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Author Details

Vivian Hook
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
1980
188
42
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36970896Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition.J Alzheimers Dis2023
37601062Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.Front Pharmacol2023
37459182Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range.Biochemistry2023
34741130Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia.Mol Psychiatry2022
35710131Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders.Pharmacol Rev2022
35758417Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain.ACS Chem Neurosci2022
35910167Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions.ACS Omega2022
35871359Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease.J Huntingtons Dis2022
35981509Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range.Biochemistry2022
35119840Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B.Biochemistry2022
34986304Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases.ACS Chem Neurosci2022
34730959Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.J Med Chem2022
34056454Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons.ACS Omega2021
33787221A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.ACS Chem Biol2021
34744602Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration.Front Neurosci2021
34416110Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.ACS Chem Biol2021
34153188Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing.ACS Chem Neurosci2021
33981778Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD.Mol Ther Methods Clin Dev2021
32295833Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses.Mol Cell Proteomics2020
33398273Potent <i>in vitro</i> anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L.bioRxiv2020
32899982High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma.Molecules2020
32305689Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.Biochim Biophys Acta Proteins Proteom2020
32330298Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling.J Neurochem2020
30698015Metabolomics Analyses of 14 Classical Neurotransmitters by GC-TOF with LC-MS Illustrates Secretion of 9 Cell-Cell Signaling Molecules from Sympathoadrenal Chromaffin Cells in the Presence of Lithium.ACS Chem Neurosci2019
29956026Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration.J Neurol2019
31355632The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i>.ACS Infect Dis2019
31539239Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and <i>Trypanosoma cruzi</i> Cruzain.J Med Chem2019
30975860The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.Science2019
29556927Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles.J Am Soc Mass Spectrom2018
29998195Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production.Heliyon2018
30008074Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development.J Mol Neurosci2018
30085657A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro.ACS Chem Biol2018
29667161Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry.J Am Soc Mass Spectrom2018
28011710Identification of novel loci affecting circulating chromogranins and related peptides.Hum Mol Genet2017
26738478The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective.Annu Rev Pharmacol Toxicol2016
27732780Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.Anal Chem2016
26092702Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues.Mol Cell Neurosci2015
26388830Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.Front Neurol2015
26483184Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems.J Am Soc Mass Spectrom2015
24266713Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms.J Neurochem2014
25358781Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons.Stem Cell Reports2014
24943989Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Neurodegener Dis2014
24595198Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.J Alzheimers Dis2014
24364476The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L.J Nat Prod2014
24393849Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein.Biochem Biophys Res Commun2014
24083575The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury.J Neurotrauma2014
23290538Spinal astrocytes produce and secrete dynorphin neuropeptides.Neuropeptides2013
23747840Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters.Peptides2013
21925292Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.Biochim Biophys Acta2012
22916103The protein architecture of human secretory vesicles reveals differential regulation of signaling molecule secretion by protein kinases.PLoS One2012
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Collaborators

Anthony J O'Donoghue
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 18
Daniel T O'Connor
Institute for Genomic Medicine, University of California San Diego
Co-authored papers 14
Steven J Bark
University of Houston
Co-authored papers 13
William H Gerwick
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 9
Michael G Ziegler
University of California San Diego School of Medicine
Co-authored papers 9
Jill L Wegrzyn
University of Connecticut
Co-authored papers 9
Sushil K Mahata
Co-authored papers 8
Laurent Taupenot
VA San Diego Healthcare System, University of California at San Diego
Co-authored papers 8
Kuixing Zhang
Co-authored papers 5
Nuno Bandeira
University of California
Co-authored papers 4
Bruce A Hamilton
Co-authored papers 4
Pieter C Dorrestein
Co-authored papers 3
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 3
Caroline M Nievergelt
VA San Diego Healthcare System (VASDHS)
Co-authored papers 3
Ryan S Friese
Co-authored papers 3
Chien-Te K Tseng
The University of Texas Medical Branch
Co-authored papers 3
Laura Beretta
Co-authored papers 3
Gen Wen
Co-authored papers 2
Conor R Caffrey
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 2
Qing Liu
Co-authored papers 2
Shauna H Yuan
Co-authored papers 2
Oliver Fiehn
University of California davis
Co-authored papers 2
Tsuneya Ikezu
Co-authored papers 2
Andrew J Schork
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
Co-authored papers 2
Mark Larance
The University of Sydney
Co-authored papers 2
Tony L Yaksh
University of California
Co-authored papers 2
Vito Turk
Jozef Stefan Institute
Co-authored papers 2
Bradford W Gibson
The Buck Institute for Research on Aging
Co-authored papers 2
Paul A Insel
Co-authored papers 2
Pavel A Pevzner
University of California
Co-authored papers 2
Release 1.2