborators

Konrad B??ssow
Helmholtz Centre for Infection Research
Co-authored papers 12
Hartmut Oschkinat
Leibniz-Forschungsinstitut fur Molekulare Pharmakologie
Co-authored papers 11
Klaas E A Max
Co-authored papers 9
Anja Sch??tz
Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 7
Joel L Sussman
Weizmann Institute of Science
Co-authored papers 6
Yoav Peleg
Weizmann Institute of Science
Co-authored papers 3
Raymond J Owens
University of Oxford
Co-authored papers 3
Stephen K Burley
The State University of New Jersey
Co-authored papers 2
David I Stuart
University of Oxford
Co-authored papers 2
Sebastian Günther
Co-authored papers 2
Wolfgang Baumeister
Max Planck Institute of Biochemistry
Co-authored papers 2
Masayori Inouye
Robert Wood Johnson Medical School, Rutgers University
Co-authored papers 2
Bernd Reif
Technische Universitat Munchen (TUM)
Co-authored papers 2
Rong Xiao
School of Public Health, Capital Medical University
Co-authored papers 1
Erik McShane
Blavatnik Institute, Harvard Medical School
Co-authored papers 1
Sirano Dhe-Paganon
Dana-Farber Cancer Institute
Co-authored papers 1
Mei Jiang
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Kristin C Gunsalus
Center for Genomics and Systems Biology, New York University Abu Dhabi (NYUAD)
Co-authored papers 1
Gaetano T Montelione
Rensselaer Polytechnic Institute
Co-authored papers 1
Ritu Shastry
Co-authored papers 1
Opher Gileadi
Structural Genomics Consortium Karolinska Institute Stockholm Sweden.
Co-authored papers 1
Zihe Rao
Nankai University
Co-authored papers 1
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 1
Kellie Cunningham
Co-authored papers 1
F W Studier
Brookhaven National Laboratory
Co-authored papers 1
Caroline C Friedel
Institute of Informatics, Ludwig-Maximilians-Universitat Munchen
Co-authored papers 1
Peer Bork
University of Wurzburg
Co-authored papers 1
P??r Nordlund
Karolinska Institutet, BioClinicum J6
Co-authored papers 1
Geoffrey S Waldo
Los Alamos National Laboratory
Co-authored papers 1
Yunyu Shi
University of Science & Technology of China
Co-authored papers 1
Release 1.2