Author details

Full Name

Heidi E Hamm

Affiliation

ORCID

Career Start Year

1980

Papers

219

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37206665	SNAP25 differentially contributes to G-coupled receptor function at glutamatergic synapses in the nucleus accumbens.		2023
37561580	GÎ²Î³-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity.		2023
35045279	Presynaptic mechanisms underlying GABA-receptor-mediated inhibition of spontaneous neurotransmitter release.	Cell Reports	2022
36590910	Effects of cell size and bicarbonate on single photon response variability in retinal rods.		2022
36710929	Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.		2022
34932372	Specificities of GÎ²Î³ subunits for the SNARE complex before and after stimulation of Î±-adrenergic receptors.	Science Signaling	2021
34855359	Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors.	ACS Chem Neurosci	2021
34710119	Phototransduction in retinal cones: Analysis of parameter importance.	PLoS ONE	2021
31477818	Physiological roles for neuromodulation via G GPCRs working through GÎ²Î³-SNARE interaction.		2020
32060295	Author Correction: The in vivo specificity of synaptic GÎ² and GÎ³ subunits to the Î± adrenergic receptor at CNS synapses.	Scientific Reports	2020
32449556	Sexual Dimorphism in Stress-induced Hyperthermia in SNAP25Î¿3 mice, a mouse model with disabled GÎ²Î³ regulation of the exocytotic fusion apparatus.	European Journal of Neuroscience	2020
33033174	Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study.	Mol Cancer Ther	2020
33052986	Position of rhodopsin photoisomerization on the disk surface confers variability to the rising phase of the single photon response in vertebrate rod photoreceptors.	PLoS ONE	2020
30710014	The expanding roles and mechanisms of G protein-mediated presynaptic inhibition.	Journal of Biological Chemistry	2019
31578230	Heterosynaptic GABA Receptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core.	Journal of Neuroscience	2019
31805112	Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods.	PLoS ONE	2019
30560697	Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.	Platelets	2019
30462538	The role of coagulation and platelets in colon cancer-associated thrombosis.	Am J Physiol Cell Physiol	2019
29752624	GÎ²Î³ SNARE Interactions and Their Behavioral Effects.	Neurochemical Research	2019
31095110	Disabling GÎ²Î³-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus.	NeuroReport	2019
30737458	The in vivo specificity of synaptic GÎ² and GÎ³ subunits to the Î± adrenergic receptor at CNS synapses.	Scientific Reports	2019
30783011	Disabling the GÎ²Î³-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.	Science Signaling	2019
29632174	GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.	Proceedings of the National Academy of Sciences of the United States of America	2018
30056056	GPCR regulation of secretion.	Pharmacology and Therapeutics	2018
29387686	Improved <i>in Vitro</i> Folding of the Y<sub>2</sub> G Protein-Coupled Receptor into Bicelles.	Front Mol Biosci	2018
29436493	G Protein Preassembly Rescues Efficacy of W Toggle Mutations in Neuropeptide Y Receptor.	Molecular Pharmacology	2018
29642851	Tracing the evolution of the heterotrimeric G protein Î± subunit in Metazoa.	BMC Evol Biol	2018
27784794	Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.	Molecular Pharmacology	2017
28880079	Quantitative Multiple-Reaction Monitoring Proteomic Analysis of GÎ² and GÎ³ Subunits in C57Bl6/J Brain Synaptosomes.	Biochemistry	2017
28363980	A Presynaptic Group III mGluR Recruits GÎ²Î³/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.	Journal of Neuroscience	2017
28515322	GÎ²Î³ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.	J Biol Chem	2017
27777004	Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.	Bioorganic and Medicinal Chemistry Letters	2016
27422820	Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein Î±IIbÎ²3 Activation through Dysregulation of the 5-HT2A Receptor.	Journal of Biological Chemistry	2016
27162327	Collybolide is a novel biased agonist of Îº-opioid receptors with potent antipruritic activity.	Proceedings of the National Academy of Sciences of the United States of America	2016
27482618	Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against Î³-Thrombin.	Journal of Medicinal Chemistry	2016
27462082	A Conserved Hydrophobic Core in GÎ±i1 Regulates G Protein Activation and Release from Activated Receptor.	J Biol Chem	2016
26519224	GÎ²Î³ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein-Coupled Receptors.	Molecular Pharmacology	2016
26446588	Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention.	J Thromb Thrombolysis	2016
26295742	Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2Î± Activity and Its Role in Human Platelet Activation.	Biochemistry	2015
25697517	Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles.	Methods in Molecular Biology	2015
25859957	Using peptide arrays created by the SPOT method for defining protein-protein interactions.	Methods in Molecular Biology	2015
24596087	A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in GÎ±i1.	J Biol Chem	2014
25307422	The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.	Thrombosis Research	2014
24292645	Energetic analysis of the rhodopsin-G-protein complex links the Î±5 helix to GDP release.	Nat Struct Mol Biol	2014
24381287	Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.	Journal of Neuroscience	2014
25037222	A conserved phenylalanine as a relay between the Î±5 helix and the GDP binding region of heterotrimeric Gi protein Î± subunit.	J Biol Chem	2014
25176330	Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.	Bioorganic and Medicinal Chemistry Letters	2014
24568373	Differential localization of G protein Î²Î³ subunits.	Biochemistry	2014
25052834	Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects.	J Pharmacol Exp Ther	2014
23087260	Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.	Molecular Pharmacology	2013