Author details

Full Name

Jonathan K Pritchard

Affiliation

ORCID

Career Start Year

1996

Papers

165

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38093011	Base-editing mutagenesis maps alleles to tune human T cell functions.	Nature	2024
37292653	Bayesian estimation of gene constraint from an evolutionary model with gene features.		2023
37745614	Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease.		2023
37592021	A genetic history of continuity and mobility in the Iron Age central Mediterranean.		2023
37648854	CRISPR screens decode cancer cell pathways that trigger Î³Î´ T cell detection.	Nature	2023
37724741	Scaling the discrete-time Wright-Fisher model to biobank-scale datasets.		2023
37561850	A genome-wide genetic screen uncovers determinants of human pigmentation.	Science	2023
37868038	The functional impact of rare variation across the regulatory cascade.	Cell Genom	2023
37857933	Systematic differences in discovery of genetic effects on gene expression and complex traits.		2023
37410594	On the number of genealogical ancestors tracing to the source groups of an admixed population.		2023
36778251	Diversity of ribosomes at the level of rRNA variation associated with human health and disease.		2023
37024583	Precise modulation of transcription factor levels identifies features underlying dosage sensitivity.		2023
37398424	Bayesian estimation of gene constraint from an evolutionary model with gene features.		2023
37127331	A novel quantitative trait locus implicates <i>Msh3</i> in the propensity for genome-wide short tandem repeat expansions in mice.	Genome Res	2023
37188663	Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.	Nat Commun	2023
37306301	Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs <i>Rps27</i> and <i>Rps27l</i> in vertebrates.	Elife	2023
37293115	Scaling the Discrete-time Wright Fisher model to biobank-scale datasets.		2023
35716666	Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.	Am J Hum Genet	2022
35817986	Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks.	Nat Genet	2022
36073519	Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation.	eLife	2022
35545679	A natural mutator allele shapes mutation spectrum variation in mice.	Nature	2022
35922514	RNA editing underlies genetic risk of common inflammatory diseases.	Nature	2022
34475573	Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.	Nat Genet	2021
33587031	GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background.	Elife	2021
33513366	A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.	Cell Metab	2021
33821002	Shared heritability of human face and brain shape.	Nature Genetics	2021
34608296	Author Correction: Genetics of 35 blood and urine biomarkers in the UK Biobank.	Nat Genet	2021
31974223	Chromatin accessibility dynamics in a model of human forebrain development.	Science	2020
31955845	Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.	Cell	2020
32084344	Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.	Cell	2020
31051098	Trans Effects on Gene Expression Can Drive Omnigenic Inheritance.	Cell	2019
31699931	Ancient Rome: A genetic crossroads of Europe and the Mediterranean.	Science	2019
30554168	Evidence for Weak Selective Constraint on Human Gene Expression.	Genetics	2019
31256875	Public Discussion Affects Question Asking at Academic Conferences.	American Journal of Human Genetics	2019
30895923	Reduced signal for polygenic adaptation of height in UK Biobank.	eLife	2019
30838127	Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences.	Evolution, Medicine and Public Health	2019
29229983	Annotation-free quantification of RNA splicing using LeafCutter.	Nature Genetics	2018
30245013	Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing.	Cell	2018
30573688	High-resolution mapping of cancer cell networks using co-functional interactions.	Mol Syst Biol	2018
29950183	Post-translational buffering leads to convergent protein expression levels between primates.		2018
29625072	Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.	Cell Stem Cell	2018
29478853	Remodeling the Specificity of an Endosomal CORVET Tether Underlies Formation of Regulated Secretory Vesicles in the Ciliate Tetrahymena thermophila.	Current Biology	2018
29208628	Impact of regulatory variation across human iPSCs and differentiated cells.	Genome Res	2018
29737278	Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes.	Elife	2018
28102248	Tracing the peopling of the world through genomics.	Nature	2017
28771616	Quantification of transplant-derived circulating cell-free DNA in absence of a donor genotype.	PLoS Computational Biology	2017
28622505	An Expanded View of Complex Traits: From Polygenic to Omnigenic.	Cell	2017
28440220	Rapid evolution of the human mutation spectrum.	eLife	2017
29138319	Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates.	Proceedings of the National Academy of Sciences of the United States of America	2017
29106824	Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression.	American Journal of Human Genetics	2017