Author details

Full Name

Michael J Holtzman

Affiliation

ORCID

Career Start Year

1979

Papers

230

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37292761	A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.		2023
37942801	Classical Estrogen Signaling in Ciliated Epithelial Cells of the Oviduct Is Nonessential for Fertility in Female Mice.		2023
37847710	A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.		2023
36893755	Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus.	Neuron	2023
37461530	LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus.		2023
37130808	An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease.		2023
36868468	Lung Remodeling Regions in Long-Term Coronavirus Disease 2019 Feature Basal Epithelial Cell Reprogramming.		2023
37349305	Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution.		2023
35110543	Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.	Nature Communications	2022
35523172	Nasally delivered interferon-Î» protects mice against infection by SARS-CoV-2 variants including Omicron.	Cell Rep	2022
36238722	An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease.		2022
36172126	Lung remodeling regions in long-term Covid-19 feature basal epithelial cell reprogramming.		2022
35438004	Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2022
35687143	Secretory Cells Are the Primary Source of pIgR in Small Airways.	American Journal of Respiratory Cell and Molecular Biology	2022
36196585	Dentate gyrus morphogenesis is regulated by Î²-catenin function in hem-derived fimbrial glia.	Development (Cambridge)	2022
34668780	SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice.	J Virol	2022
35173037	Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses.	Journal of Immunology	2022
34880260	Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia.	Nature Communications	2021
33790026	Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.	Sci Transl Med	2021
33469018	Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development.	Nat Commun	2021
33514511	TLR3-Activated Monocyte-Derived Dendritic Cells Trigger Progression from Acute Viral Infection to Chronic Disease in the Lung.	Journal of Immunology	2021
33507882	Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease.	JCI Insight	2021
34137002	Selective Imaging of Lung Macrophages Using [C]PBR28-Based Positron Emission Tomography.	Molecular Imaging and Biology	2021
34343135	Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease.	Journal of Clinical Investigation	2021
34245672	A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters.	Cell Rep	2021
33345425	Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR.	EMBO Reports	2021
32553273	A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.	Cell	2020
32931909	Sex effects in the association between airway microbiome and asthma.	Ann Allergy Asthma Immunol	2020
32931734	A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.	Cell	2020
32879513	Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.	Nat Immunol	2020
32641386	Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease.	Journal of Immunology	2020
33299991	A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters.	bioRxiv	2020
32798445	Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.	Cell Host Microbe	2020
32961128	Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface.	Neuron	2020
32676600	SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function.	bioRxiv	2020
32676597	Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis.	bioRxiv	2020
32668443	Potently neutralizing and protective human antibodies against SARS-CoV-2.	Nature	2020
32839612	SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.	Nat Immunol	2020
32725242	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	Nucleic Acids Research	2020
30804041	Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost.	Journal of Immunology	2019
31748545	Author Correction: The choroid plexus is an important circadian clock component.	Nature Communications	2019
31645418	A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Lung Infection in Mice.	Journal of Immunology	2019
30759005	Epithelial-Immune Cell Interactions for Drug Discovery in Chronic Obstructive Pulmonary Disease.	Annals of the American Thoracic Society	2018
29017955	Triggering Receptor Expressed on Myeloid Cells-2 Expression Tracks With M2-Like Macrophage Activity and Disease Severity inÂ COPD.	Chest	2018
28401936	BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.	Mucosal Immunol	2018
30209189	Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants.	Journal of Immunology	2018
30137026	Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.	J Clin Invest	2018
29481834	Recurrent wheezing in children following human metapneumovirus infection.	J Allergy Clin Immunol	2018
29540683	The choroid plexus is an important circadian clock component.	Nature Communications	2018
28082352	Estrogen receptor Î± is required for oviductal transport of embryos.	FASEB Journal	2017