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Author Details

Jacob D Estes
Vaccine and Gene Therapy Institute, Oregon Health & Science University
2002
190
64
Sarah J Ratcliffe (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36807684In-depth virological and immunological characterization of HIV-1 cure after CCR5ο32/ο32 allogeneic hematopoietic stem cell transplantation.Nat Med2023
37506197Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.Sci Immunol2023
37493435Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV.Ann Neurol2023
36989320Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques.PLoS Pathog2023
37418480Correction: Tracking the Luminal Exposure and Lymphatic Drainage Pathways of Intravaginal and Intrarectal Inocula Used in Nonhuman Primate Models of HIV Transmission.PLoS One2023
37075022Correction: Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.PLoS Pathog2023
37236188Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques.Immunity2023
37223960Lymph-Node-Based CD3<sup>+</sup> CD20<sup>+</sup> Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection.J Virol2023
36813761Prolonged experimental CD4<sup>+</sup> T-cell depletion does not cause disease progression in SIV-infected African green monkeys.Nat Commun2023
35104248IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health.JCI Insight2022
35441468Antiretroviral drug exposure in lymph nodes is heterogeneous and drug dependent.J Int AIDS Soc2022
35856680Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates.Antimicrob Agents Chemother2022
35395058Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques.PLoS Pathog2022
35714200Myeloid cell tropism enables MHC-E-restricted CD8<sup>+</sup> T cell priming and vaccine efficacy by the RhCMV/SIV vaccine.Sci Immunol2022
35447093Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments.Immunity2022
36146803Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders.Viruses2022
35867351Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART.Ann Neurol2022
36130503An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission.Cell Rep2022
36122933Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia.J Immunol2022
34985671In Situ Multiplexing to Identify, Quantify, and Phenotype the HIV-1/SIV Reservoir Within Lymphoid Tissue.Methods Mol Biol2022
35316218Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.J Clin Invest2022
35012348Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity.mBio2022
35176661Evidence of cancer therapy-induced chronic inflammation in the ovary across multiple species: A potential cause of persistent tissue damage and follicle depletion.J Reprod Immunol2022
35230978Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.J Clin Invest2022
34863818Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue.J Immunol Methods2022
32939636Feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients.Abdom Radiol (NY)2021
33711270TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma.Cell Host Microbe2021
33536176Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity <i>Ex Vivo and In Vivo</i>.J Virol2021
33782003Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Collagen in the Mesenteric Lymph Nodes of Nonhuman Primates.Antimicrob Agents Chemother2021
33630764CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification.J Clin Invest2021
34888397A Randomized, Placebo-Controlled Trial Assessing the Effect of VISBIOME ES Probiotic in People With HIV on Antiretroviral Therapy.Open Forum Infect Dis2021
34589750The role of oxidative stress in HIV-associated neurocognitive disorders.Brain Behav Immun Health2021
34181694Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.PLoS Pathog2021
34039843Eliminating HIV reservoirs for a cure: the issue is in the tissue.Curr Opin HIV AIDS2021
34295327Adjacent Cell Marker Lateral Spillover Compensation and Reinforcement for Multiplexed Images.Front Immunol2021
33970966Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.PLoS Pathog2021
33465055Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.J Clin Invest2021
33278358Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.Cell2021
32163523The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques.PLoS Pathog2020
32066947HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells.Nat Immunol2020
33065030Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques.Cell2020
32884153Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.Nat Med2020
32995780Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.bioRxiv2020
32881968Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.PLoS Pathog2020
32628155Next-generation Viral RNA/DNA in situ Hybridization Applications in Human Immunodeficiency Virus/Simian Immunodeficiency Virus Research.J Vis Exp2020
32898182Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection.PLoS Pathog2020
32895573Recommendations for measuring HIV reservoir size in cure-directed clinical trials.Nat Med2020
32841040Application of a Scavenger Receptor A1-Targeted Polymeric Prodrug Platform for Lymphatic Drug Delivery in HIV.Mol Pharm2020
32284611CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption.Nat Med2020
32119719African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity.PLoS Pathog2020
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Collaborators

Frederick National Laboratory
Co-authored papers 54
Co-authored papers 35
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 30
Vaccine & Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 15
Co-authored papers 13
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Co-authored papers 11
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 11
Pathology Advanced Translational Research Unit, Emory University School of Medicine
Co-authored papers 8
University of California san francisco
Co-authored papers 8
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Co-authored papers 7
Rollins School of Public Health, Emory University School of Medicine
Co-authored papers 7
The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
Co-authored papers 6
Co-authored papers 6
Co-authored papers 5
The Rockefeller University
Co-authored papers 5
Vaccine & Gene Therapy Institute, and Oregon National Primate Research Center
Co-authored papers 5
Co-authored papers 4
Merck & Co. Inc.
Co-authored papers 4
Co-authored papers 4
The Rockefeller University
Co-authored papers 4
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National Cancer Institute, National Institutes of Health
Co-authored papers 4
Co-authored papers 4
University of Washington
Co-authored papers 3
Co-authored papers 3
Center for Interventional Oncology, National Institutes of Health
Co-authored papers 3
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Vaccine and Gene Therapy Institute and.
Co-authored papers 3
Oregon Health and Science University
Co-authored papers 3